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Items: 1 to 20 of 153


The stress kinase MRK contributes to regulation of DNA damage checkpoints through a p38gamma-independent pathway.

Tosti E, Waldbaum L, Warshaw G, Gross EA, Ruggieri R.

J Biol Chem. 2004 Nov 12;279(46):47652-60. Epub 2004 Sep 1.


Differential roles for checkpoint kinases in DNA damage-dependent degradation of the Cdc25A protein phosphatase.

Jin J, Ang XL, Ye X, Livingstone M, Harper JW.

J Biol Chem. 2008 Jul 11;283(28):19322-8. doi: 10.1074/jbc.M802474200. Epub 2008 May 13.


MRK, a mixed lineage kinase-related molecule that plays a role in gamma-radiation-induced cell cycle arrest.

Gross EA, Callow MG, Waldbaum L, Thomas S, Ruggieri R.

J Biol Chem. 2002 Apr 19;277(16):13873-82. Epub 2002 Feb 8.


Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints.

Zhao H, Watkins JL, Piwnica-Worms H.

Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):14795-800. Epub 2002 Oct 24.


Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest.

Wang X, McGowan CH, Zhao M, He L, Downey JS, Fearns C, Wang Y, Huang S, Han J.

Mol Cell Biol. 2000 Jul;20(13):4543-52.


The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis.

Falck J, Mailand N, Syljuåsen RG, Bartek J, Lukas J.

Nature. 2001 Apr 12;410(6830):842-7.


Irradiation-induced G2/M checkpoint response requires ERK1/2 activation.

Yan Y, Black CP, Cowan KH.

Oncogene. 2007 Jul 12;26(32):4689-98. Epub 2007 Feb 5.


DNA damage-induced cell cycle regulation and function of novel Chk2 phosphoresidues.

Buscemi G, Carlessi L, Zannini L, Lisanti S, Fontanella E, Canevari S, Delia D.

Mol Cell Biol. 2006 Nov;26(21):7832-45. Epub 2006 Aug 28.


Dual regulation of Cdc25A by Chk1 and p53-ATF3 in DNA replication checkpoint control.

Demidova AR, Aau MY, Zhuang L, Yu Q.

J Biol Chem. 2009 Feb 13;284(7):4132-9. doi: 10.1074/jbc.M808118200. Epub 2008 Dec 7.


NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint.

Melixetian M, Klein DK, Sørensen CS, Helin K.

Nat Cell Biol. 2009 Oct;11(10):1247-53. doi: 10.1038/ncb1969. Epub 2009 Sep 6.


Arsenic trioxide augments Chk2/p53-mediated apoptosis by inhibiting oncogenic Wip1 phosphatase.

Yoda A, Toyoshima K, Watanabe Y, Onishi N, Hazaka Y, Tsukuda Y, Tsukada J, Kondo T, Tanaka Y, Minami Y.

J Biol Chem. 2008 Jul 4;283(27):18969-79. doi: 10.1074/jbc.M800560200. Epub 2008 May 15.


Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation.

Gatei M, Sloper K, Sorensen C, Syljuäsen R, Falck J, Hobson K, Savage K, Lukas J, Zhou BB, Bartek J, Khanna KK.

J Biol Chem. 2003 Apr 25;278(17):14806-11. Epub 2003 Feb 14.


TTK/hMps1 participates in the regulation of DNA damage checkpoint response by phosphorylating CHK2 on threonine 68.

Wei JH, Chou YF, Ou YH, Yeh YH, Tyan SW, Sun TP, Shen CY, Shieh SY.

J Biol Chem. 2005 Mar 4;280(9):7748-57. Epub 2004 Dec 23.


Priming phosphorylation of Chk2 by polo-like kinase 3 (Plk3) mediates its full activation by ATM and a downstream checkpoint in response to DNA damage.

Bahassi el M, Myer DL, McKenney RJ, Hennigan RF, Stambrook PJ.

Mutat Res. 2006 Apr 11;596(1-2):166-76. Epub 2006 Feb 14.


Linkage of ATM to cell cycle regulation by the Chk2 protein kinase.

Matsuoka S, Huang M, Elledge SJ.

Science. 1998 Dec 4;282(5395):1893-7.


Both ERK1 and ERK2 kinases promote G2/M arrest in etoposide-treated MCF7 cells by facilitating ATM activation.

Wei F, Xie Y, Tao L, Tang D.

Cell Signal. 2010 Nov;22(11):1783-9. doi: 10.1016/j.cellsig.2010.07.007. Epub 2010 Jul 15.


HCLK2 is essential for the mammalian S-phase checkpoint and impacts on Chk1 stability.

Collis SJ, Barber LJ, Clark AJ, Martin JS, Ward JD, Boulton SJ.

Nat Cell Biol. 2007 Apr;9(4):391-401. Epub 2007 Mar 25.

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