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Items: 1 to 20 of 104

1.

Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase.

Cohen HY, Miller C, Bitterman KJ, Wall NR, Hekking B, Kessler B, Howitz KT, Gorospe M, de Cabo R, Sinclair DA.

Science. 2004 Jul 16;305(5682):390-2. Epub 2004 Jun 17.

2.

SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70.

Sundaresan NR, Samant SA, Pillai VB, Rajamohan SB, Gupta MP.

Mol Cell Biol. 2008 Oct;28(20):6384-401. doi: 10.1128/MCB.00426-08. Epub 2008 Aug 18.

3.

SIRT1 promotes DNA repair activity and deacetylation of Ku70.

Jeong J, Juhn K, Lee H, Kim SH, Min BH, Lee KM, Cho MH, Park GH, Lee KH.

Exp Mol Med. 2007 Feb 28;39(1):8-13.

4.

SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction.

Wang F, Nguyen M, Qin FX, Tong Q.

Aging Cell. 2007 Aug;6(4):505-14. Epub 2007 May 23.

5.

Cancer-specific functions of SIRT1 enable human epithelial cancer cell growth and survival.

Ford J, Jiang M, Milner J.

Cancer Res. 2005 Nov 15;65(22):10457-63.

6.

SIRT1 is critical regulator of FOXO-mediated transcription in response to oxidative stress.

Kobayashi Y, Furukawa-Hibi Y, Chen C, Horio Y, Isobe K, Ikeda K, Motoyama N.

Int J Mol Med. 2005 Aug;16(2):237-43.

PMID:
16012755
7.

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan.

Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG, Zipkin RE, Chung P, Kisielewski A, Zhang LL, Scherer B, Sinclair DA.

Nature. 2003 Sep 11;425(6954):191-6. Epub 2003 Aug 24.

PMID:
12939617
8.

The interaction between FOXO and SIRT1: tipping the balance towards survival.

Giannakou ME, Partridge L.

Trends Cell Biol. 2004 Aug;14(8):408-12. Review.

PMID:
15308206
9.

Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase.

Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, Lin Y, Tran H, Ross SE, Mostoslavsky R, Cohen HY, Hu LS, Cheng HL, Jedrychowski MP, Gygi SP, Sinclair DA, Alt FW, Greenberg ME.

Science. 2004 Mar 26;303(5666):2011-5. Epub 2004 Feb 19.

10.

Linking sirtuins, IGF-I signaling, and starvation.

Longo VD.

Exp Gerontol. 2009 Jan-Feb;44(1-2):70-4. doi: 10.1016/j.exger.2008.06.005. Epub 2008 Jun 24. Review.

PMID:
18638538
11.

Long-lived growth hormone receptor knockout mice: interaction of reduced insulin-like growth factor i/insulin signaling and caloric restriction.

Al-Regaiey KA, Masternak MM, Bonkowski M, Sun L, Bartke A.

Endocrinology. 2005 Feb;146(2):851-60. Epub 2004 Oct 21.

PMID:
15498882
12.

Calorie restriction, SIRT1 and metabolism: understanding longevity.

Bordone L, Guarente L.

Nat Rev Mol Cell Biol. 2005 Apr;6(4):298-305. Review.

PMID:
15768047
13.

Research on aging. Gene links calorie deprivation and long life in rodents.

Couzin J.

Science. 2004 Jun 18;304(5678):1731. No abstract available.

PMID:
15205503
14.

SIRT1, neuronal cell survival and the insulin/IGF-1 aging paradox.

Tang BL.

Neurobiol Aging. 2006 Mar;27(3):501-5. Epub 2005 Mar 31. Review.

PMID:
16464659
15.

Mammalian SIRT1 represses forkhead transcription factors.

Motta MC, Divecha N, Lemieux M, Kamel C, Chen D, Gu W, Bultsma Y, McBurney M, Guarente L.

Cell. 2004 Feb 20;116(4):551-63.

16.

Calorie restriction increases life span: a molecular mechanism.

Wolf G.

Nutr Rev. 2006 Feb;64(2 Pt 1):89-92. Review.

PMID:
16536186
17.

SIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stress.

Yang Y, Fu W, Chen J, Olashaw N, Zhang X, Nicosia SV, Bhalla K, Bai W.

Nat Cell Biol. 2007 Nov;9(11):1253-62. Epub 2007 Oct 14. Erratum in: Nat Cell Biol. 2007 Dec;9(12):1442.

18.

Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage.

Wang C, Chen L, Hou X, Li Z, Kabra N, Ma Y, Nemoto S, Finkel T, Gu W, Cress WD, Chen J.

Nat Cell Biol. 2006 Sep;8(9):1025-31. Epub 2006 Aug 6.

PMID:
16892051
19.

Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes.

Milne JC, Lambert PD, Schenk S, Carney DP, Smith JJ, Gagne DJ, Jin L, Boss O, Perni RB, Vu CB, Bemis JE, Xie R, Disch JS, Ng PY, Nunes JJ, Lynch AV, Yang H, Galonek H, Israelian K, Choy W, Iffland A, Lavu S, Medvedik O, Sinclair DA, Olefsky JM, Jirousek MR, Elliott PJ, Westphal CH.

Nature. 2007 Nov 29;450(7170):712-6.

20.

Yeast life-span extension by calorie restriction is independent of NAD fluctuation.

Anderson RM, Latorre-Esteves M, Neves AR, Lavu S, Medvedik O, Taylor C, Howitz KT, Santos H, Sinclair DA.

Science. 2003 Dec 19;302(5653):2124-6. Epub 2003 Nov 6.

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