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Items: 1 to 20 of 197

1.

Pyridazinones as selective cyclooxygenase-2 inhibitors.

Li CS, Brideau C, Chan CC, Savoie C, Claveau D, Charleson S, Gordon R, Greig G, Gauthier JY, Lau CK, Riendeau D, Thérien M, Wong E, Prasit P.

Bioorg Med Chem Lett. 2003 Feb 24;13(4):597-600.

PMID:
12639538
2.

3-O-substituted benzyl pyridazinone derivatives as COX inhibitors.

Chintakunta VK, Akella V, Vedula MS, Mamnoor PK, Mishra P, Casturi SR, Vangoori A, Rajagopalan R.

Eur J Med Chem. 2002 Apr;37(4):339-47.

PMID:
11960669
3.

Thalidomide and its analogues as cyclooxygenase inhibitors.

Noguchi T, Shimazawa R, Nagasawa K, Hashimoto Y.

Bioorg Med Chem Lett. 2002 Apr 8;12(7):1043-6.

PMID:
11909713
4.

2,2-Dimethyl-4,5-diaryl-3(2H)furanone derivatives as selective cyclo-oxygenase-2 inhibitors.

Shin SS, Noh MS, Byun YJ, Choi JK, Kim JY, Lim KM, Ha JY, Kim JK, Lee CH, Chung S.

Bioorg Med Chem Lett. 2001 Jan 22;11(2):165-8.

PMID:
11206450
5.

1,2-Diarylpyrroles as potent and selective inhibitors of cyclooxygenase-2.

Khanna IK, Weier RM, Yu Y, Collins PW, Miyashiro JM, Koboldt CM, Veenhuizen AW, Currie JL, Seibert K, Isakson PC.

J Med Chem. 1997 May 23;40(11):1619-33.

PMID:
9171872
7.

Identification of 2,3-diaryl-pyrazolo[1,5-b]pyridazines as potent and selective cyclooxygenase-2 inhibitors.

Beswick P, Bingham S, Bountra C, Brown T, Browning K, Campbell I, Chessell I, Clayton N, Collins S, Corfield J, Guntrip S, Haslam C, Lambeth P, Lucas F, Mathews N, Murkit G, Naylor A, Pegg N, Pickup E, Player H, Price H, Stevens A, Stratton S, Wiseman J.

Bioorg Med Chem Lett. 2004 Nov 1;14(21):5445-8.

PMID:
15454242
8.

ABT-963 [2-(3,4-difluoro-phenyl)-4-(3-hydroxy-3-methyl-butoxy)-5-(4-methanesulfonyl-phenyl)-2H-pyridazin-3-one], a highly potent and selective disubstituted pyridazinone cyclooxgenase-2 inhibitor.

Harris RR, Black L, Surapaneni S, Kolasa T, Majest S, Namovic MT, Grayson G, Komater V, Wilcox D, King L, Marsh K, Jarvis MF, Nuss M, Nellans H, Pruesser L, Reinhart GA, Cox B, Jacobson P, Stewart A, Coghlan M, Carter G, Bell RL.

J Pharmacol Exp Ther. 2004 Dec;311(3):904-12. Epub 2004 Jul 26.

9.

4-Aryl/cycloalkyl-5-phenyloxazole derivatives as selective COX-2 inhibitors.

Hashimoto H, Maeda K, Ozawa K, Haruta J, Wakitani K.

Bioorg Med Chem Lett. 2002 Jan 7;12(1):65-8.

PMID:
11738574
10.

Investigations of new pyridazinone derivatives for the synthesis of potent analgesic and anti-inflammatory compounds with cyclooxygenase inhibitory activity.

Okçelik B, Unlü S, Banoglu E, Küpeli E, Yeşilada E, Sahin MF.

Arch Pharm (Weinheim). 2003 Sep;336(9):406-12.

PMID:
14528488
11.

Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 2. 1,3,4- and 1,2,4-thiadiazole series.

Song Y, Connor DT, Sercel AD, Sorenson RJ, Doubleday R, Unangst PC, Roth BD, Beylin VG, Gilbertsen RB, Chan K, Schrier DJ, Guglietta A, Bornemeier DA, Dyer RD.

J Med Chem. 1999 Apr 8;42(7):1161-9.

PMID:
10197960
12.

Amide derivatives of meclofenamic acid as selective cyclooxygenase-2 inhibitors.

Kalgutkar AS, Rowlinson SW, Crews BC, Marnett LJ.

Bioorg Med Chem Lett. 2002 Feb 25;12(4):521-4.

PMID:
11844663
13.

Antiinflammatory 2-benzyl-4-sulfonyl-4H-isoquinoline-1,3-diones: novel inhibitors of COX-2.

Lazer ES, Sorcek R, Cywin CL, Thome D, Possanza GJ, Graham AG, Churchill L.

Bioorg Med Chem Lett. 1998 May 19;8(10):1181-6.

PMID:
9871731
14.

2-Pyridinyl-3-(4-methylsulfonyl)phenylpyridines: selective and orally active cyclooxygenase-2 inhibitors.

Friesen RW, Brideau C, Chan CC, Charleson S, Deschênes D, Dubé D, Ethier D, Fortin R, Gauthier JY, Girard Y, Gordon R, Greig GM, Riendeau D, Savoie C, Wang Z, Wong E, Visco D, Xu LJ, Young RN.

Bioorg Med Chem Lett. 1998 Oct 6;8(19):2777-82.

PMID:
9873621
15.

Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 1. Thiazolone and oxazolone series.

Song Y, Connor DT, Doubleday R, Sorenson RJ, Sercel AD, Unangst PC, Roth BD, Gilbertsen RB, Chan K, Schrier DJ, Guglietta A, Bornemeier DA, Dyer RD.

J Med Chem. 1999 Apr 8;42(7):1151-60.

PMID:
10197959
16.

2,3-Diarylbenzopyran derivatives as a novel class of selective cyclooxygenase-2 inhibitors.

Hyup YH, Kwan JK, Kang SH, Noh MS, Ha JY, Kyu JK, Min KM, Hoon CH, Chung S.

Bioorg Med Chem Lett. 2003 Feb 10;13(3):413-7.

PMID:
12565941
17.

Aryl-substituted methyleneaminoxymethyl (MAOM) analogues of diarylcyclopentenyl cyclooxygenase-2 inhibitors: effects of some structural modifications on their biological properties.

Balsamo A, Coletta I, Guglielmotti A, Landolfi C, Lapucci A, Mancini F, Milanese C, Minutolo F, Orlandini E, Ortore G, Pinza M, Rapposelli S.

Eur J Med Chem. 2002 Jul;37(7):585-94.

PMID:
12126777
18.

Design, synthesis and biological evaluation of benzimidazole/benzothiazole and benzoxazole derivatives as cyclooxygenase inhibitors.

Paramashivappa R, Phani Kumar P, Subba Rao PV, Srinivasa Rao A.

Bioorg Med Chem Lett. 2003 Feb 24;13(4):657-60.

PMID:
12639552
19.

Synthesis and selective cyclooxygenase-2 (COX-2) inhibitory activity of a series of novel bicyclic pyrazoles.

Ranatunge RR, Garvey DS, Janero DR, Letts LG, Martino AM, Murty MG, Richardson SK, Young DV, Zemetseva IS.

Bioorg Med Chem. 2004 Mar 15;12(6):1357-66.

PMID:
15018908
20.

3-(2-Methoxytetrahydrofuran-2-yl)pyrazoles: a novel class of potent, selective cyclooxygenase-2 (COX-2) inhibitors.

Ranatunge RR, Earl RA, Garvey DS, Janero DR, Letts LG, Martino AM, Murty MG, Richardson SK, Schwalb DJ, Young DV, Zemtseva IS.

Bioorg Med Chem Lett. 2004 Dec 20;14(24):6049-52.

PMID:
15546727
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