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NSD1 is essential for early post-implantation development and has a catalytically active SET domain.

Rayasam GV, Wendling O, Angrand PO, Mark M, Niederreither K, Song L, Lerouge T, Hager GL, Chambon P, Losson R.

EMBO J. 2003 Jun 16;22(12):3153-63.


NSD1 PHD domains bind methylated H3K4 and H3K9 using interactions disrupted by point mutations in human sotos syndrome.

Pasillas MP, Shah M, Kamps MP.

Hum Mutat. 2011 Mar;32(3):292-8. doi: 10.1002/humu.21424.


Role for the nuclear receptor-binding SET domain protein 1 (NSD1) methyltransferase in coordinating lysine 36 methylation at histone 3 with RNA polymerase II function.

Lucio-Eterovic AK, Singh MM, Gardner JE, Veerappan CS, Rice JC, Carpenter PB.

Proc Natl Acad Sci U S A. 2010 Sep 28;107(39):16952-7. doi: 10.1073/pnas.1002653107. Epub 2010 Sep 13.


Nizp1, a novel multitype zinc finger protein that interacts with the NSD1 histone lysine methyltransferase through a unique C2HR motif.

Nielsen AL, Jørgensen P, Lerouge T, Cerviño M, Chambon P, Losson R.

Mol Cell Biol. 2004 Jun;24(12):5184-96.


NUP98-NSD1 links H3K36 methylation to Hox-A gene activation and leukaemogenesis.

Wang GG, Cai L, Pasillas MP, Kamps MP.

Nat Cell Biol. 2007 Jul;9(7):804-12. Epub 2007 Jun 24.


Substrate specificity analysis and novel substrates of the protein lysine methyltransferase NSD1.

Kudithipudi S, Lungu C, Rathert P, Happel N, Jeltsch A.

Chem Biol. 2014 Feb 20;21(2):226-37. doi: 10.1016/j.chembiol.2013.10.016. Epub 2014 Jan 9.


Unsafe SETs: histone lysine methyltransferases and cancer.

Schneider R, Bannister AJ, Kouzarides T.

Trends Biochem Sci. 2002 Aug;27(8):396-402. Review.


Molecular cloning of ESET, a novel histone H3-specific methyltransferase that interacts with ERG transcription factor.

Yang L, Xia L, Wu DY, Wang H, Chansky HA, Schubach WH, Hickstein DD, Zhang Y.

Oncogene. 2002 Jan 3;21(1):148-52.


The structure of NSD1 reveals an autoregulatory mechanism underlying histone H3K36 methylation.

Qiao Q, Li Y, Chen Z, Wang M, Reinberg D, Xu RM.

J Biol Chem. 2011 Mar 11;286(10):8361-8. doi: 10.1074/jbc.M110.204115. Epub 2010 Dec 31.


Structural insights into the regulation and the recognition of histone marks by the SET domain of NSD1.

Morishita M, di Luccio E.

Biochem Biophys Res Commun. 2011 Aug 26;412(2):214-9. doi: 10.1016/j.bbrc.2011.07.061. Epub 2011 Jul 22.


Histone H3-K9 methyltransferase ESET is essential for early development.

Dodge JE, Kang YK, Beppu H, Lei H, Li E.

Mol Cell Biol. 2004 Mar;24(6):2478-86.


Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain.

Feng Q, Wang H, Ng HH, Erdjument-Bromage H, Tempst P, Struhl K, Zhang Y.

Curr Biol. 2002 Jun 25;12(12):1052-8.


Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formation.

Nishioka K, Chuikov S, Sarma K, Erdjument-Bromage H, Allis CD, Tempst P, Reinberg D.

Genes Dev. 2002 Feb 15;16(4):479-89.


Molecular characterization of NSD1, a human homologue of the mouse Nsd1 gene.

Kurotaki N, Harada N, Yoshiura K, Sugano S, Niikawa N, Matsumoto N.

Gene. 2001 Nov 28;279(2):197-204.


Purification and functional characterization of SET8, a nucleosomal histone H4-lysine 20-specific methyltransferase.

Fang J, Feng Q, Ketel CS, Wang H, Cao R, Xia L, Erdjument-Bromage H, Tempst P, Simon JA, Zhang Y.

Curr Biol. 2002 Jul 9;12(13):1086-99.


A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin.

Schotta G, Lachner M, Sarma K, Ebert A, Sengupta R, Reuter G, Reinberg D, Jenuwein T.

Genes Dev. 2004 Jun 1;18(11):1251-62. Epub 2004 May 14.


Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins.

Lachner M, O'Carroll D, Rea S, Mechtler K, Jenuwein T.

Nature. 2001 Mar 1;410(6824):116-20.


Functional analysis of the N- and C-terminus of mammalian G9a histone H3 methyltransferase.

Estève PO, Patnaik D, Chin HG, Benner J, Teitell MA, Pradhan S.

Nucleic Acids Res. 2005 Jun 6;33(10):3211-23. Print 2005.


Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein.

Kuzmichev A, Nishioka K, Erdjument-Bromage H, Tempst P, Reinberg D.

Genes Dev. 2002 Nov 15;16(22):2893-905.

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