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Results: 1 to 20 of 300

1.

The activity of camptothecin analogues is enhanced in histocultures of human tumors and human tumor xenografts by modulation of extracellular pH.

Flowers JL, Hoffman RM, Driscoll TA, Wall ME, Wani MC, Manikumar G, Friedman HS, Dewhirst M, Colvin OM, Adams DJ.

Cancer Chemother Pharmacol. 2003 Sep;52(3):253-61. Epub 2003 Jun 3.

PMID:
12783198
[PubMed - indexed for MEDLINE]
2.

Camptothecin analogues with enhanced antitumor activity at acidic pH.

Adams DJ, Dewhirst MW, Flowers JL, Gamcsik MP, Colvin OM, Manikumar G, Wani MC, Wall ME.

Cancer Chemother Pharmacol. 2000;46(4):263-71.

PMID:
11052623
[PubMed - indexed for MEDLINE]
3.

Thrombospondin-1 plus irinotecan: a novel antiangiogenic-chemotherapeutic combination that inhibits the growth of advanced human colon tumor xenografts in mice.

Allegrini G, Goulette FA, Darnowski JW, Calabresi P.

Cancer Chemother Pharmacol. 2004 Mar;53(3):261-6. Epub 2003 Dec 5.

PMID:
14658007
[PubMed - indexed for MEDLINE]
4.

Antitumor effect of DX-8951, a novel camptothecin analog, on human pancreatic tumor cells and their CPT-11-resistant variants cultured in vitro and xenografted into nude mice.

Takiguchi S, Kumazawa E, Shimazoe T, Tohgo A, Kono A.

Jpn J Cancer Res. 1997 Aug;88(8):760-9. Erratum in: Jpn J Cancer Res 1997 Sep;88(9):919.

PMID:
9330608
[PubMed - indexed for MEDLINE]
5.

Complete regression of xenografted human carcinomas by camptothecin analogue-carboxymethyl dextran conjugate (T-0128).

Okuno S, Harada M, Yano T, Yano S, Kiuchi S, Tsuda N, Sakamura Y, Imai J, Kawaguchi T, Tsujihara K.

Cancer Res. 2000 Jun 1;60(11):2988-95.

PMID:
10850447
[PubMed - indexed for MEDLINE]
Free Article
6.

Water soluble 20(S)-glycinate esters of 10,11-methylenedioxycamptothecins are highly active against human breast cancer xenografts.

Wadkins RM, Potter PM, Vladu B, Marty J, Mangold G, Weitman S, Manikumar G, Wani MC, Wall ME, Von Hoff DD.

Cancer Res. 1999 Jul 15;59(14):3424-8.

PMID:
10416605
[PubMed - indexed for MEDLINE]
Free Article
7.

Camptothecin analogs with enhanced activity against human breast cancer cells. II. Impact of the tumor pH gradient.

Adams DJ, Wahl ML, Flowers JL, Sen B, Colvin M, Dewhirst MW, Manikumar G, Wani MC.

Cancer Chemother Pharmacol. 2006 Jan;57(2):145-54. Epub 2005 Jul 5.

PMID:
16001167
[PubMed - indexed for MEDLINE]
8.

Novel delivery of SN38 markedly inhibits tumor growth in xenografts, including a camptothecin-11-refractory model.

Sapra P, Zhao H, Mehlig M, Malaby J, Kraft P, Longley C, Greenberger LM, Horak ID.

Clin Cancer Res. 2008 Mar 15;14(6):1888-96. doi: 10.1158/1078-0432.CCR-07-4456.

PMID:
18347192
[PubMed - indexed for MEDLINE]
Free Article
9.

Cellular pharmacokinetics and cytotoxicity of camptothecin and topotecan at normal and acidic pH.

Gabr A, Kuin A, Aalders M, El-Gawly H, Smets LA.

Cancer Res. 1997 Nov 1;57(21):4811-6.

PMID:
9354443
[PubMed - indexed for MEDLINE]
Free Article
10.

Pattern of antitumor activity of a novel camptothecin, ST1481, in a large panel of human tumor xenografts.

Pratesi G, De Cesare M, Carenini N, Perego P, Righetti SC, Cucco C, Merlini L, Pisano C, Penco S, Carminati P, Vesci L, Zunino F.

Clin Cancer Res. 2002 Dec;8(12):3904-9.

PMID:
12473606
[PubMed - indexed for MEDLINE]
Free Article
11.

New highly lipophilic camptothecin BNP1350 is an effective drug in experimental human cancer.

Van Hattum AH, Pinedo HM, Schlüper HM, Hausheer FH, Boven E.

Int J Cancer. 2000 Oct 15;88(2):260-6.

PMID:
11004678
[PubMed - indexed for MEDLINE]
12.

Pharmacokinetics and biodistribution of the camptothecin-polymer conjugate IT-101 in rats and tumor-bearing mice.

Schluep T, Cheng J, Khin KT, Davis ME.

Cancer Chemother Pharmacol. 2006 May;57(5):654-62. Epub 2005 Aug 26.

PMID:
16133526
[PubMed - indexed for MEDLINE]
14.

MEN4901/T-0128, a new camptothecin derivative-carboxymethyldextran conjugate, has potent antitumor activities in a panel of human tumor xenografts in nude mice.

Fujita F, Koike M, Fujita M, Sakamoto Y, Okuno S, Kawaguchi T, Yano S, Yano T, Kiuchi S, Fujiwara T, Kudoh S, Kakushima M.

Clin Cancer Res. 2005 Feb 15;11(4):1650-7.

PMID:
15746070
[PubMed - indexed for MEDLINE]
Free Article
15.

Antitumor activity of a camptothecin derivative, CPT-11, against human tumor xenografts in nude mice.

Kawato Y, Furuta T, Aonuma M, Yasuoka M, Yokokura T, Matsumoto K.

Cancer Chemother Pharmacol. 1991;28(3):192-8.

PMID:
1855276
[PubMed - indexed for MEDLINE]
16.

Pre-clinical evaluation of SN-38 and novel camptothecin analogs against human chronic B-cell lymphocytic leukemia lymphocytes.

Cohen DP, Adams DJ, Flowers JL, Wall ME, Wani MC, Manikumar G, Colvin OM, Silber R.

Leuk Res. 1999 Nov;23(11):1061-70.

PMID:
10576512
[PubMed - indexed for MEDLINE]
17.

BACPTDP: a water-soluble camptothecin pro-drug with enhanced activity in hypoxic/acidic tumors.

Adams DJ, Waud WR, Wani MC, Manikumar G, Flowers JL, Driscoll TA, Morgan LR.

Cancer Chemother Pharmacol. 2011 Apr;67(4):855-65. doi: 10.1007/s00280-010-1388-8. Epub 2010 Jun 22.

PMID:
20567829
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Potent and broad antitumor effects of DX-8951f, a water-soluble camptothecin derivative, against various human tumors xenografted in nude mice.

Kumazawa E, Jimbo T, Ochi Y, Tohgo A.

Cancer Chemother Pharmacol. 1998;42(3):210-20.

PMID:
9685056
[PubMed - indexed for MEDLINE]
19.

Structure-activity relationship of alkyl camptothecin esters.

Cao Z, Pantazis P, Mendoza J, Early J, Kozielski A, Harris N, Vardeman D, Liehr J, Stehlin JS, Giovanella B.

Ann N Y Acad Sci. 2000;922:122-35.

PMID:
11193888
[PubMed - indexed for MEDLINE]
20.

Camptothecin poly[n-(2-hydroxypropyl) methacrylamide] copolymers in antitopoisomerase-I tumor therapy: intratumor release and antitumor efficacy.

Zamai M, VandeVen M, Farao M, Gratton E, Ghiglieri A, Castelli MG, Fontana E, D'Argy R, Fiorino A, Pesenti E, Suarato A, Caiolfa VR.

Mol Cancer Ther. 2003 Jan;2(1):29-40.

PMID:
12533670
[PubMed - indexed for MEDLINE]
Free Article
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