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Results: 1 to 20 of 169

1.

Tissue damage in the amyloidoses: Transthyretin monomers and nonnative oligomers are the major cytotoxic species in tissue culture.

Reixach N, Deechongkit S, Jiang X, Kelly JW, Buxbaum JN.

Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2817-22. Epub 2004 Feb 23.

PMID:
14981241
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Prefibrillar transthyretin oligomers and cold stored native tetrameric transthyretin are cytotoxic in cell culture.

Sörgjerd K, Klingstedt T, Lindgren M, Kågedal K, Hammarström P.

Biochem Biophys Res Commun. 2008 Dec 26;377(4):1072-8. doi: 10.1016/j.bbrc.2008.10.121. Epub 2008 Nov 5.

PMID:
18983977
[PubMed - indexed for MEDLINE]
3.

Comparison of lethal and nonlethal transthyretin variants and their relationship to amyloid disease.

McCutchen SL, Lai Z, Miroy GJ, Kelly JW, Colón W.

Biochemistry. 1995 Oct 17;34(41):13527-36.

PMID:
7577941
[PubMed - indexed for MEDLINE]
4.

Retention of misfolded mutant transthyretin by the chaperone BiP/GRP78 mitigates amyloidogenesis.

Sörgjerd K, Ghafouri B, Jonsson BH, Kelly JW, Blond SY, Hammarström P.

J Mol Biol. 2006 Feb 17;356(2):469-82. Epub 2005 Dec 5.

PMID:
16376939
[PubMed - indexed for MEDLINE]
5.

Transthyretin aggregation under partially denaturing conditions is a downhill polymerization.

Hurshman AR, White JT, Powers ET, Kelly JW.

Biochemistry. 2004 Jun 15;43(23):7365-81.

PMID:
15182180
[PubMed - indexed for MEDLINE]
6.

Native state stabilization by NSAIDs inhibits transthyretin amyloidogenesis from the most common familial disease variants.

Miller SR, Sekijima Y, Kelly JW.

Lab Invest. 2004 May;84(5):545-52.

PMID:
14968122
[PubMed - indexed for MEDLINE]
Free Article
7.

Serum transthyretin monomer in patients with familial amyloid polyneuropathy.

Sekijima Y, Tokuda T, Kametani F, Tanaka K, Maruyama K, Ikeda S.

Amyloid. 2001 Dec;8(4):257-62.

PMID:
11791618
[PubMed - indexed for MEDLINE]
8.

Transthyretin amyloidosis: a tale of weak interactions.

Saraiva MJ.

FEBS Lett. 2001 Jun 8;498(2-3):201-3. Review.

PMID:
11412857
[PubMed - indexed for MEDLINE]
Free Article
9.
10.

Transthyretin fibrillogenesis entails the assembly of monomers: a molecular model for in vitro assembled transthyretin amyloid-like fibrils.

Cardoso I, Goldsbury CS, Müller SA, Olivieri V, Wirtz S, Damas AM, Aebi U, Saraiva MJ.

J Mol Biol. 2002 Apr 12;317(5):683-95.

PMID:
11955017
[PubMed - indexed for MEDLINE]
11.

Enhanced transthyretin tetramer stability following expression of an amyloid disease transsuppressor variant in mammalian cells.

Kamata M, Susanto MT, Chen IS.

J Gene Med. 2009 Feb;11(2):103-11. doi: 10.1002/jgm.1276.

PMID:
19065606
[PubMed - indexed for MEDLINE]
12.

D18G transthyretin is monomeric, aggregation prone, and not detectable in plasma and cerebrospinal fluid: a prescription for central nervous system amyloidosis?

Hammarström P, Sekijima Y, White JT, Wiseman RL, Lim A, Costello CE, Altland K, Garzuly F, Budka H, Kelly JW.

Biochemistry. 2003 Jun 10;42(22):6656-63.

PMID:
12779320
[PubMed - indexed for MEDLINE]
13.

Kinetic stabilization of the native state by protein engineering: implications for inhibition of transthyretin amyloidogenesis.

Foss TR, Kelker MS, Wiseman RL, Wilson IA, Kelly JW.

J Mol Biol. 2005 Apr 8;347(4):841-54.

PMID:
15769474
[PubMed - indexed for MEDLINE]
14.

Formation of cytotoxic transthyretin is not dependent on inter-molecular disulphide bridges commonly found within the amyloid form.

Lindhagen-Persson M, Vestling M, Reixach N, Olofsson A.

Amyloid. 2008 Dec;15(4):240-5. doi: 10.1080/13506120802524916.

PMID:
19065295
[PubMed - indexed for MEDLINE]
15.

R104H may suppress transthyretin amyloidogenesis by thermodynamic stabilization, but not by the kinetic mechanism characterizing T119 interallelic trans-suppression.

Sekijima Y, Dendle MT, Wiseman RL, White JT, D'Haeze W, Kelly JW.

Amyloid. 2006 Jun;13(2):57-66.

PMID:
16911959
[PubMed - indexed for MEDLINE]
16.

Transthyretin quaternary and tertiary structural changes facilitate misassembly into amyloid.

Kelly JW, Colon W, Lai Z, Lashuel HA, McCulloch J, McCutchen SL, Miroy GJ, Peterson SA.

Adv Protein Chem. 1997;50:161-81. Review.

PMID:
9338081
[PubMed - indexed for MEDLINE]
18.

Native state kinetic stabilization as a strategy to ameliorate protein misfolding diseases: a focus on the transthyretin amyloidoses.

Johnson SM, Wiseman RL, Sekijima Y, Green NS, Adamski-Werner SL, Kelly JW.

Acc Chem Res. 2005 Dec;38(12):911-21. Review.

PMID:
16359163
[PubMed - indexed for MEDLINE]
19.

Transthyretin forms amyloid fibrils at physiological pH with ultrasonication.

Misumi Y, Ueda M, Fujimori H, Shinriki S, Meng W, Kim J, Saito S, Obayashi K, Uchino M, Ando Y.

Amyloid. 2008 Dec;15(4):234-9. doi: 10.1080/13506120802524684.

PMID:
19065294
[PubMed - indexed for MEDLINE]
20.

The amyloidogenic potential of transthyretin variants correlates with their tendency to aggregate in solution.

Quintas A, Saraiva MJ, Brito RM.

FEBS Lett. 1997 Dec 1;418(3):297-300.

PMID:
9428731
[PubMed - indexed for MEDLINE]
Free Article

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