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Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage.

Busino L, Donzelli M, Chiesa M, Guardavaccaro D, Ganoth D, Dorrello NV, Hershko A, Pagano M, Draetta GF.

Nature. 2003 Nov 6;426(6962):87-91.


Differential roles for checkpoint kinases in DNA damage-dependent degradation of the Cdc25A protein phosphatase.

Jin J, Ang XL, Ye X, Livingstone M, Harper JW.

J Biol Chem. 2008 Jul 11;283(28):19322-8. doi: 10.1074/jbc.M802474200. Epub 2008 May 13.


SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase.

Jin J, Shirogane T, Xu L, Nalepa G, Qin J, Elledge SJ, Harper JW.

Genes Dev. 2003 Dec 15;17(24):3062-74. Epub 2003 Dec 17.


Beta-TrCP recognizes a previously undescribed nonphosphorylated destruction motif in Cdc25A and Cdc25B phosphatases.

Kanemori Y, Uto K, Sagata N.

Proc Natl Acad Sci U S A. 2005 May 3;102(18):6279-84. Epub 2005 Apr 21.


The extracellular signal-regulated kinase-mitogen-activated protein kinase pathway phosphorylates and targets Cdc25A for SCF beta-TrCP-dependent degradation for cell cycle arrest.

Isoda M, Kanemori Y, Nakajo N, Uchida S, Yamashita K, Ueno H, Sagata N.

Mol Biol Cell. 2009 Apr;20(8):2186-95. doi: 10.1091/mbc.E09-01-0008. Epub 2009 Feb 25.


NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint.

Melixetian M, Klein DK, Sørensen CS, Helin K.

Nat Cell Biol. 2009 Oct;11(10):1247-53. doi: 10.1038/ncb1969. Epub 2009 Sep 6.


Transforming growth factor beta facilitates beta-TrCP-mediated degradation of Cdc25A in a Smad3-dependent manner.

Ray D, Terao Y, Nimbalkar D, Chu LH, Donzelli M, Tsutsui T, Zou X, Ghosh AK, Varga J, Draetta GF, Kiyokawa H.

Mol Cell Biol. 2005 Apr;25(8):3338-47.


Hierarchical order of phosphorylation events commits Cdc25A to betaTrCP-dependent degradation.

Donzelli M, Busino L, Chiesa M, Ganoth D, Hershko A, Draetta GF.

Cell Cycle. 2004 Apr;3(4):469-71. Epub 2004 Apr 1.


Cdc25A phosphatase: combinatorial phosphorylation, ubiquitylation and proteolysis.

Busino L, Chiesa M, Draetta GF, Donzelli M.

Oncogene. 2004 Mar 15;23(11):2050-6. Review.


The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis.

Falck J, Mailand N, Syljuåsen RG, Bartek J, Lukas J.

Nature. 2001 Apr 12;410(6830):842-7.


CK1ε targets Cdc25A for ubiquitin-mediated proteolysis under normal conditions and in response to checkpoint activation.

Piao S, Lee SJ, Xu Y, Gwak J, Oh S, Park BJ, Ha NC.

Cell Cycle. 2011 Feb 1;10(3):531-7. Epub 2011 Feb 1.


Dual regulation of Cdc25A by Chk1 and p53-ATF3 in DNA replication checkpoint control.

Demidova AR, Aau MY, Zhuang L, Yu Q.

J Biol Chem. 2009 Feb 13;284(7):4132-9. doi: 10.1074/jbc.M808118200. Epub 2008 Dec 7.


Casein kinase 1 functions as both penultimate and ultimate kinase in regulating Cdc25A destruction.

Honaker Y, Piwnica-Worms H.

Oncogene. 2010 Jun 10;29(23):3324-34. doi: 10.1038/onc.2010.96. Epub 2010 Mar 29.


14-3-3gamma mediates Cdc25A proteolysis to block premature mitotic entry after DNA damage.

Kasahara K, Goto H, Enomoto M, Tomono Y, Kiyono T, Inagaki M.

EMBO J. 2010 Aug 18;29(16):2802-12. doi: 10.1038/emboj.2010.157. Epub 2010 Jul 16.


Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A.

Sørensen CS, Syljuåsen RG, Falck J, Schroeder T, Rönnstrand L, Khanna KK, Zhou BB, Bartek J, Lukas J.

Cancer Cell. 2003 Mar;3(3):247-58.


Phosphorylation at serine 75 is required for UV-mediated degradation of human Cdc25A phosphatase at the S-phase checkpoint.

Hassepass I, Voit R, Hoffmann I.

J Biol Chem. 2003 Aug 8;278(32):29824-9. Epub 2003 May 20.


ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage.

Sørensen CS, Syljuåsen RG, Lukas J, Bartek J.

Cell Cycle. 2004 Jul;3(7):941-5. Epub 2004 Jul 13.


Chk1 mediates S and G2 arrests through Cdc25A degradation in response to DNA-damaging agents.

Xiao Z, Chen Z, Gunasekera AH, Sowin TJ, Rosenberg SH, Fesik S, Zhang H.

J Biol Chem. 2003 Jun 13;278(24):21767-73. Epub 2003 Apr 3.


M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP.

Watanabe N, Arai H, Nishihara Y, Taniguchi M, Watanabe N, Hunter T, Osada H.

Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4419-24. Epub 2004 Mar 22.


Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints.

Zhao H, Watkins JL, Piwnica-Worms H.

Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):14795-800. Epub 2002 Oct 24.

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