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Items: 1 to 20 of 93


Primary human immunodeficiency virus type 1 nef alleles show major differences in pathogenicity in transgenic mice.

Priceputu E, Hanna Z, Hu C, Simard MC, Vincent P, Wildum S, Schindler M, Kirchhoff F, Jolicoeur P.

J Virol. 2007 May;81(9):4677-93. Epub 2007 Feb 21.


Normal development and function but impaired memory phenotype of CD8⁺ T cells in transgenic mice expressing HIV-1 Nef in its natural target cells.

Ahmed Rahim MM, Chrobak P, Priceputu E, Hanna Z, Jolicoeur P.

Virology. 2013 Apr 10;438(2):84-97. doi: 10.1016/j.virol.2013.01.008. Epub 2013 Feb 22.


HIV-1 Nef mutations abrogating downregulation of CD4 affect other Nef functions and show reduced pathogenicity in transgenic mice.

Hanna Z, Priceputu E, Hu C, Vincent P, Jolicoeur P.

Virology. 2006 Mar 1;346(1):40-52. Epub 2005 Nov 28.


Expression of simian immunodeficiency virus nef in immune cells of transgenic mice leads to a severe AIDS-like disease.

Simard MC, Chrobak P, Kay DG, Hanna Z, Jothy S, Jolicoeur P.

J Virol. 2002 Apr;76(8):3981-95.


Activation of p21-activated kinase 2 and its association with Nef are conserved in murine cells but are not sufficient to induce an AIDS-like disease in CD4C/HIV transgenic mice.

Vincent P, Priceputu E, Kay D, Saksela K, Jolicoeur P, Hanna Z.

J Biol Chem. 2006 Mar 17;281(11):6940-54. Epub 2005 Dec 28.


Selective expression of human immunodeficiency virus Nef in specific immune cell populations of transgenic mice is associated with distinct AIDS-like phenotypes.

Hanna Z, Priceputu E, Chrobak P, Hu C, Dugas V, Goupil M, Marquis M, de Repentigny L, Jolicoeur P.

J Virol. 2009 Oct;83(19):9743-58. doi: 10.1128/JVI.00125-09. Epub 2009 Jul 15.


The CD4C/HIV(Nef)transgenic model of AIDS.

Jolicoeur P.

Curr HIV Res. 2011 Oct;9(7):524-30.


The AIDS disease of CD4C/HIV transgenic mice shows impaired germinal centers and autoantibodies and develops in the absence of IFN-gamma and IL-6.

Poudrier J, Weng X, Kay DG, Paré G, Calvo EL, Hanna Z, Kosco-Vilbois MH, Jolicoeur P.

Immunity. 2001 Aug;15(2):173-85.


Human endothelial cells enhance human immunodeficiency virus type 1 replication in CD4+ T cells in a Nef-dependent manner in vitro and in vivo.

Choi J, Walker J, Boichuk S, Kirkiles-Smith N, Torpey N, Pober JS, Alexander L.

J Virol. 2005 Jan;79(1):264-76.


Altered CD4+ T cell phenotype and function determine the susceptibility to mucosal candidiasis in transgenic mice expressing HIV-1.

Lewandowski D, Marquis M, Aumont F, Lussier-Morin AC, Raymond M, Sénéchal S, Hanna Z, Jolicoeur P, de Repentigny L.

J Immunol. 2006 Jul 1;177(1):479-91.


HIV- I Nef severely impairs thymocyte development and peripheral T-cell function by a CD4-independent mechanism.

Pennington DJ, Jenkins SA, Brady HJ, Miles CG, Dzierzak EA, Abraham DJ.

Genes Funct. 1997 Dec;1(5-6):321-35.


HIV Nef expression favors the relative preservation of CD4+ T regulatory cells that retain some important suppressive functions.

Chrobak P, Afkhami S, Priceputu E, Poudrier J, Meunier C, Hanna Z, Sparwasser T, Jolicoeur P.

J Immunol. 2014 Feb 15;192(4):1681-92. doi: 10.4049/jimmunol.1203272. Epub 2014 Jan 24.


Activation pathways and human immunodeficiency virus type 1 replication are not altered in CD4+ T cells expressing the nef protein.

Schwartz O, Arenzana-Seisdedos F, Heard JM, Danos O.

AIDS Res Hum Retroviruses. 1992 May;8(5):545-51.


Nef harbors a major determinant of pathogenicity for an AIDS-like disease induced by HIV-1 in transgenic mice.

Hanna Z, Kay DG, Rebai N, Guimond A, Jothy S, Jolicoeur P.

Cell. 1998 Oct 16;95(2):163-75.

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