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SIAH-1 interacts with CtIP and promotes its degradation by the proteasome pathway.

Germani A, Prabel A, Mourah S, Podgorniak MP, Di Carlo A, Ehrlich R, Gisselbrecht S, Varin-Blank N, Calvo F, Bruzzoni-Giovanelli H.

Oncogene. 2003 Dec 4;22(55):8845-51.


SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis.

Germani A, Bruzzoni-Giovanelli H, Fellous A, Gisselbrecht S, Varin-Blank N, Calvo F.

Oncogene. 2000 Dec 7;19(52):5997-6006.


p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG-1.

Matsuzawa S, Takayama S, Froesch BA, Zapata JM, Reed JC.

EMBO J. 1998 May 15;17(10):2736-47.


Siah-1 facilitates ubiquitination and degradation of synphilin-1.

Nagano Y, Yamashita H, Takahashi T, Kishida S, Nakamura T, Iseki E, Hattori N, Mizuno Y, Kikuchi A, Matsumoto M.

J Biol Chem. 2003 Dec 19;278(51):51504-14. Epub 2003 Sep 23.


The coiled-coil domain is the structural determinant for mammalian homologues of Drosophila Sina-mediated degradation of promyelocytic leukemia protein and other tripartite motif proteins by the proteasome.

Fanelli M, Fantozzi A, De Luca P, Caprodossi S, Matsuzawa S, Lazar MA, Pelicci PG, Minucci S.

J Biol Chem. 2004 Feb 13;279(7):5374-9. Epub 2003 Nov 25.


The ubiquitin ligase COP1 is a critical negative regulator of p53.

Dornan D, Wertz I, Shimizu H, Arnott D, Frantz GD, Dowd P, O'Rourke K, Koeppen H, Dixit VM.

Nature. 2004 May 6;429(6987):86-92. Epub 2004 Apr 21.


SIAH-1 interacts with mammalian polyhomeotic homologues HPH2 and affects its stability via the ubiquitin-proteasome pathway.

Wu H, Lin Y, Shi Y, Qian W, Tian Z, Yu Y, Huo K.

Biochem Biophys Res Commun. 2010 Jul 2;397(3):391-6. doi: 10.1016/j.bbrc.2010.05.024. Epub 2010 May 22.


SIAH-1 promotes apoptosis and tumor suppression through a network involving the regulation of protein folding, unfolding, and trafficking: identification of common effectors with p53 and p21(Waf1).

Roperch JP, Lethrone F, Prieur S, Piouffre L, Israeli D, Tuynder M, Nemani M, Pasturaud P, Gendron MC, Dausset J, Oren M, Amson RB, Telerman A.

Proc Natl Acad Sci U S A. 1999 Jul 6;96(14):8070-3.


MDM2 is a negative regulator of p21WAF1/CIP1, independent of p53.

Zhang Z, Wang H, Li M, Agrawal S, Chen X, Zhang R.

J Biol Chem. 2004 Apr 16;279(16):16000-6. Epub 2004 Feb 3.


Interferon-inducible Myc/STAT-interacting protein Nmi associates with IFP 35 into a high molecular mass complex and inhibits proteasome-mediated degradation of IFP 35.

Chen J, Shpall RL, Meyerdierks A, Hagemeier M, Böttger EC, Naumovski L.

J Biol Chem. 2000 Nov 17;275(46):36278-84.


Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53.

Rajendra R, Malegaonkar D, Pungaliya P, Marshall H, Rasheed Z, Brownell J, Liu LF, Lutzker S, Saleem A, Rubin EH.

J Biol Chem. 2004 Aug 27;279(35):36440-4. Epub 2004 Jul 9.


BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIP.

Yu X, Fu S, Lai M, Baer R, Chen J.

Genes Dev. 2006 Jul 1;20(13):1721-6.


Knocking down PML impairs p53 signaling transduction pathway and suppresses irradiation induced apoptosis in breast carcinoma cell MCF-7.

Bao-Lei T, Zhu-Zhong M, Yi S, Jun-Jie Q, Yan D, Hua L, Bin L, Guo-Wei Z, Zhi-Xian S.

J Cell Biochem. 2006 Feb 15;97(3):561-71.


Binding of CtIP to the BRCT repeats of BRCA1 involved in the transcription regulation of p21 is disrupted upon DNA damage.

Li S, Chen PL, Subramanian T, Chinnadurai G, Tomlinson G, Osborne CK, Sharp ZD, Lee WH.

J Biol Chem. 1999 Apr 16;274(16):11334-8.


The F-box protein Skp2 participates in c-Myc proteosomal degradation and acts as a cofactor for c-Myc-regulated transcription.

von der Lehr N, Johansson S, Wu S, Bahram F, Castell A, Cetinkaya C, Hydbring P, Weidung I, Nakayama K, Nakayama KI, Söderberg O, Kerppola TK, Larsson LG.

Mol Cell. 2003 May;11(5):1189-200.


Regulation of synaptophysin degradation by mammalian homologues of seven in absentia.

Wheeler TC, Chin LS, Li Y, Roudabush FL, Li L.

J Biol Chem. 2002 Mar 22;277(12):10273-82. Epub 2002 Jan 10.

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