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Structural basis for inhibition of the replication licensing factor Cdt1 by geminin.

Lee C, Hong B, Choi JM, Kim Y, Watanabe S, Ishimi Y, Enomoto T, Tada S, Kim Y, Cho Y.

Nature. 2004 Aug 19;430(7002):913-7. Epub 2004 Aug 1.


Functional domains of the Xenopus replication licensing factor Cdt1.

Ferenbach A, Li A, Brito-Martins M, Blow JJ.

Nucleic Acids Res. 2005 Jan 13;33(1):316-24. Print 2005.


A dimerized coiled-coil domain and an adjoining part of geminin interact with two sites on Cdt1 for replication inhibition.

Saxena S, Yuan P, Dhar SK, Senga T, Takeda D, Robinson H, Kornbluth S, Swaminathan K, Dutta A.

Mol Cell. 2004 Jul 23;15(2):245-58.


A Cdt1-geminin complex licenses chromatin for DNA replication and prevents rereplication during S phase in Xenopus.

Lutzmann M, Maiorano D, Méchali M.

EMBO J. 2006 Dec 13;25(24):5764-74. Epub 2006 Nov 23.


Inhibition of eukaryotic DNA replication by geminin binding to Cdt1.

Wohlschlegel JA, Dwyer BT, Dhar SK, Cvetic C, Walter JC, Dutta A.

Science. 2000 Dec 22;290(5500):2309-12.


Structure and mutagenesis studies of the C-terminal region of licensing factor Cdt1 enable the identification of key residues for binding to replicative helicase Mcm proteins.

Jee J, Mizuno T, Kamada K, Tochio H, Chiba Y, Yanagi K, Yasuda G, Hiroaki H, Hanaoka F, Shirakawa M.

J Biol Chem. 2010 May 21;285(21):15931-40. doi: 10.1074/jbc.M109.075333. Epub 2010 Mar 24.


Mouse geminin inhibits not only Cdt1-MCM6 interactions but also a novel intrinsic Cdt1 DNA binding activity.

Yanagi K, Mizuno T, You Z, Hanaoka F.

J Biol Chem. 2002 Oct 25;277(43):40871-80. Epub 2002 Aug 20.


Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin.

Tada S, Li A, Maiorano D, Méchali M, Blow JJ.

Nat Cell Biol. 2001 Feb;3(2):107-13.


Proteolysis of DNA replication licensing factor Cdt1 in S-phase is performed independently of geminin through its N-terminal region.

Nishitani H, Lygerou Z, Nishimoto T.

J Biol Chem. 2004 Jul 16;279(29):30807-16. Epub 2004 May 11.


Geminin becomes activated as an inhibitor of Cdt1/RLF-B following nuclear import.

Hodgson B, Li A, Tada S, Blow JJ.

Curr Biol. 2002 Apr 16;12(8):678-83.


Inter-origin cooperativity of geminin action establishes an all-or-none switch for replication origin licensing.

Ode KL, Fujimoto K, Kubota Y, Takisawa H.

Genes Cells. 2011 Apr;16(4):380-96. doi: 10.1111/j.1365-2443.2011.01501.x.


MCM9 binds Cdt1 and is required for the assembly of prereplication complexes.

Lutzmann M, Méchali M.

Mol Cell. 2008 Jul 25;31(2):190-200. doi: 10.1016/j.molcel.2008.07.001.


Geminin has dimerization, Cdt1-binding, and destruction domains that are required for biological activity.

Benjamin JM, Torke SJ, Demeler B, McGarry TJ.

J Biol Chem. 2004 Oct 29;279(44):45957-68. Epub 2004 Aug 12.


Cell cycle regulation of the licensing activity of Cdt1 in Xenopus laevis.

Maiorano D, Rul W, Méchali M.

Exp Cell Res. 2004 Apr 15;295(1):138-49.


Quaternary structure of the human Cdt1-Geminin complex regulates DNA replication licensing.

De Marco V, Gillespie PJ, Li A, Karantzelis N, Christodoulou E, Klompmaker R, van Gerwen S, Fish A, Petoukhov MV, Iliou MS, Lygerou Z, Medema RH, Blow JJ, Svergun DI, Taraviras S, Perrakis A.

Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):19807-12. doi: 10.1073/pnas.0905281106. Epub 2009 Nov 11.


Geminin stabilizes Cdt1 during meiosis in Xenopus oocytes.

Narasimhachar Y, Coué M.

J Biol Chem. 2009 Oct 2;284(40):27235-42. doi: 10.1074/jbc.M109.008854. Epub 2009 Aug 5.


Control of DNA replication licensing in a cell cycle.

Nishitani H, Lygerou Z.

Genes Cells. 2002 Jun;7(6):523-34. Review.


Geminin prevents rereplication during xenopus development.

Kerns SL, Torke SJ, Benjamin JM, McGarry TJ.

J Biol Chem. 2007 Feb 23;282(8):5514-21. Epub 2006 Dec 19.

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