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Results: 1 to 20 of 166

1.

Structure and mechanistic analysis of the anti-human immunodeficiency virus type 1 antibody 2F5 in complex with its gp41 epitope.

Ofek G, Tang M, Sambor A, Katinger H, Mascola JR, Wyatt R, Kwong PD.

J Virol. 2004 Oct;78(19):10724-37.

PMID:
15367639
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Structural basis for HIV-1 neutralization by 2F5-like antibodies m66 and m66.6.

Ofek G, Zirkle B, Yang Y, Zhu Z, McKee K, Zhang B, Chuang GY, Georgiev IS, O'Dell S, Doria-Rose N, Mascola JR, Dimitrov DS, Kwong PD.

J Virol. 2014 Mar;88(5):2426-41. doi: 10.1128/JVI.02837-13. Epub 2013 Dec 11.

PMID:
24335316
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Interaction of anti-HIV type 1 antibody 2F5 with phospholipid bilayers and its relevance for the mechanism of virus neutralization.

Maeso R, Huarte N, Julien JP, Kunert R, Pai EF, Nieva JL.

AIDS Res Hum Retroviruses. 2011 Aug;27(8):863-76. doi: 10.1089/AID.2010.0265. Epub 2011 Jan 15.

PMID:
21142698
[PubMed - indexed for MEDLINE]
4.

Structural details of HIV-1 recognition by the broadly neutralizing monoclonal antibody 2F5: epitope conformation, antigen-recognition loop mobility, and anion-binding site.

Julien JP, Bryson S, Nieva JL, Pai EF.

J Mol Biol. 2008 Dec 12;384(2):377-92. doi: 10.1016/j.jmb.2008.09.024. Epub 2008 Sep 18.

PMID:
18824005
[PubMed - indexed for MEDLINE]
5.

Anti-human immunodeficiency virus type 1 (HIV-1) antibodies 2F5 and 4E10 require surprisingly few crucial residues in the membrane-proximal external region of glycoprotein gp41 to neutralize HIV-1.

Zwick MB, Jensen R, Church S, Wang M, Stiegler G, Kunert R, Katinger H, Burton DR.

J Virol. 2005 Jan;79(2):1252-61.

PMID:
15613352
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Crystal structure of the complex between the F(ab)' fragment of the cross-neutralizing anti-HIV-1 antibody 2F5 and the F(ab) fragment of its anti-idiotypic antibody 3H6.

Bryson S, Julien JP, Isenman DE, Kunert R, Katinger H, Pai EF.

J Mol Biol. 2008 Oct 17;382(4):910-9. doi: 10.1016/j.jmb.2008.07.057. Epub 2008 Jul 27.

PMID:
18692506
[PubMed - indexed for MEDLINE]
7.

Structure-guided alterations of the gp41-directed HIV-1 broadly neutralizing antibody 2F5 reveal new properties regarding its neutralizing function.

Guenaga J, Wyatt RT.

PLoS Pathog. 2012;8(7):e1002806. doi: 10.1371/journal.ppat.1002806. Epub 2012 Jul 19.

PMID:
22829767
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

The broadly neutralizing anti-human immunodeficiency virus type 1 4E10 monoclonal antibody is better adapted to membrane-bound epitope recognition and blocking than 2F5.

Huarte N, Lorizate M, Maeso R, Kunert R, Arranz R, Valpuesta JM, Nieva JL.

J Virol. 2008 Sep;82(18):8986-96. doi: 10.1128/JVI.00846-08. Epub 2008 Jul 2.

PMID:
18596094
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

The role of antibody polyspecificity and lipid reactivity in binding of broadly neutralizing anti-HIV-1 envelope human monoclonal antibodies 2F5 and 4E10 to glycoprotein 41 membrane proximal envelope epitopes.

Alam SM, McAdams M, Boren D, Rak M, Scearce RM, Gao F, Camacho ZT, Gewirth D, Kelsoe G, Chen P, Haynes BF.

J Immunol. 2007 Apr 1;178(7):4424-35.

PMID:
17372000
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Interactions of HIV-1 antibodies 2F5 and 4E10 with a gp41 epitope prebound to host and viral membrane model systems.

Veiga AS, Pattenden LK, Fletcher JM, Castanho MA, Aguilar MI.

Chembiochem. 2009 Apr 17;10(6):1032-44. doi: 10.1002/cbic.200800609.

PMID:
19283693
[PubMed - indexed for MEDLINE]
11.

An affinity-enhanced neutralizing antibody against the membrane-proximal external region of human immunodeficiency virus type 1 gp41 recognizes an epitope between those of 2F5 and 4E10.

Nelson JD, Brunel FM, Jensen R, Crooks ET, Cardoso RM, Wang M, Hessell A, Wilson IA, Binley JM, Dawson PE, Burton DR, Zwick MB.

J Virol. 2007 Apr;81(8):4033-43. Epub 2007 Feb 7.

PMID:
17287272
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Crystal structure of a non-neutralizing antibody to the HIV-1 gp41 membrane-proximal external region.

Nicely NI, Dennison SM, Spicer L, Scearce RM, Kelsoe G, Ueda Y, Chen H, Liao HX, Alam SM, Haynes BF.

Nat Struct Mol Biol. 2010 Dec;17(12):1492-4. doi: 10.1038/nsmb.1944. Epub 2010 Nov 14.

PMID:
21076400
[PubMed - indexed for MEDLINE]
13.

The long third complementarity-determining region of the heavy chain is important in the activity of the broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2F5.

Zwick MB, Komori HK, Stanfield RL, Church S, Wang M, Parren PW, Kunert R, Katinger H, Wilson IA, Burton DR.

J Virol. 2004 Mar;78(6):3155-61.

PMID:
14990736
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Recognition of membrane-bound fusion-peptide/MPER complexes by the HIV-1 neutralizing 2F5 antibody: implications for anti-2F5 immunogenicity.

Huarte N, Araujo A, Arranz R, Lorizate M, Quendler H, Kunert R, Valpuesta JM, Nieva JL.

PLoS One. 2012;7(12):e52740. doi: 10.1371/journal.pone.0052740. Epub 2012 Dec 21.

PMID:
23285173
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Analysis of the human immunodeficiency virus type 1 gp41 membrane proximal external region arrayed on hepatitis B surface antigen particles.

Phogat S, Svehla K, Tang M, Spadaccini A, Muller J, Mascola J, Berkower I, Wyatt R.

Virology. 2008 Mar 30;373(1):72-84. Epub 2007 Dec 26.

PMID:
18155743
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Crystallographic definition of the epitope promiscuity of the broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2F5: vaccine design implications.

Bryson S, Julien JP, Hynes RC, Pai EF.

J Virol. 2009 Nov;83(22):11862-75. doi: 10.1128/JVI.01604-09. Epub 2009 Sep 9.

PMID:
19740978
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Stable docking of neutralizing human immunodeficiency virus type 1 gp41 membrane-proximal external region monoclonal antibodies 2F5 and 4E10 is dependent on the membrane immersion depth of their epitope regions.

Dennison SM, Stewart SM, Stempel KC, Liao HX, Haynes BF, Alam SM.

J Virol. 2009 Oct;83(19):10211-23. doi: 10.1128/JVI.00571-09. Epub 2009 Jul 29.

PMID:
19640992
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Structure-function analysis of the epitope for 4E10, a broadly neutralizing human immunodeficiency virus type 1 antibody.

Brunel FM, Zwick MB, Cardoso RM, Nelson JD, Wilson IA, Burton DR, Dawson PE.

J Virol. 2006 Feb;80(4):1680-7.

PMID:
16439525
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Broadly neutralizing antibodies targeted to the membrane-proximal external region of human immunodeficiency virus type 1 glycoprotein gp41.

Zwick MB, Labrijn AF, Wang M, Spenlehauer C, Saphire EO, Binley JM, Moore JP, Stiegler G, Katinger H, Burton DR, Parren PW.

J Virol. 2001 Nov;75(22):10892-905.

PMID:
11602729
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Human immunodeficiency virus type 1-neutralizing monoclonal antibody 2F5 is multispecific for sequences flanking the DKW core epitope.

Menendez A, Chow KC, Pan OC, Scott JK.

J Mol Biol. 2004 Apr 23;338(2):311-27.

PMID:
15066434
[PubMed - indexed for MEDLINE]

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