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Items: 1 to 20 of 138

1.

Assessing the impact of predictive biosimulation on drug discovery and development.

Michelson S.

J Bioinform Comput Biol. 2003 Apr;1(1):169-77.

PMID:
15290786
2.

The impact of systems biology and biosimulation on drug discovery and development.

Michelson S.

Mol Biosyst. 2006 Jun;2(6-7):288-91. Epub 2006 May 18.

PMID:
16880946
3.

Effective integration of systems biology, biomarkers, biosimulation and modelling in streamlining drug development.

Krishna R, Schaefer HG, Bjerrum OJ.

Eur J Pharm Sci. 2007 May;31(1):62-7. Epub 2007 Feb 20.

PMID:
17408933
4.

Applying computational modeling to drug discovery and development.

Kumar N, Hendriks BS, Janes KA, de Graaf D, Lauffenburger DA.

Drug Discov Today. 2006 Sep;11(17-18):806-11. Review.

PMID:
16935748
5.

Effective integration of systems biology, biomarkers, biosimulation, and modeling in streamlining drug development.

Krishna R, Schaefer HG, Bjerrum OJ.

J Clin Pharmacol. 2007 Jun;47(6):738-43. Epub 2007 Apr 26. No abstract available.

PMID:
17463216
6.

New approaches to drug discovery and development: a mechanism-based approach to pharmaceutical research and its application to BNP7787, a novel chemoprotective agent.

Hausheer FH, Kochat H, Parker AR, Ding D, Yao S, Hamilton SE, Petluru PN, Leverett BD, Bain SH, Saxe JD.

Cancer Chemother Pharmacol. 2003 Jul;52 Suppl 1:S3-15. Epub 2003 Jun 18. Review.

PMID:
12819940
7.

Systems modeling: a pathway to drug discovery.

Rajasethupathy P, Vayttaden SJ, Bhalla US.

Curr Opin Chem Biol. 2005 Aug;9(4):400-6. Review.

PMID:
16006180
8.

Computational systems biology.

Kitano H.

Nature. 2002 Nov 14;420(6912):206-10. Review.

PMID:
12432404
9.

Biosimulation software is changing research.

Ho RL, Bartsell LT.

Biotechnol Annu Rev. 2004;10:297-302. Review.

PMID:
15504712
10.

The impact of systems approaches on biological problems in drug discovery.

Hood L, Perlmutter RM.

Nat Biotechnol. 2004 Oct;22(10):1215-7. No abstract available.

PMID:
15470453
11.

Integrating molecular design resources within modern drug discovery research: the Roche experience.

Stahl M, Guba W, Kansy M.

Drug Discov Today. 2006 Apr;11(7-8):326-33. Review.

PMID:
16580974
12.

Computational systems biology in drug discovery and development: methods and applications.

Materi W, Wishart DS.

Drug Discov Today. 2007 Apr;12(7-8):295-303. Epub 2007 Mar 7. Review.

PMID:
17395089
13.

Recent advances in computational prediction of drug absorption and permeability in drug discovery.

Hou T, Wang J, Zhang W, Wang W, Xu X.

Curr Med Chem. 2006;13(22):2653-67. Review.

PMID:
17017917
15.

Systems biology in drug discovery.

Butcher EC, Berg EL, Kunkel EJ.

Nat Biotechnol. 2004 Oct;22(10):1253-9. Review.

PMID:
15470465
16.

Quantitative proteomics for drug toxicity.

Gao Y, Holland RD, Yu LR.

Brief Funct Genomic Proteomic. 2009 Mar;8(2):158-66. doi: 10.1093/bfgp/elp006. Epub 2009 Apr 7. Review.

17.

The application of systems biology to drug discovery.

Cho CR, Labow M, Reinhardt M, van Oostrum J, Peitsch MC.

Curr Opin Chem Biol. 2006 Aug;10(4):294-302. Epub 2006 Jul 5. Review.

PMID:
16822703
18.

Applications of physiologically based absorption models in drug discovery and development.

Parrott N, Lave T.

Mol Pharm. 2008 Sep-Oct;5(5):760-75. doi: 10.1021/mp8000155. Epub 2008 Jun 12.

PMID:
18547054
19.

In silico prediction of clinical efficacy.

Michelson S, Sehgal A, Friedrich C.

Curr Opin Biotechnol. 2006 Dec;17(6):666-70. Epub 2006 Oct 12. Review.

PMID:
17046236
20.

Computational toxicology: heading toward more relevance in drug discovery and development.

Johnson DE, Rodgers AD.

Curr Opin Drug Discov Devel. 2006 Jan;9(1):29-37. Review.

PMID:
16445115
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