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Items: 1 to 20 of 116

1.

Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration.

Selkoe D, Kopan R.

Annu Rev Neurosci. 2003;26:565-97. Epub 2003 Apr 18. Review.

PMID:
12730322
2.

Implication of APP secretases in notch signaling.

Hartmann D, Tournoy J, Saftig P, Annaert W, De Strooper B.

J Mol Neurosci. 2001 Oct;17(2):171-81. Review.

PMID:
11816790
3.

Gamma-secretase--intramembrane protease with a complex.

Wolfe MS.

Sci Aging Knowledge Environ. 2003 Mar 19;2003(11):PE7.

PMID:
12844518
4.

Role of presenilin in gamma-secretase cleavage of amyloid precursor protein.

Xia W.

Exp Gerontol. 2000 Jul;35(4):453-60. Review.

PMID:
10959033
5.

Presenilin, Notch, and the genesis and treatment of Alzheimer's disease.

Selkoe DJ.

Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11039-41. Review.

6.

Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease.

Wolfe MS, De Los Angeles J, Miller DD, Xia W, Selkoe DJ.

Biochemistry. 1999 Aug 31;38(35):11223-30. Review.

PMID:
10471271
8.

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.

De Strooper B, Annaert W, Cupers P, Saftig P, Craessaerts K, Mumm JS, Schroeter EH, Schrijvers V, Wolfe MS, Ray WJ, Goate A, Kopan R.

Nature. 1999 Apr 8;398(6727):518-22.

PMID:
10206645
9.

APP, Notch, and presenilin: molecular pieces in the puzzle of Alzheimer's disease.

Wolfe MS.

Int Immunopharmacol. 2002 Dec;2(13-14):1919-29. Review.

PMID:
12489805
10.

Intramembrane proteolysis by presenilins.

Steiner H, Haass C.

Nat Rev Mol Cell Biol. 2000 Dec;1(3):217-24. Review.

PMID:
11252897
11.

Alleles at the Nicastrin locus modify presenilin 1- deficiency phenotype.

Rozmahel R, Mount HT, Chen F, Nguyen V, Huang J, Erdebil S, Liauw J, Yu G, Hasegawa H, Gu Y, Song YQ, Schmidt SD, Nixon RA, Mathews PM, Bergeron C, Fraser P, Westaway D, St George-Hyslop P.

Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14452-7. Epub 2002 Oct 18.

12.

Gamma-secretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage.

Chyung JH, Raper DM, Selkoe DJ.

J Biol Chem. 2005 Feb 11;280(6):4383-92. Epub 2004 Nov 29.

14.

Got RIP? Presenilin-dependent intramembrane proteolysis in growth factor receptor signaling.

Landman N, Kim TW.

Cytokine Growth Factor Rev. 2004 Oct;15(5):337-51. Review.

PMID:
15450250
15.

The presenilins in Alzheimer's disease--proteolysis holds the key.

Haass C, De Strooper B.

Science. 1999 Oct 29;286(5441):916-9. Review.

PMID:
10542139
16.

Requirement for presenilin 1 in facilitating lagged 2-mediated endoproteolysis and signaling of notch 1.

Martys-Zage JL, Kim SH, Berechid B, Bingham SJ, Chu S, Sklar J, Nye J, Sisodia SS.

J Mol Neurosci. 2000 Dec;15(3):189-204.

PMID:
11303783
17.

Presenilin interactions and Alzheimer's disease.

Kosik KS.

Science. 1998 Jan 23;279(5350):463-5. No abstract available.

PMID:
9454341
18.

The gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds Numb and inhibits Notch signaling.

Roncarati R, Sestan N, Scheinfeld MH, Berechid BE, Lopez PA, Meucci O, McGlade JC, Rakic P, D'Adamio L.

Proc Natl Acad Sci U S A. 2002 May 14;99(10):7102-7.

19.
20.

Intramembrane proteolysis by presenilin and presenilin-like proteases.

Xia W, Wolfe MS.

J Cell Sci. 2003 Jul 15;116(Pt 14):2839-44. Review.

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