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Items: 1 to 20 of 183

1.

Smad4 protein stability is regulated by ubiquitin ligase SCF beta-TrCP1.

Wan M, Tang Y, Tytler EM, Lu C, Jin B, Vickers SM, Yang L, Shi X, Cao X.

J Biol Chem. 2004 Apr 9;279(15):14484-7. Epub 2004 Feb 26.

2.

Acute myelogenous leukemia-derived SMAD4 mutations target the protein to ubiquitin-proteasome degradation.

Yang L, Wang N, Tang Y, Cao X, Wan M.

Hum Mutat. 2006 Sep;27(9):897-905.

PMID:
16865698
3.

Degradation of the tumor suppressor Smad4 by WW and HECT domain ubiquitin ligases.

Morén A, Imamura T, Miyazono K, Heldin CH, Moustakas A.

J Biol Chem. 2005 Jun 10;280(23):22115-23. Epub 2005 Apr 6.

5.

SCF(beta-TrCP1) controls Smad4 protein stability in pancreatic cancer cells.

Wan M, Huang J, Jhala NC, Tytler EM, Yang L, Vickers SM, Tang Y, Lu C, Wang N, Cao X.

Am J Pathol. 2005 May;166(5):1379-92.

6.

CHIP mediates degradation of Smad proteins and potentially regulates Smad-induced transcription.

Li L, Xin H, Xu X, Huang M, Zhang X, Chen Y, Zhang S, Fu XY, Chang Z.

Mol Cell Biol. 2004 Jan;24(2):856-64.

7.

Differential ubiquitination defines the functional status of the tumor suppressor Smad4.

Morén A, Hellman U, Inada Y, Imamura T, Heldin CH, Moustakas A.

J Biol Chem. 2003 Aug 29;278(35):33571-82. Epub 2003 Jun 5.

8.

Sumoylation of Smad4, the common Smad mediator of transforming growth factor-beta family signaling.

Lee PS, Chang C, Liu D, Derynck R.

J Biol Chem. 2003 Jul 25;278(30):27853-63. Epub 2003 May 11.

10.

Loss of Smad4 function in pancreatic tumors: C-terminal truncation leads to decreased stability.

Maurice D, Pierreux CE, Howell M, Wilentz RE, Owen MJ, Hill CS.

J Biol Chem. 2001 Nov 16;276(46):43175-81. Epub 2001 Sep 11.

11.
12.

Ligand-dependent degradation of Smad3 by a ubiquitin ligase complex of ROC1 and associated proteins.

Fukuchi M, Imamura T, Chiba T, Ebisawa T, Kawabata M, Tanaka K, Miyazono K.

Mol Biol Cell. 2001 May;12(5):1431-43.

13.

Differential regulation of TGF-beta signaling through Smad2, Smad3 and Smad4.

Kretschmer A, Moepert K, Dames S, Sternberger M, Kaufmann J, Klippel A.

Oncogene. 2003 Oct 2;22(43):6748-63.

PMID:
14555988
14.
15.

Pin1 down-regulates transforming growth factor-beta (TGF-beta) signaling by inducing degradation of Smad proteins.

Nakano A, Koinuma D, Miyazawa K, Uchida T, Saitoh M, Kawabata M, Hanai J, Akiyama H, Abe M, Miyazono K, Matsumoto T, Imamura T.

J Biol Chem. 2009 Mar 6;284(10):6109-15. doi: 10.1074/jbc.M804659200. Epub 2009 Jan 4.

17.

M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP.

Watanabe N, Arai H, Nishihara Y, Taniguchi M, Watanabe N, Hunter T, Osada H.

Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4419-24. Epub 2004 Mar 22.

18.

CHIP controls the sensitivity of transforming growth factor-beta signaling by modulating the basal level of Smad3 through ubiquitin-mediated degradation.

Xin H, Xu X, Li L, Ning H, Rong Y, Shang Y, Wang Y, Fu XY, Chang Z.

J Biol Chem. 2005 May 27;280(21):20842-50. Epub 2005 Mar 21.

19.

Activation of transforming growth factor-beta signaling by SUMO-1 modification of tumor suppressor Smad4/DPC4.

Lin X, Liang M, Liang YY, Brunicardi FC, Melchior F, Feng XH.

J Biol Chem. 2003 May 23;278(21):18714-9. Epub 2003 Mar 5.

20.

Molecular and functional consequences of Smad4 C-terminal missense mutations in colorectal tumour cells.

De Bosscher K, Hill CS, Nicolás FJ.

Biochem J. 2004 Apr 1;379(Pt 1):209-16.

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