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Results: 1 to 20 of 123

1.

Impact of genetic background on development of hyperinsulinemia and diabetes in insulin receptor/insulin receptor substrate-1 double heterozygous mice.

Kulkarni RN, Almind K, Goren HJ, Winnay JN, Ueki K, Okada T, Kahn CR.

Diabetes. 2003 Jun;52(6):1528-34.

PMID:
12765966
[PubMed - indexed for MEDLINE]
Free Article
2.

Identification of interactive loci linked to insulin and leptin in mice with genetic insulin resistance.

Almind K, Kulkarni RN, Lannon SM, Kahn CR.

Diabetes. 2003 Jun;52(6):1535-43.

PMID:
12765967
[PubMed - indexed for MEDLINE]
Free Article
3.

Development of non-insulin-dependent diabetes mellitus in the double knockout mice with disruption of insulin receptor substrate-1 and beta cell glucokinase genes. Genetic reconstitution of diabetes as a polygenic disease.

Terauchi Y, Iwamoto K, Tamemoto H, Komeda K, Ishii C, Kanazawa Y, Asanuma N, Aizawa T, Akanuma Y, Yasuda K, Kodama T, Tobe K, Yazaki Y, Kadowaki T.

J Clin Invest. 1997 Mar 1;99(5):861-6.

PMID:
9062343
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Genetic modifiers of the insulin resistance phenotype in mice.

Kido Y, Philippe N, Schäffer AA, Accili D.

Diabetes. 2000 Apr;49(4):589-96.

PMID:
10871196
[PubMed - indexed for MEDLINE]
5.

Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles.

Brüning JC, Winnay J, Bonner-Weir S, Taylor SI, Accili D, Kahn CR.

Cell. 1997 Feb 21;88(4):561-72.

PMID:
9038347
[PubMed - indexed for MEDLINE]
Free Article
6.

Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2.

Kido Y, Burks DJ, Withers D, Bruning JC, Kahn CR, White MF, Accili D.

J Clin Invest. 2000 Jan;105(2):199-205.

PMID:
10642598
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Protein-tyrosine phosphatase 1B deficiency reduces insulin resistance and the diabetic phenotype in mice with polygenic insulin resistance.

Xue B, Kim YB, Lee A, Toschi E, Bonner-Weir S, Kahn CR, Neel BG, Kahn BB.

J Biol Chem. 2007 Aug 17;282(33):23829-40. Epub 2007 Jun 1.

PMID:
17545163
[PubMed - indexed for MEDLINE]
Free Article
8.

Ontogenetic characteristics of enzyme activities and plasma metabolites in C57BL/6J:Jcl mice deficient in insulin receptor substrate 2.

Hashimoto H, Arai T, Takeguchi A, Hioki K, Ohnishi Y, Kawai K, Ito M, Suzuki R, Yamauchi T, Ohsugi M, Saito M, Ueyama Y, Tobe K, Kadowaki T, Tamaoki N, Kosaka K.

Comp Med. 2006 Jun;56(3):176-87.

PMID:
16774126
[PubMed - indexed for MEDLINE]
9.

Disease model: hyperinsulinemia and insulin resistance. Part A-targeted disruption of insulin signaling or glucose transport.

Sone H, Suzuki H, Takahashi A, Yamada N.

Trends Mol Med. 2001 Jul;7(7):320-2. Review.

PMID:
11425641
[PubMed - indexed for MEDLINE]
10.
11.

Phenotypes of IRS-2 deficient mice produced by reproductive technology are stable.

Hashimoto H, Arai T, Ohnishi Y, Eto T, Ito M, Hioki K, Suzuki R, Yamauchi T, Ohsugi M, Saito M, Ueyama Y, Tobe K, Kadowaki T, Tamaoki N, Kosaka K.

Exp Anim. 2007 Apr;56(2):149-54.

PMID:
17460360
[PubMed - indexed for MEDLINE]
Free Article
12.

Liver-specific IGF-I gene deficient mice exhibit accelerated diabetes in response to streptozotocin, associated with early onset of insulin resistance.

Yu R, Yakar S, Liu YL, Lu Y, LeRoith D, Miao D, Liu JL.

Mol Cell Endocrinol. 2003 Jun 30;204(1-2):31-42.

PMID:
12850279
[PubMed - indexed for MEDLINE]
13.

Insulin resistance and hyperinsulinaemia in insulin receptor substrate-1 knockout mice.

Jenkins AB, Storlien LH.

Diabetologia. 1997 Sep;40(9):1113-4. No abstract available.

PMID:
9300252
[PubMed - indexed for MEDLINE]
14.

Knockout mice challenge our concepts of glucose homeostasis and the pathogenesis of diabetes mellitus.

Kahn CR, Brüning JC, Michael MD, Kulkarni RN.

J Pediatr Endocrinol Metab. 2000;13 Suppl 6:1377-84. Review.

PMID:
11202213
[PubMed - indexed for MEDLINE]
15.

Analysis of compensatory beta-cell response in mice with combined mutations of Insr and Irs2.

Kim JJ, Kido Y, Scherer PE, White MF, Accili D.

Am J Physiol Endocrinol Metab. 2007 Jun;292(6):E1694-701. Epub 2007 Feb 13.

PMID:
17299086
[PubMed - indexed for MEDLINE]
Free Article
16.

Lipoatrophic diabetes in Irs1(-/-)/Irs3(-/-) double knockout mice.

Laustsen PG, Michael MD, Crute BE, Cohen SE, Ueki K, Kulkarni RN, Keller SR, Lienhard GE, Kahn CR.

Genes Dev. 2002 Dec 15;16(24):3213-22.

PMID:
12502742
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Evidence for a circulating islet cell growth factor in insulin-resistant states.

Flier SN, Kulkarni RN, Kahn CR.

Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7475-80. Epub 2001 Jun 12.

PMID:
11404474
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Hyperinsulinemia but no diabetes in transgenic mice homozygously expressing the tyrosine kinase-deficient human insulin receptor.

Wang L, Muromoto N, Hayashi H, Mitani Y, Uehara H, Izumi K, Ebina Y.

Biochem Biophys Res Commun. 1997 Nov 17;240(2):446-51.

PMID:
9388499
[PubMed - indexed for MEDLINE]
19.

Control of expression of insulin resistance and hyperglycemia by different genetic factors in diabetic C57BL/6J mice.

Surwit RS, Seldin MF, Kuhn CM, Cochrane C, Feinglos MN.

Diabetes. 1991 Jan;40(1):82-7.

PMID:
2015977
[PubMed - indexed for MEDLINE]
20.

Insulin effect during embryogenesis determines fetal growth: a possible molecular link between birth weight and susceptibility to type 2 diabetes.

Terauchi Y, Kubota N, Tamemoto H, Sakura H, Nagai R, Akanuma Y, Kimura S, Kadowaki T.

Diabetes. 2000 Jan;49(1):82-6.

PMID:
10615953
[PubMed - indexed for MEDLINE]

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