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Results: 1 to 20 of 140

1.

Assessing the impact of predictive biosimulation on drug discovery and development.

Michelson S.

J Bioinform Comput Biol. 2003 Apr;1(1):169-77.

PMID:
15290786
[PubMed - indexed for MEDLINE]
2.

The impact of systems biology and biosimulation on drug discovery and development.

Michelson S.

Mol Biosyst. 2006 Jun;2(6-7):288-91. Epub 2006 May 18.

PMID:
16880946
[PubMed - indexed for MEDLINE]
3.

Effective integration of systems biology, biomarkers, biosimulation and modelling in streamlining drug development.

Krishna R, Schaefer HG, Bjerrum OJ.

Eur J Pharm Sci. 2007 May;31(1):62-7. Epub 2007 Feb 20.

PMID:
17408933
[PubMed - indexed for MEDLINE]
4.

Applying computational modeling to drug discovery and development.

Kumar N, Hendriks BS, Janes KA, de Graaf D, Lauffenburger DA.

Drug Discov Today. 2006 Sep;11(17-18):806-11. Review.

PMID:
16935748
[PubMed - indexed for MEDLINE]
5.

Effective integration of systems biology, biomarkers, biosimulation, and modeling in streamlining drug development.

Krishna R, Schaefer HG, Bjerrum OJ.

J Clin Pharmacol. 2007 Jun;47(6):738-43. Epub 2007 Apr 26. No abstract available.

PMID:
17463216
[PubMed - indexed for MEDLINE]
6.

New approaches to drug discovery and development: a mechanism-based approach to pharmaceutical research and its application to BNP7787, a novel chemoprotective agent.

Hausheer FH, Kochat H, Parker AR, Ding D, Yao S, Hamilton SE, Petluru PN, Leverett BD, Bain SH, Saxe JD.

Cancer Chemother Pharmacol. 2003 Jul;52 Suppl 1:S3-15. Epub 2003 Jun 18. Review.

PMID:
12819940
[PubMed - indexed for MEDLINE]
7.

Systems modeling: a pathway to drug discovery.

Rajasethupathy P, Vayttaden SJ, Bhalla US.

Curr Opin Chem Biol. 2005 Aug;9(4):400-6. Review.

PMID:
16006180
[PubMed - indexed for MEDLINE]
8.

Computational systems biology.

Kitano H.

Nature. 2002 Nov 14;420(6912):206-10. Review.

PMID:
12432404
[PubMed - indexed for MEDLINE]
9.

Biosimulation software is changing research.

Ho RL, Bartsell LT.

Biotechnol Annu Rev. 2004;10:297-302. Review.

PMID:
15504712
[PubMed - indexed for MEDLINE]
10.

The impact of systems approaches on biological problems in drug discovery.

Hood L, Perlmutter RM.

Nat Biotechnol. 2004 Oct;22(10):1215-7. No abstract available.

PMID:
15470453
[PubMed - indexed for MEDLINE]
11.

Integrating molecular design resources within modern drug discovery research: the Roche experience.

Stahl M, Guba W, Kansy M.

Drug Discov Today. 2006 Apr;11(7-8):326-33. Review.

PMID:
16580974
[PubMed - indexed for MEDLINE]
12.

Computational systems biology in drug discovery and development: methods and applications.

Materi W, Wishart DS.

Drug Discov Today. 2007 Apr;12(7-8):295-303. Epub 2007 Mar 7. Review.

PMID:
17395089
[PubMed - indexed for MEDLINE]
13.

Recent advances in computational prediction of drug absorption and permeability in drug discovery.

Hou T, Wang J, Zhang W, Wang W, Xu X.

Curr Med Chem. 2006;13(22):2653-67. Review.

PMID:
17017917
[PubMed - indexed for MEDLINE]
14.
15.

Systems biology in drug discovery.

Butcher EC, Berg EL, Kunkel EJ.

Nat Biotechnol. 2004 Oct;22(10):1253-9. Review.

PMID:
15470465
[PubMed - indexed for MEDLINE]
16.

Quantitative proteomics for drug toxicity.

Gao Y, Holland RD, Yu LR.

Brief Funct Genomic Proteomic. 2009 Mar;8(2):158-66. doi: 10.1093/bfgp/elp006. Epub 2009 Apr 7. Review.

PMID:
19351682
[PubMed - indexed for MEDLINE]
Free Article
17.

The application of systems biology to drug discovery.

Cho CR, Labow M, Reinhardt M, van Oostrum J, Peitsch MC.

Curr Opin Chem Biol. 2006 Aug;10(4):294-302. Epub 2006 Jul 5. Review.

PMID:
16822703
[PubMed - indexed for MEDLINE]
18.

Applications of physiologically based absorption models in drug discovery and development.

Parrott N, Lave T.

Mol Pharm. 2008 Sep-Oct;5(5):760-75. doi: 10.1021/mp8000155. Epub 2008 Jun 12.

PMID:
18547054
[PubMed - indexed for MEDLINE]
19.

In silico prediction of clinical efficacy.

Michelson S, Sehgal A, Friedrich C.

Curr Opin Biotechnol. 2006 Dec;17(6):666-70. Epub 2006 Oct 12. Review.

PMID:
17046236
[PubMed - indexed for MEDLINE]
20.

Computational toxicology: heading toward more relevance in drug discovery and development.

Johnson DE, Rodgers AD.

Curr Opin Drug Discov Devel. 2006 Jan;9(1):29-37. Review.

PMID:
16445115
[PubMed - indexed for MEDLINE]

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