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Items: 1 to 20 of 266


Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain.

Cua DJ, Sherlock J, Chen Y, Murphy CA, Joyce B, Seymour B, Lucian L, To W, Kwan S, Churakova T, Zurawski S, Wiekowski M, Lira SA, Gorman D, Kastelein RA, Sedgwick JD.

Nature. 2003 Feb 13;421(6924):744-8.


The power of combinatorial immunology: IL-12 and IL-12-related dimeric cytokines in infectious diseases.

Hölscher C.

Med Microbiol Immunol. 2004 Feb;193(1):1-17. Epub 2003 Jun 27. Review.


Autoimmunity: A case of mistaken identity.

Watford WT, O'Shea JJ.

Nature. 2003 Feb 13;421(6924):706-8. No abstract available.


Role of IL-12 receptor beta 1 in regulation of T cell response by APC in experimental autoimmune encephalomyelitis.

Zhang GX, Yu S, Gran B, Li J, Siglienti I, Chen X, Calida D, Ventura E, Kamoun M, Rostami A.

J Immunol. 2003 Nov 1;171(9):4485-92.


Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation.

Murphy CA, Langrish CL, Chen Y, Blumenschein W, McClanahan T, Kastelein RA, Sedgwick JD, Cua DJ.

J Exp Med. 2003 Dec 15;198(12):1951-7. Epub 2003 Dec 8.


Astrocyte-targeted expression of IL-12 induces active cellular immune responses in the central nervous system and modulates experimental allergic encephalomyelitis.

Pagenstecher A, Lassmann S, Carson MJ, Kincaid CL, Stalder AK, Campbell IL.

J Immunol. 2000 May 1;164(9):4481-92.


IL-23 provides a limited mechanism of resistance to acute toxoplasmosis in the absence of IL-12.

Lieberman LA, Cardillo F, Owyang AM, Rennick DM, Cua DJ, Kastelein RA, Hunter CA.

J Immunol. 2004 Aug 1;173(3):1887-93.


IL-23 drives a pathogenic T cell population that induces autoimmune inflammation.

Langrish CL, Chen Y, Blumenschein WM, Mattson J, Basham B, Sedgwick JD, McClanahan T, Kastelein RA, Cua DJ.

J Exp Med. 2005 Jan 17;201(2):233-40.


Pathophysiology of interleukin-23 in experimental autoimmune encephalomyelitis.

Touil T, Fitzgerald D, Zhang GX, Rostami AM, Gran B.

Drug News Perspect. 2006 Mar;19(2):77-83. Review.


IL-23 enhances the inflammatory cell response in Cryptococcus neoformans infection and induces a cytokine pattern distinct from IL-12.

Kleinschek MA, Muller U, Brodie SJ, Stenzel W, Kohler G, Blumenschein WM, Straubinger RK, McClanahan T, Kastelein RA, Alber G.

J Immunol. 2006 Jan 15;176(2):1098-106.


The critical role of IL-12p40 in initiating, enhancing, and perpetuating pathogenic events in murine experimental autoimmune neuritis.

Bao L, Lindgren JU, van der Meide P, Zhu Sw, Ljunggren HG, Zhu J.

Brain Pathol. 2002 Oct;12(4):420-9.


Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells.

Hoeve MA, Savage ND, de Boer T, Langenberg DM, de Waal Malefyt R, Ottenhoff TH, Verreck FA.

Eur J Immunol. 2006 Mar;36(3):661-70.


IL-23 production by cosecretion of endogenous p19 and transgenic p40 in keratin 14/p40 transgenic mice: evidence for enhanced cutaneous immunity.

Kopp T, Lenz P, Bello-Fernandez C, Kastelein RA, Kupper TS, Stingl G.

J Immunol. 2003 Jun 1;170(11):5438-44.


IL-23 compensates for the absence of IL-12p70 and is essential for the IL-17 response during tuberculosis but is dispensable for protection and antigen-specific IFN-gamma responses if IL-12p70 is available.

Khader SA, Pearl JE, Sakamoto K, Gilmartin L, Bell GK, Jelley-Gibbs DM, Ghilardi N, deSauvage F, Cooper AM.

J Immunol. 2005 Jul 15;175(2):788-95.


IL-23 is increased in dendritic cells in multiple sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production.

Vaknin-Dembinsky A, Balashov K, Weiner HL.

J Immunol. 2006 Jun 15;176(12):7768-74. Erratum in: J Immunol. 2006 Aug 1;177(3):2025.


Interferon-gamma production and host protective response against Mycobacterium tuberculosis in mice lacking both IL-12p40 and IL-18.

Kawakami K, Kinjo Y, Uezu K, Miyagi K, Kinjo T, Yara S, Koguchi Y, Miyazato A, Shibuya K, Iwakura Y, Takeda K, Akira S, Saito A.

Microbes Infect. 2004 Apr;6(4):339-49.

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