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Items: 1 to 20 of 98


BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice.

Baker DJ, Jeganathan KB, Cameron JD, Thompson M, Juneja S, Kopecka A, Kumar R, Jenkins RB, de Groen PC, Roche P, van Deursen JM.

Nat Genet. 2004 Jul;36(7):744-9. Epub 2004 Jun 20.


Aging-associated vascular phenotype in mutant mice with low levels of BubR1.

Matsumoto T, Baker DJ, d'Uscio LV, Mozammel G, Katusic ZS, van Deursen JM.

Stroke. 2007 Mar;38(3):1050-6. Epub 2007 Feb 1.


Reduced life- and healthspan in mice carrying a mono-allelic BubR1 MVA mutation.

Wijshake T, Malureanu LA, Baker DJ, Jeganathan KB, van de Sluis B, van Deursen JM.

PLoS Genet. 2012;8(12):e1003138. doi: 10.1371/journal.pgen.1003138. Epub 2012 Dec 27.


Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan.

Baker DJ, Dawlaty MM, Wijshake T, Jeganathan KB, Malureanu L, van Ree JH, Crespo-Diaz R, Reyes S, Seaburg L, Shapiro V, Behfar A, Terzic A, van de Sluis B, van Deursen JM.

Nat Cell Biol. 2013 Jan;15(1):96-102. doi: 10.1038/ncb2643. Epub 2012 Dec 16.


Colonic tumorigenesis in BubR1+/-ApcMin/+ compound mutant mice is linked to premature separation of sister chromatids and enhanced genomic instability.

Rao CV, Yang YM, Swamy MV, Liu T, Fang Y, Mahmood R, Jhanwar-Uniyal M, Dai W.

Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4365-70. Epub 2005 Mar 14.


The yin and yang of the Cdkn2a locus in senescence and aging.

Baker DJ, Jin F, van Deursen JM.

Cell Cycle. 2008 Sep 15;7(18):2795-802. Epub 2008 Sep 28.


Loss of BubR1 acetylation causes defects in spindle assembly checkpoint signaling and promotes tumor formation.

Park I, Lee HO, Choi E, Lee YK, Kwon MS, Min J, Park PG, Lee S, Kong YY, Gong G, Lee H.

J Cell Biol. 2013 Jul 22;202(2):295-309. doi: 10.1083/jcb.201210099.


Mutant mice with small amounts of BubR1 display accelerated age-related gliosis.

Hartman TK, Wengenack TM, Poduslo JF, van Deursen JM.

Neurobiol Aging. 2007 Jun;28(6):921-7. Epub 2006 Jun 15.


Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice.

Baker DJ, Jeganathan KB, Malureanu L, Perez-Terzic C, Terzic A, van Deursen JM.

J Cell Biol. 2006 Feb 13;172(4):529-40.


Slippage of mitotic arrest and enhanced tumor development in mice with BubR1 haploinsufficiency.

Dai W, Wang Q, Liu T, Swamy M, Fang Y, Xie S, Mahmood R, Yang YM, Xu M, Rao CV.

Cancer Res. 2004 Jan 15;64(2):440-5.


Impaired Bub1 function in vivo compromises tension-dependent checkpoint function leading to aneuploidy and tumorigenesis.

Schliekelman M, Cowley DO, O'Quinn R, Oliver TG, Lu L, Salmon ED, Van Dyke T.

Cancer Res. 2009 Jan 1;69(1):45-54. doi: 10.1158/0008-5472.CAN-07-6330.


How chromosome mis-segregation leads to cancer: lessons from BubR1 mouse models.

Lee H.

Mol Cells. 2014 Oct 31;37(10):713-8. doi: 10.14348/molcells.2014.0233. Epub 2014 Sep 26. Review.


Mosaic variegated aneuploidy in mouse BubR1 deficient embryos and pregnancy loss in human.

Schmid M, Steinlein C, Tian Q, Hanlon Newell AE, Gessler M, Olson SB, Rosenwald A, Kneitz B, Fedorov LM.

Chromosome Res. 2014 Sep;22(3):375-92. doi: 10.1007/s10577-014-9432-x. Epub 2014 Jul 1. Erratum in: Chromosome Res. 2014 Dec;22(4):645-6.


[Research progress on spindle assembly checkpoint gene BubR1].

Chen ZJ, Li F, Yang J.

Zhejiang Da Xue Xue Bao Yi Xue Ban. 2011 Jul;40(4):446-50. Review. Chinese.


BRCA2 fine-tunes the spindle assembly checkpoint through reinforcement of BubR1 acetylation.

Choi E, Park PG, Lee HO, Lee YK, Kang GH, Lee JW, Han W, Lee HC, Noh DY, Lekomtsev S, Lee H.

Dev Cell. 2012 Feb 14;22(2):295-308. doi: 10.1016/j.devcel.2012.01.009.


Caspase-mediated specific cleavage of BubR1 is a determinant of mitotic progression.

Kim M, Murphy K, Liu F, Parker SE, Dowling ML, Baff W, Kao GD.

Mol Cell Biol. 2005 Nov;25(21):9232-48. Erratum in: Mol Cell Biol. 2007 Mar;27(5):1991.


The many sides of CIN.

Knouse KA, Amon A.

Nat Rev Mol Cell Biol. 2013 Oct;14(10):611. doi: 10.1038/nrm3666. No abstract available.


Transcriptional control of BubR1 by p53 and suppression of centrosome amplification by BubR1.

Oikawa T, Okuda M, Ma Z, Goorha R, Tsujimoto H, Inokuma H, Fukasawa K.

Mol Cell Biol. 2005 May;25(10):4046-61.


The mitotic checkpoint in cancer and aging: what have mice taught us?

Baker DJ, Chen J, van Deursen JM.

Curr Opin Cell Biol. 2005 Dec;17(6):583-9. Epub 2005 Oct 13. Review.

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