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Items: 1 to 20 of 104


Critical role for Kit-mediated Src kinase but not PI 3-kinase signaling in pro T and pro B cell development.

Agosti V, Corbacioglu S, Ehlers I, Waskow C, Sommer G, Berrozpe G, Kissel H, Tucker CM, Manova K, Moore MA, Rodewald HR, Besmer P.

J Exp Med. 2004 Mar 15;199(6):867-78.


Point mutation in kit receptor tyrosine kinase reveals essential roles for kit signaling in spermatogenesis and oogenesis without affecting other kit responses.

Kissel H, Timokhina I, Hardy MP, Rothschild G, Tajima Y, Soares V, Angeles M, Whitlow SR, Manova K, Besmer P.

EMBO J. 2000 Mar 15;19(6):1312-26.


A role for kit receptor signaling in Leydig cell steroidogenesis.

Rothschild G, Sottas CM, Kissel H, Agosti V, Manova K, Hardy MP, Besmer P.

Biol Reprod. 2003 Sep;69(3):925-32. Epub 2003 May 28.


Abnormal elevated PTEN expression in the mouse antrum of a model of GIST Kit(K641E/K641E).

Deneubourg L, Ralea S, Gromova P, Parsons R, Vanderwinden JM, Erneux C.

Cell Signal. 2011 Nov;23(11):1857-68. doi: 10.1016/j.cellsig.2011.06.023. Epub 2011 Jul 3.


The D816V mutation of c-Kit circumvents a requirement for Src family kinases in c-Kit signal transduction.

Sun J, Pedersen M, Rönnstrand L.

J Biol Chem. 2009 Apr 24;284(17):11039-47. doi: 10.1074/jbc.M808058200. Epub 2009 Mar 5.


Structure and regulation of Kit protein-tyrosine kinase--the stem cell factor receptor.

Roskoski R Jr.

Biochem Biophys Res Commun. 2005 Dec 23;338(3):1307-15. Epub 2005 Oct 4. Review.


Kit/stem cell factor receptor-induced activation of phosphatidylinositol 3'-kinase is essential for male fertility.

Blume-Jensen P, Jiang G, Hyman R, Lee KF, O'Gorman S, Hunter T.

Nat Genet. 2000 Feb;24(2):157-62.


Critical roles of c-Kit tyrosine residues 567 and 719 in stem cell factor-induced chemotaxis: contribution of src family kinase and PI3-kinase on calcium mobilization and cell migration.

Ueda S, Mizuki M, Ikeda H, Tsujimura T, Matsumura I, Nakano K, Daino H, Honda Zi Z, Sonoyama J, Shibayama H, Sugahara H, Machii T, Kanakura Y.

Blood. 2002 May 1;99(9):3342-9.


Distinct role for c-kit receptor tyrosine kinase and SgIGSF adhesion molecule in attachment of mast cells to fibroblasts.

Koma Y, Ito A, Watabe K, Hirata T, Mizuki M, Yokozaki H, Kitamura T, Kanakura Y, Kitamura Y.

Lab Invest. 2005 Mar;85(3):426-35.


The scaffolding adapter Gab2, via Shp-2, regulates kit-evoked mast cell proliferation by activating the Rac/JNK pathway.

Yu M, Luo J, Yang W, Wang Y, Mizuki M, Kanakura Y, Besmer P, Neel BG, Gu H.

J Biol Chem. 2006 Sep 29;281(39):28615-26. Epub 2006 Jul 27.


Role for the adaptor protein Grb10 in the activation of Akt.

Jahn T, Seipel P, Urschel S, Peschel C, Duyster J.

Mol Cell Biol. 2002 Feb;22(4):979-91.


Phosphatidylinositol 3-kinase and Src family kinases are required for phosphorylation and membrane recruitment of Dok-1 in c-Kit signaling.

Liang X, Wisniewski D, Strife A, Shivakrupa, Clarkson B, Resh MD.

J Biol Chem. 2002 Apr 19;277(16):13732-8. Epub 2002 Feb 1.


Dasatinib (BMS-354825), a dual SRC/ABL kinase inhibitor, inhibits the kinase activity of wild-type, juxtamembrane, and activation loop mutant KIT isoforms associated with human malignancies.

Schittenhelm MM, Shiraga S, Schroeder A, Corbin AS, Griffith D, Lee FY, Bokemeyer C, Deininger MW, Druker BJ, Heinrich MC.

Cancer Res. 2006 Jan 1;66(1):473-81.


Ectopic expression of a c-kitW42 minigene in transgenic mice: recapitulation of W phenotypes and evidence for c-kit function in melanoblast progenitors.

Ray P, Higgins KM, Tan JC, Chu TY, Yee NS, Nguyen H, Lacy E, Besmer P.

Genes Dev. 1991 Dec;5(12A):2265-73.


Gab2 is involved in differential phosphoinositide 3-kinase signaling by two splice forms of c-Kit.

Sun J, Pedersen M, Rönnstrand L.

J Biol Chem. 2008 Oct 10;283(41):27444-51. doi: 10.1074/jbc.M709703200. Epub 2008 Aug 11.

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