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Results: 1 to 20 of 222

1.

A bacterial selection for the directed evolution of pyruvate aldolases.

Griffiths JS, Cheriyan M, Corbell JB, Pocivavsek L, Fierke CA, Toone EJ.

Bioorg Med Chem. 2004 Aug 1;12(15):4067-74.

PMID:
15246084
[PubMed - indexed for MEDLINE]
2.

Directed evolution of a pyruvate aldolase to recognize a long chain acyl substrate.

Cheriyan M, Walters MJ, Kang BD, Anzaldi LL, Toone EJ, Fierke CA.

Bioorg Med Chem. 2011 Nov 1;19(21):6447-53. doi: 10.1016/j.bmc.2011.08.056. Epub 2011 Aug 30.

PMID:
21944547
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Directed evolution of D-2-keto-3-deoxy-6-phosphogluconate aldolase to new variants for the efficient synthesis of D- and L-sugars.

Fong S, Machajewski TD, Mak CC, Wong C.

Chem Biol. 2000 Nov;7(11):873-83.

PMID:
11094340
[PubMed - indexed for MEDLINE]
Free Article
4.

Mechanism of the Class I KDPG aldolase.

Fullerton SW, Griffiths JS, Merkel AB, Cheriyan M, Wymer NJ, Hutchins MJ, Fierke CA, Toone EJ, Naismith JH.

Bioorg Med Chem. 2006 May 1;14(9):3002-10. Epub 2006 Jan 5.

PMID:
16403639
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Improving upon nature: active site remodeling produces highly efficient aldolase activity toward hydrophobic electrophilic substrates.

Cheriyan M, Toone EJ, Fierke CA.

Biochemistry. 2012 Feb 28;51(8):1658-68. doi: 10.1021/bi201899b. Epub 2012 Feb 16.

PMID:
22316217
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

In vivo selection for the directed evolution of L-rhamnulose aldolase from L-rhamnulose-1-phosphate aldolase (RhaD).

Sugiyama M, Hong Z, Greenberg WA, Wong CH.

Bioorg Med Chem. 2007 Sep 1;15(17):5905-11. Epub 2007 Jun 2.

PMID:
17572092
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Cloning, isolation and characterization of the Thermotoga maritima KDPG aldolase.

Griffiths JS, Wymer NJ, Njolito E, Niranjanakumari S, Fierke CA, Toone EJ.

Bioorg Med Chem. 2002 Mar;10(3):545-50.

PMID:
11814840
[PubMed - indexed for MEDLINE]
8.

Structure-based mutagenesis approaches toward expanding the substrate specificity of D-2-deoxyribose-5-phosphate aldolase.

DeSantis G, Liu J, Clark DP, Heine A, Wilson IA, Wong CH.

Bioorg Med Chem. 2003 Jan 2;11(1):43-52.

PMID:
12467706
[PubMed - indexed for MEDLINE]
9.

Comparison of two metal-dependent pyruvate aldolases related by convergent evolution: substrate specificity, kinetic mechanism, and substrate channeling.

Wang W, Baker P, Seah SY.

Biochemistry. 2010 May 4;49(17):3774-82. doi: 10.1021/bi100251u.

PMID:
20364820
[PubMed - indexed for MEDLINE]
10.

Characterization and crystal structure of Escherichia coli KDPGal aldolase.

Walters MJ, Srikannathasan V, McEwan AR, Naismith JH, Fierke CA, Toone EJ.

Bioorg Med Chem. 2008 Jan 15;16(2):710-20. Epub 2007 Oct 18.

PMID:
17981470
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Creation of a shikimate pathway variant.

Ran N, Draths KM, Frost JW.

J Am Chem Soc. 2004 Jun 9;126(22):6856-7.

PMID:
15174841
[PubMed - indexed for MEDLINE]
12.

Directed evolution of 2-keto-3-deoxy-6-phosphogalactonate aldolase to replace 3-deoxy-D-arabino-heptulosonic acid 7-phosphate synthase.

Ran N, Frost JW.

J Am Chem Soc. 2007 May 16;129(19):6130-9. Epub 2007 Apr 24.

PMID:
17451239
[PubMed - indexed for MEDLINE]
13.

A novel screening assay for hydroxynitrile lyases suitable for high-throughput screening.

Krammer B, Rumbold K, Tschemmernegg M, Pöchlauer P, Schwab H.

J Biotechnol. 2007 Mar 30;129(1):151-61. Epub 2006 Oct 14.

PMID:
17157404
[PubMed - indexed for MEDLINE]
14.

Structural and kinetic characterization of 4-hydroxy-4-methyl-2-oxoglutarate/4-carboxy-4-hydroxy-2-oxoadipate aldolase, a protocatechuate degradation enzyme evolutionarily convergent with the HpaI and DmpG pyruvate aldolases.

Wang W, Mazurkewich S, Kimber MS, Seah SY.

J Biol Chem. 2010 Nov 19;285(47):36608-15. doi: 10.1074/jbc.M110.159509. Epub 2010 Sep 15.

PMID:
20843800
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Directed evolution of a new catalytic site in 2-keto-3-deoxy-6-phosphogluconate aldolase from Escherichia coli.

Wymer N, Buchanan LV, Henderson D, Mehta N, Botting CH, Pocivavsek L, Fierke CA, Toone EJ, Naismith JH.

Structure. 2001 Jan 10;9(1):1-9.

PMID:
11342129
[PubMed - indexed for MEDLINE]
Free Article
16.

Pyruvate aldolases in chiral carbon-carbon bond formation.

Walters MJ, Toone EJ.

Nat Protoc. 2007;2(7):1825-30.

PMID:
17641651
[PubMed - indexed for MEDLINE]
17.

Modifying the stereochemistry of an enzyme-catalyzed reaction by directed evolution.

Williams GJ, Domann S, Nelson A, Berry A.

Proc Natl Acad Sci U S A. 2003 Mar 18;100(6):3143-8. Epub 2003 Mar 7.

PMID:
12626743
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Covalent intermediate trapped in 2-keto-3-deoxy-6- phosphogluconate (KDPG) aldolase structure at 1.95-A resolution.

Allard J, Grochulski P, Sygusch J.

Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):3679-84.

PMID:
11274385
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Slow-binding inhibition of 2-keto-3-deoxy-6-phosphogluconate (KDPG) aldolase.

Braga R, Hecquet L, Blonski C.

Bioorg Med Chem. 2004 Jun 1;12(11):2965-72.

PMID:
15142555
[PubMed - indexed for MEDLINE]
20.

Cloning of the two pyruvate kinase isoenzyme structural genes from Escherichia coli: the relative roles of these enzymes in pyruvate biosynthesis.

Ponce E, Flores N, Martinez A, Valle F, Bolívar F.

J Bacteriol. 1995 Oct;177(19):5719-22.

PMID:
7559366
[PubMed - indexed for MEDLINE]
Free PMC Article

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