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Results: 1 to 20 of 165

1.

The migrastatin family: discovery of potent cell migration inhibitors by chemical synthesis.

Gaul C, Njardarson JT, Shan D, Dorn DC, Wu KD, Tong WP, Huang XY, Moore MA, Danishefsky SJ.

J Am Chem Soc. 2004 Sep 15;126(36):11326-37.

PMID:
15355116
[PubMed - indexed for MEDLINE]
2.

The total synthesis of (+)-migrastatin.

Gaul C, Njardarson JT, Danishefsky SJ.

J Am Chem Soc. 2003 May 21;125(20):6042-3.

PMID:
12785819
[PubMed - indexed for MEDLINE]
3.

Discovery of potent cell migration inhibitors through total synthesis: lessons from structure-activity studies of (+)-migrastatin.

Njardarson JT, Gaul C, Shan D, Huang XY, Danishefsky SJ.

J Am Chem Soc. 2004 Feb 4;126(4):1038-40.

PMID:
14746469
[PubMed - indexed for MEDLINE]
4.

Synthesis of novel migrastatin and dorrigocin A analogues from D-glucal.

Anquetin G, Rawe SL, McMahon K, Murphy EP, Murphy PV.

Chemistry. 2008;14(5):1592-600.

PMID:
18038383
[PubMed - indexed for MEDLINE]
5.

Lactimidomycin, iso-migrastatin and related glutarimide-containing 12-membered macrolides are extremely potent inhibitors of cell migration.

Ju J, Rajski SR, Lim SK, Seo JW, Peters NR, Hoffmann FM, Shen B.

J Am Chem Soc. 2009 Feb 4;131(4):1370-1. doi: 10.1021/ja808462p.

PMID:
19132897
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Evaluation of new migrastatin and dorrigocin congeners unveils cell migration inhibitors with dramatically improved potency.

Ju J, Rajski SR, Lim SK, Seo JW, Peters NR, Hoffmann FM, Shen B.

Bioorg Med Chem Lett. 2008 Nov 15;18(22):5951-4. doi: 10.1016/j.bmcl.2008.07.072. Epub 2008 Jul 24.

PMID:
18684620
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Migrastatin, a new inhibitor of tumor cell migration from Streptomyces sp. MK929-43F1. Taxonomy, fermentation, isolation and biological activities.

Nakae K, Yoshimoto Y, Sawa T, Homma Y, Hamada M, Takeuchi T, Imoto M.

J Antibiot (Tokyo). 2000 Oct;53(10):1130-6.

PMID:
11132958
[PubMed - indexed for MEDLINE]
Free Article
8.

Concise total synthesis of the potent translation and cell migration inhibitor lactimidomycin.

Micoine K, Fürstner A.

J Am Chem Soc. 2010 Oct 13;132(40):14064-6. doi: 10.1021/ja107141p.

PMID:
20831202
[PubMed - indexed for MEDLINE]
9.

Quantitative structure-activity studies on a series of migrastatin analogs as inhibitors of cancer cell metastasis.

Santos RN, Guido RV, Oliva G, Dias LC, Andricopulo AD.

Med Chem. 2011 May;7(3):155-64. doi: 1573-4064/11 $58.00+.00.

PMID:
21486209
[PubMed - indexed for MEDLINE]
10.

Synthesis of eukaryotic translation elongation inhibitor lactimidomycin via Zn(II)-mediated Horner-Wadsworth-Emmons macrocyclization.

Larsen BJ, Sun Z, Nagorny P.

Org Lett. 2013 Jun 21;15(12):2998-3001. doi: 10.1021/ol401186f. Epub 2013 Jun 3.

PMID:
23731327
[PubMed - indexed for MEDLINE]
11.

Migrastatin analogues inhibit canine mammary cancer cell migration and invasion.

Majchrzak K, Lo Re D, Gajewska M, Bulkowska M, Homa A, Pawłowski K, Motyl T, Murphy PV, Król M.

PLoS One. 2013 Oct 8;8(10):e76789. doi: 10.1371/journal.pone.0076789. eCollection 2013.

PMID:
24116159
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Total syntheses and biological reassessment of lactimidomycin, isomigrastatin and congener glutarimide antibiotics.

Micoine K, Persich P, Llaveria J, Lam MH, Maderna A, Loganzo F, Fürstner A.

Chemistry. 2013 Jun 3;19(23):7370-83. doi: 10.1002/chem.201300393. Epub 2013 Apr 17.

PMID:
23595541
[PubMed - indexed for MEDLINE]
13.

Formal total synthesis of lactimidomycin.

Nagasawa T, Kuwahara S.

Org Lett. 2013 Jun 21;15(12):3002-5. doi: 10.1021/ol401214f. Epub 2013 Jun 3.

PMID:
23731346
[PubMed - indexed for MEDLINE]
14.

Diverted total synthesis leads to the generation of promising cell-migration inhibitors for treatment of tumor metastasis: in vivo and mechanistic studies on the migrastatin core ether analog.

Oskarsson T, Nagorny P, Krauss IJ, Perez L, Mandal M, Yang G, Ouerfelli O, Xiao D, Moore MA, Massagué J, Danishefsky SJ.

J Am Chem Soc. 2010 Mar 10;132(9):3224-8. doi: 10.1021/ja9101503.

PMID:
20155906
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Stereoselective synthesis of E,Z-configured 1,3-dienes by ring-closing metathesis. Application to the total synthesis of lactimidomycin.

Gallenkamp D, Fürstner A.

J Am Chem Soc. 2011 Jun 22;133(24):9232-5. doi: 10.1021/ja2031085. Epub 2011 May 27.

PMID:
21604689
[PubMed - indexed for MEDLINE]
16.

Synthetic analogues of migrastatin that inhibit mammary tumor metastasis in mice.

Shan D, Chen L, Njardarson JT, Gaul C, Ma X, Danishefsky SJ, Huang XY.

Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3772-6. Epub 2005 Feb 22.

PMID:
15728385
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Total syntheses of the actin-binding macrolides latrunculin A, B, C, M, S and 16-epi-latrunculin B.

Fürstner A, De Souza D, Turet L, Fenster MD, Parra-Rapado L, Wirtz C, Mynott R, Lehmann CW.

Chemistry. 2007;13(1):115-34.

PMID:
17091520
[PubMed - indexed for MEDLINE]
18.

Total synthesis of the originally proposed and revised structures of palmerolide A and isomers thereof.

Nicolaou KC, Sun YP, Guduru R, Banerji B, Chen DY.

J Am Chem Soc. 2008 Mar 19;130(11):3633-44. doi: 10.1021/ja710485n. Epub 2008 Feb 26.

PMID:
18298117
[PubMed - indexed for MEDLINE]
19.

Total synthesis and biological evaluation of (+)-neopeltolide and its analogues.

Fuwa H, Saito A, Naito S, Konoki K, Yotsu-Yamashita M, Sasaki M.

Chemistry. 2009 Nov 23;15(46):12807-18. doi: 10.1002/chem.200901675.

PMID:
19882704
[PubMed - indexed for MEDLINE]
20.

Total synthesis of (-)-zampanolide and structure-activity relationship studies on (-)-dactylolide derivatives.

Zurwerra D, Glaus F, Betschart L, Schuster J, Gertsch J, Ganci W, Altmann KH.

Chemistry. 2012 Dec 21;18(52):16868-83. doi: 10.1002/chem.201202553. Epub 2012 Nov 7.

PMID:
23136113
[PubMed - indexed for MEDLINE]
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