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Items: 1 to 20 of 140

1.

Fyn binds to and phosphorylates the kidney slit diaphragm component Nephrin.

Verma R, Wharram B, Kovari I, Kunkel R, Nihalani D, Wary KK, Wiggins RC, Killen P, Holzman LB.

J Biol Chem. 2003 Jun 6;278(23):20716-23. Epub 2003 Mar 31. Erratum in: J Biol Chem. 2005 Jul 15;280(28):26640.

2.

SRC-family kinase Fyn phosphorylates the cytoplasmic domain of nephrin and modulates its interaction with podocin.

Li H, Lemay S, Aoudjit L, Kawachi H, Takano T.

J Am Soc Nephrol. 2004 Dec;15(12):3006-15.

3.

Nephrin ectodomain engagement results in Src kinase activation, nephrin phosphorylation, Nck recruitment, and actin polymerization.

Verma R, Kovari I, Soofi A, Nihalani D, Patrie K, Holzman LB.

J Clin Invest. 2006 May;116(5):1346-59. Epub 2006 Mar 16.

4.

Nephrin and Neph1 co-localize at the podocyte foot process intercellular junction and form cis hetero-oligomers.

Barletta GM, Kovari IA, Verma RK, Kerjaschki D, Holzman LB.

J Biol Chem. 2003 May 23;278(21):19266-71. Epub 2003 Mar 19.

5.

Direct regulation of nephrin tyrosine phosphorylation by Nck adaptor proteins.

New LA, Keyvani Chahi A, Jones N.

J Biol Chem. 2013 Jan 18;288(3):1500-10. doi: 10.1074/jbc.M112.439463. Epub 2012 Nov 27.

6.

Phosphorylation of Nephrin Triggers Ca2+ Signaling by Recruitment and Activation of Phospholipase C-{gamma}1.

Harita Y, Kurihara H, Kosako H, Tezuka T, Sekine T, Igarashi T, Ohsawa I, Ohta S, Hattori S.

J Biol Chem. 2009 Mar 27;284(13):8951-62. doi: 10.1074/jbc.M806851200. Epub 2009 Jan 29.

7.

Fyn is required for oxidative- and hyperosmotic-stress-induced tyrosine phosphorylation of caveolin-1.

Sanguinetti AR, Cao H, Corley Mastick C.

Biochem J. 2003 Nov 15;376(Pt 1):159-68.

8.

Neph1, a component of the kidney slit diaphragm, is tyrosine-phosphorylated by the Src family tyrosine kinase and modulates intracellular signaling by binding to Grb2.

Harita Y, Kurihara H, Kosako H, Tezuka T, Sekine T, Igarashi T, Hattori S.

J Biol Chem. 2008 Apr 4;283(14):9177-86. doi: 10.1074/jbc.M707247200. Epub 2008 Feb 7.

9.

The Src family kinase Yes triggers hyperosmotic activation of the epidermal growth factor receptor and CD95.

Reinehr R, Becker S, Höngen A, Haüssinger D.

J Biol Chem. 2004 Jun 4;279(23):23977-87. Epub 2004 Mar 23. Erratum in: J Biol Chem. 2004 Jul 23;279(30):31990.

10.

Fyn tyrosine kinase is a critical regulator of disabled-1 during brain development.

Arnaud L, Ballif BA, Förster E, Cooper JA.

Curr Biol. 2003 Jan 8;13(1):9-17.

11.
12.

Identification of PSD-93 as a substrate for the Src family tyrosine kinase Fyn.

Nada S, Shima T, Yanai H, Husi H, Grant SG, Okada M, Akiyama T.

J Biol Chem. 2003 Nov 28;278(48):47610-21. Epub 2003 Sep 16.

13.
14.

Src family kinases are required for integrin but not PDGFR signal transduction.

Klinghoffer RA, Sachsenmaier C, Cooper JA, Soriano P.

EMBO J. 1999 May 4;18(9):2459-71.

15.

Protein tyrosine phosphatase epsilon activates Yes and Fyn in Neu-induced mammary tumor cells.

Granot-Attas S, Elson A.

Exp Cell Res. 2004 Mar 10;294(1):236-43.

PMID:
14980517
16.

Induction of tumor formation and cell transformation by polyoma middle T antigen in the absence of Src.

Thomas JE, Aguzzi A, Soriano P, Wagner EF, Brugge JS.

Oncogene. 1993 Sep;8(9):2521-9.

PMID:
7689725
17.

Podocyte slit-diaphragm protein nephrin is linked to the actin cytoskeleton.

Yuan H, Takeuchi E, Salant DJ.

Am J Physiol Renal Physiol. 2002 Apr;282(4):F585-91.

18.

ERK1/2 regulates ANG II-dependent cell proliferation via cytoplasmic activation of RSK2 and nuclear activation of elk1.

Godeny MD, Sayeski PP.

Am J Physiol Cell Physiol. 2006 Dec;291(6):C1308-17. Epub 2006 May 24.

19.

Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl, a binding site for phosphatidylinositol 3-kinase.

Hunter S, Burton EA, Wu SC, Anderson SM.

J Biol Chem. 1999 Jan 22;274(4):2097-106.

20.

Shp2 Associates with and Enhances Nephrin Tyrosine Phosphorylation and Is Necessary for Foot Process Spreading in Mouse Models of Podocyte Injury.

Verma R, Venkatareddy M, Kalinowski A, Patel SR, Salant DJ, Garg P.

Mol Cell Biol. 2015 Dec 7;36(4):596-614. doi: 10.1128/MCB.00956-15.

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