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Results: 1 to 20 of 240

1.

Positron emission tomography microdosing: a new concept with application in tracer and early clinical drug development.

Bergström M, Grahnén A, Långström B.

Eur J Clin Pharmacol. 2003 Sep;59(5-6):357-66. Epub 2003 Aug 22. Review.

PMID:
12937873
[PubMed - indexed for MEDLINE]
2.

Big physics, small doses: the use of AMS and PET in human microdosing of development drugs.

Lappin G, Garner RC.

Nat Rev Drug Discov. 2003 Mar;2(3):233-40. Review.

PMID:
12612650
[PubMed - indexed for MEDLINE]
3.

Microdosing studies in humans: the role of positron emission tomography.

Bauer M, Wagner CC, Langer O.

Drugs R D. 2008;9(2):73-81. Review.

PMID:
18298126
[PubMed - indexed for MEDLINE]
4.

Autoradiography with positron emitting isotopes in positron emission tomography tracer discovery.

Bergström M, Awad R, Estrada S, Mälman J, Lu L, Lendvai G, Bergström-Pettermann E, Långström B.

Mol Imaging Biol. 2003 Nov-Dec;5(6):390-6.

PMID:
14667493
[PubMed - indexed for MEDLINE]
5.

Microdosing, imaging biomarkers and SPECT: a multi-sided tripod to accelerate drug development.

Pauwels EK, Bergstrom K, Mariani G, Kairemo K.

Curr Pharm Des. 2009;15(9):928-34.

PMID:
19275656
[PubMed - indexed for MEDLINE]
6.

Preclinical pharmacokinetics: an approach towards safer and efficacious drugs.

Singh SS.

Curr Drug Metab. 2006 Feb;7(2):165-82. Review.

PMID:
16472106
[PubMed - indexed for MEDLINE]
7.

Fundamentals of positron emission tomography and applications in preclinical drug development.

Cherry SR.

J Clin Pharmacol. 2001 May;41(5):482-91. Review.

PMID:
11361044
[PubMed - indexed for MEDLINE]
8.

Positron emission tomography for use in microdosing studies.

Wagner CC, Müller M, Lappin G, Langer O.

Curr Opin Drug Discov Devel. 2008 Jan;11(1):104-10. Review.

PMID:
18175273
[PubMed - indexed for MEDLINE]
9.

[Development of antituberculous drugs: current status and future prospects].

Tomioka H, Namba K.

Kekkaku. 2006 Dec;81(12):753-74. Review. Japanese.

PMID:
17240921
[PubMed - indexed for MEDLINE]
10.

Smarter candidate selection--utilizing microdosing in exploratory clinical studies.

Buchan P.

Ernst Schering Res Found Workshop. 2007;(59):7-27. Review.

PMID:
17117712
[PubMed - indexed for MEDLINE]
11.

Microdosing for early biokinetic studies in humans.

Stenström K, Sydoff M, Mattsson S.

Radiat Prot Dosimetry. 2010 Apr-May;139(1-3):348-52. doi: 10.1093/rpd/ncq029. Epub 2010 Feb 18.

PMID:
20167793
[PubMed - indexed for MEDLINE]
12.

The role of positron emission tomography in the drug development of M100907, a putative antipsychotic with a novel mechanism of action.

Offord SJ, Wong DF, Nyberg S.

J Clin Pharmacol. 1999 Aug;Suppl:17S-24S. Review.

PMID:
10434243
[PubMed - indexed for MEDLINE]
13.

Predicting brain concentrations of drug using positron emission tomography and venous input: modeling of arterial-venous concentration differences.

Syvänen S, Blomquist G, Appel L, Hammarlund-Udenaes M, Långström B, Bergström M.

Eur J Clin Pharmacol. 2006 Oct;62(10):839-48. Epub 2006 Aug 8.

PMID:
16896783
[PubMed - indexed for MEDLINE]
14.

Approaches using molecular imaging technology -- use of PET in clinical microdose studies.

Wagner CC, Langer O.

Adv Drug Deliv Rev. 2011 Jun 19;63(7):539-46. doi: 10.1016/j.addr.2010.09.011. Epub 2010 Sep 29. Review.

PMID:
20887762
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Positron emission tomography in drug development and drug evaluation.

Paans AM, Vaalburg W.

Curr Pharm Des. 2000 Nov;6(16):1583-91. Review.

PMID:
10974154
[PubMed - indexed for MEDLINE]
16.

Molecular imaging with SPECT as a tool for drug development.

Gomes CM, Abrunhosa AJ, Ramos P, Pauwels EK.

Adv Drug Deliv Rev. 2011 Jun 19;63(7):547-54. doi: 10.1016/j.addr.2010.09.015. Epub 2010 Oct 8. Review.

PMID:
20933557
[PubMed - indexed for MEDLINE]
17.

Application of cardiac molecular imaging using positron emission tomography in evaluation of drug and therapeutics for cardiovascular disorders.

Yoshinaga K, Chow BJ, dekemp RA, Thorn S, Ruddy TD, Davies RA, DaSilva JN, Beanlands R.

Curr Pharm Des. 2005;11(7):903-32. Review.

PMID:
15777243
[PubMed - indexed for MEDLINE]
18.

A rational regulatory approach for positron emission tomography imaging probes: from "first in man" to NDA approval and reimbursement.

Barrio JR, Marcus CS, Hung JC, Keppler JS.

Mol Imaging Biol. 2004 Nov-Dec;6(6):361-7.

PMID:
15564146
[PubMed - indexed for MEDLINE]
19.

The role of PET scanning in determining pharmacoselective doses in oncology drug development.

Price P.

Ernst Schering Res Found Workshop. 2007;(59):185-93. Review.

PMID:
17117724
[PubMed - indexed for MEDLINE]
20.

Early microdose drug studies in human volunteers can minimise animal testing: Proceedings of a workshop organised by Volunteers in Research and Testing.

Combes RD, Berridge T, Connelly J, Eve MD, Garner RC, Toon S, Wilcox P.

Eur J Pharm Sci. 2003 May;19(1):1-11.

PMID:
12729856
[PubMed - indexed for MEDLINE]

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