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Items: 1 to 20 of 149


The regulated association of Cdt1 with minichromosome maintenance proteins and Cdc6 in mammalian cells.

Cook JG, Chasse DA, Nevins JR.

J Biol Chem. 2004 Mar 5;279(10):9625-33. Epub 2003 Dec 11.


Mouse geminin inhibits not only Cdt1-MCM6 interactions but also a novel intrinsic Cdt1 DNA binding activity.

Yanagi K, Mizuno T, You Z, Hanaoka F.

J Biol Chem. 2002 Oct 25;277(43):40871-80. Epub 2002 Aug 20.


Analysis of Cdc6 function in the assembly of mammalian prereplication complexes.

Cook JG, Park CH, Burke TW, Leone G, DeGregori J, Engel A, Nevins JR.

Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1347-52. Epub 2002 Jan 22.


Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding.

Sugimoto N, Tatsumi Y, Tsurumi T, Matsukage A, Kiyono T, Nishitani H, Fujita M.

J Biol Chem. 2004 May 7;279(19):19691-7. Epub 2004 Mar 1.


Identification of Tah11/Sid2 as the ortholog of the replication licensing factor Cdt1 in Saccharomyces cerevisiae.

Devault A, Vallen EA, Yuan T, Green S, Bensimon A, Schwob E.

Curr Biol. 2002 Apr 16;12(8):689-94.


Proteolysis of DNA replication licensing factor Cdt1 in S-phase is performed independently of geminin through its N-terminal region.

Nishitani H, Lygerou Z, Nishimoto T.

J Biol Chem. 2004 Jul 16;279(29):30807-16. Epub 2004 May 11.


The essential role of Saccharomyces cerevisiae CDC6 nucleotide-binding site in cell growth, DNA synthesis, and Orc1 association.

Wang B, Feng L, Hu Y, Huang SH, Reynolds CP, Wu L, Jong AY.

J Biol Chem. 1999 Mar 19;274(12):8291-8.


Structure and mutagenesis studies of the C-terminal region of licensing factor Cdt1 enable the identification of key residues for binding to replicative helicase Mcm proteins.

Jee J, Mizuno T, Kamada K, Tochio H, Chiba Y, Yanagi K, Yasuda G, Hiroaki H, Hanaoka F, Shirakawa M.

J Biol Chem. 2010 May 21;285(21):15931-40. doi: 10.1074/jbc.M109.075333. Epub 2010 Mar 24.


The roles of the MCM, ORC, and Cdc6 proteins in determining the replication competence of chromatin in quiescent cells.

Madine MA, Swietlik M, Pelizon C, Romanowski P, Mills AD, Laskey RA.

J Struct Biol. 2000 Apr;129(2-3):198-210.


Cdt1 and geminin are down-regulated upon cell cycle exit and are over-expressed in cancer-derived cell lines.

Xouri G, Lygerou Z, Nishitani H, Pachnis V, Nurse P, Taraviras S.

Eur J Biochem. 2004 Aug;271(16):3368-78.


An ORC/Cdc6/MCM2-7 complex is formed in a multistep reaction to serve as a platform for MCM double-hexamer assembly.

Fernández-Cid A, Riera A, Tognetti S, Herrera MC, Samel S, Evrin C, Winkler C, Gardenal E, Uhle S, Speck C.

Mol Cell. 2013 May 23;50(4):577-88. doi: 10.1016/j.molcel.2013.03.026. Epub 2013 Apr 18.


Multiple Cdt1 molecules act at each origin to load replication-competent Mcm2-7 helicases.

Takara TJ, Bell SP.

EMBO J. 2011 Nov 1;30(24):4885-96. doi: 10.1038/emboj.2011.394.


DNA replication licensing in somatic and germ cells.

Eward KL, Obermann EC, Shreeram S, Loddo M, Fanshawe T, Williams C, Jung HI, Prevost AT, Blow JJ, Stoeber K, Williams GH.

J Cell Sci. 2004 Nov 15;117(Pt 24):5875-86. Epub 2004 Nov 2.


Recruitment of Xenopus Scc2 and cohesin to chromatin requires the pre-replication complex.

Takahashi TS, Yiu P, Chou MF, Gygi S, Walter JC.

Nat Cell Biol. 2004 Oct;6(10):991-6. Epub 2004 Sep 26.


The Xenopus Xmus101 protein is required for the recruitment of Cdc45 to origins of DNA replication.

Van Hatten RA, Tutter AV, Holway AH, Khederian AM, Walter JC, Michael WM.

J Cell Biol. 2002 Nov 25;159(4):541-7. Epub 2002 Nov 18.


Licensing for DNA replication requires a strict sequential assembly of Cdc6 and Cdt1 onto chromatin in Xenopus egg extracts.

Tsuyama T, Tada S, Watanabe S, Seki M, Enomoto T.

Nucleic Acids Res. 2005 Feb 1;33(2):765-75. Print 2005.


Xenopus Cdc6 performs separate functions in initiating DNA replication.

Frolova NS, Schek N, Tikhmyanova N, Coleman TR.

Mol Biol Cell. 2002 Apr;13(4):1298-312.

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