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Items: 1 to 20 of 190


The low-density lipoprotein receptor: ligands, debates and lore.

Rudenko G, Deisenhofer J.

Curr Opin Struct Biol. 2003 Dec;13(6):683-9. Review.


The complex of the insect LDL receptor homolog, lipophorin receptor, LpR, and its lipoprotein ligand does not dissociate under endosomal conditions.

Roosendaal SD, Kerver J, Schipper M, Rodenburg KW, Van der Horst DJ.

FEBS J. 2008 Apr;275(8):1751-66. doi: 10.1111/j.1742-4658.2008.06334.x. Epub 2008 Mar 7.


Structure of the LDL receptor extracellular domain at endosomal pH.

Rudenko G, Henry L, Henderson K, Ichtchenko K, Brown MS, Goldstein JL, Deisenhofer J.

Science. 2002 Dec 20;298(5602):2353-8. Epub 2002 Nov 29.


Mechanism of low density lipoprotein (LDL) release in the endosome: implications of the stability and Ca2+ affinity of the fifth binding module of the LDL receptor.

Arias-Moreno X, Velazquez-Campoy A, RodrĂ­guez JC, PocovĂ­ M, Sancho J.

J Biol Chem. 2008 Aug 15;283(33):22670-9. doi: 10.1074/jbc.M802153200. Epub 2008 Jun 23.


NMR structure and backbone dynamics of a concatemer of epidermal growth factor homology modules of the human low-density lipoprotein receptor.

Kurniawan ND, Aliabadizadeh K, Brereton IM, Kroon PA, Smith R.

J Mol Biol. 2001 Aug 10;311(2):341-56.


The first epidermal growth factor-like domain of the low-density lipoprotein receptor contains a noncanonical calcium binding site.

Malby S, Pickering R, Saha S, Smallridge R, Linse S, Downing AK.

Biochemistry. 2001 Feb 27;40(8):2555-63.


Cooperation between fixed and low pH-inducible interfaces controls lipoprotein release by the LDL receptor.

Beglova N, Jeon H, Fisher C, Blacklow SC.

Mol Cell. 2004 Oct 22;16(2):281-92.


Functional domains of the very low density lipoprotein receptor: molecular analysis of ligand binding and acid-dependent ligand dissociation mechanisms.

Mikhailenko I, Considine W, Argraves KM, Loukinov D, Hyman BT, Strickland DK.

J Cell Sci. 1999 Oct;112 ( Pt 19):3269-81.


Structural features of the low-density lipoprotein receptor facilitating ligand binding and release.

Beglova N, Jeon H, Fisher C, Blacklow SC.

Biochem Soc Trans. 2004 Nov;32(Pt 5):721-3. Review.


Crystal structure of human lectin-like, oxidized low-density lipoprotein receptor 1 ligand binding domain and its ligand recognition mode to OxLDL.

Ohki I, Ishigaki T, Oyama T, Matsunaga S, Xie Q, Ohnishi-Kameyama M, Murata T, Tsuchiya D, Machida S, Morikawa K, Tate S.

Structure. 2005 Jun;13(6):905-17.


Insect lipoprotein follows a transferrin-like recycling pathway that is mediated by the insect LDL receptor homologue.

Van Hoof D, Rodenburg KW, Van der Horst DJ.

J Cell Sci. 2002 Nov 1;115(Pt 21):4001-12.


Structural biology. LDL receptor's beta-propeller displaces LDL.

Innerarity TL.

Science. 2002 Dec 20;298(5602):2337-9. No abstract available.


The LDL receptor: how acid pulls the trigger.

Beglova N, Blacklow SC.

Trends Biochem Sci. 2005 Jun;30(6):309-17. Review.


Mathematical modelling of competitive LDL/VLDL binding and uptake by hepatocytes.

Pearson T, Wattis JA, O'Malley B, Pickersgill L, Blackburn H, Jackson KG, Byrne HM.

J Math Biol. 2009 Jun;58(6):845-80. doi: 10.1007/s00285-008-0205-z. Epub 2008 Aug 14.


Endocytosis of apolipoprotein A-V by members of the low density lipoprotein receptor and the VPS10p domain receptor families.

Nilsson SK, Christensen S, Raarup MK, Ryan RO, Nielsen MS, Olivecrona G.

J Biol Chem. 2008 Sep 19;283(38):25920-7. doi: 10.1074/jbc.M802721200. Epub 2008 Jul 3.


Identification and characterization of the acidic pH binding sites for growth regulatory ligands of low density lipoprotein receptor-related protein-1.

Ling TY, Chen CL, Huang YH, Liu IH, Huang SS, Huang JS.

J Biol Chem. 2004 Sep 10;279(37):38736-48. Epub 2004 Jun 28.


Mechanism of LDL binding and release probed by structure-based mutagenesis of the LDL receptor.

Huang S, Henry L, Ho YK, Pownall HJ, Rudenko G.

J Lipid Res. 2010 Feb;51(2):297-308. doi: 10.1194/jlr.M000422. Epub 2009 Aug 11.

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