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Results: 1 to 20 of 214

1.

Expression of the B7.1 costimulatory molecule on pancreatic beta cells abrogates the requirement for CD4 T cells in the development of type 1 diabetes.

Havari E, Lennon-Dumenil AM, Klein L, Neely D, Taylor JA, McInerney MF, Wucherpfennig KW, Lipes MA.

J Immunol. 2004 Jul 15;173(2):787-96.

PMID:
15240665
[PubMed - indexed for MEDLINE]
Free Article
2.

In vivo evidence for the contribution of human histocompatibility leukocyte antigen (HLA)-DQ molecules to the development of diabetes.

Wen L, Wong FS, Tang J, Chen NY, Altieri M, David C, Flavell R, Sherwin R.

J Exp Med. 2000 Jan 3;191(1):97-104.

PMID:
10620608
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Autoimmune diabetes in HLA-DR3/DQ8 transgenic mice expressing the co-stimulatory molecule B7-1 in the beta cells of islets of Langerhans.

Rajagopalan G, Kudva YC, Chen L, Wen L, David CS.

Int Immunol. 2003 Sep;15(9):1035-44.

PMID:
12917255
[PubMed - indexed for MEDLINE]
Free Article
4.

The regulatory role of DR4 in a spontaneous diabetes DQ8 transgenic model.

Wen L, Chen NY, Tang J, Sherwin R, Wong FS.

J Clin Invest. 2001 Apr;107(7):871-80.

PMID:
11285306
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Distinct local immunogenic stimuli dictate differential requirements for CD4+ and CD8+ T cell subsets in the pathogenesis of spontaneous autoimmune diabetes.

Rajagopalan G, Mangalam AK, Sen MM, Kudva YC, David CS.

Autoimmunity. 2007 Nov;40(7):489-96.

PMID:
17966038
[PubMed - indexed for MEDLINE]
6.

Induction of insulitis by glutamic acid decarboxylase peptide-specific and HLA-DQ8-restricted CD4(+) T cells from human DQ transgenic mice.

Wen L, Wong FS, Burkly L, Altieri M, Mamalaki C, Kioussis D, Flavell RA, Sherwin RS.

J Clin Invest. 1998 Sep 1;102(5):947-57. Erratum in: J Clin Invest 1998 Oct 1;102(7):following 1463.

PMID:
9727063
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

The role of lymphocyte subsets in accelerated diabetes in nonobese diabetic-rat insulin promoter-B7-1 (NOD-RIP-B7-1) mice.

Wong FS, Visintin I, Wen L, Granata J, Flavell R, Janeway CA.

J Exp Med. 1998 Jun 15;187(12):1985-93.

PMID:
9625758
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

B7-2 (CD86) controls the priming of autoreactive CD4 T cell response against pancreatic islets.

Yadav D, Judkowski V, Flodstrom-Tullberg M, Sterling L, Redmond WL, Sherman L, Sarvetnick N.

J Immunol. 2004 Sep 15;173(6):3631-9.

PMID:
15356107
[PubMed - indexed for MEDLINE]
Free Article
9.

Modulation of insulitis and type 1 diabetes by transgenic HLA-DR3 and DQ8 in NOD mice lacking endogenous MHC class II.

Kudva YC, Rajagopalan G, Raju R, Abraham RS, Smart M, Hanson J, David CS.

Hum Immunol. 2002 Nov;63(11):987-99.

PMID:
12392851
[PubMed - indexed for MEDLINE]
10.

Expression and function of transgenic HLA-DQ molecules and lymphocyte development in mice lacking invariant chain.

Rajagopalan G, Smart MK, Krco CJ, David CS.

J Immunol. 2002 Aug 15;169(4):1774-83.

PMID:
12165499
[PubMed - indexed for MEDLINE]
Free Article
11.
12.

The influence of the major histocompatibility complex on development of autoimmune diabetes in RIP-B7.1 mice.

Wong FS, Du W, Thomas IJ, Wen L.

Diabetes. 2005 Jul;54(7):2032-40.

PMID:
15983204
[PubMed - indexed for MEDLINE]
Free Article
13.

CD4 T cells play major effector role and CD8 T cells initiating role in spontaneous autoimmune myocarditis of HLA-DQ8 transgenic IAb knockout nonobese diabetic mice.

Hayward SL, Bautista-Lopez N, Suzuki K, Atrazhev A, Dickie P, Elliott JF.

J Immunol. 2006 Jun 15;176(12):7715-25.

PMID:
16751419
[PubMed - indexed for MEDLINE]
Free Article
14.

Human DQ8 can substitute for murine I-Ag7 in the selection of diabetogenic T cells restricted to I-Ag7.

Wen L, Wong FS, Sherwin R, Mora C.

J Immunol. 2002 Apr 1;168(7):3635-40.

PMID:
11907129
[PubMed - indexed for MEDLINE]
Free Article
15.

Coexpression of B7-1 and viral ("self") transgenes in pancreatic beta cells can break peripheral ignorance and lead to spontaneous autoimmune diabetes.

von Herrath MG, Guerder S, Lewicki H, Flavell RA, Oldstone MB.

Immunity. 1995 Dec;3(6):727-38.

PMID:
8777718
[PubMed - indexed for MEDLINE]
16.

Co-expression of HLA DR3 and DQ8 results in the development of spontaneous insulitis and loss of tolerance to GAD65 in transgenic mice.

Abraham RS, Kudva YC, Wilson SB, Strominger JL, David CS.

Diabetes. 2000 Apr;49(4):548-54.

PMID:
10871191
[PubMed - indexed for MEDLINE]
Free Article
17.

Prediction of HLA-DQ8beta cell peptidome using a computational program and its relationship to autoreactive T cells.

Chang KY, Unanue ER.

Int Immunol. 2009 Jun;21(6):705-13. doi: 10.1093/intimm/dxp039. Epub 2009 May 21.

PMID:
19461125
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Costimulator B7-1 confers antigen-presenting-cell function to parenchymal tissue and in conjunction with tumor necrosis factor alpha leads to autoimmunity in transgenic mice.

Guerder S, Picarella DE, Linsley PS, Flavell RA.

Proc Natl Acad Sci U S A. 1994 May 24;91(11):5138-42.

PMID:
7515187
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Preservation of beta-cell function during immune-mediated, B7-1-dependent alpha-cell destruction.

Skak K, Haase C, Michelsen BK.

Eur J Immunol. 2005 Sep;35(9):2583-90.

PMID:
16078275
[PubMed - indexed for MEDLINE]
20.

Beta cell-specific CD80 (B7-1) expression disrupts tissue protection from autoantigen-specific CTL-mediated diabetes.

Pechhold K, Karges W, Blum C, Boehm BO, Harlan DM.

J Autoimmun. 2003 Feb;20(1):1-13.

PMID:
12604308
[PubMed - indexed for MEDLINE]

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