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Results: 1 to 20 of 418

1.

Phosphorylation of serine 1106 in the catalytic domain of topoisomerase II alpha regulates enzymatic activity and drug sensitivity.

Chikamori K, Grabowski DR, Kinter M, Willard BB, Yadav S, Aebersold RH, Bukowski RM, Hickson ID, Andersen AH, Ganapathi R, Ganapathi MK.

J Biol Chem. 2003 Apr 11;278(15):12696-702. Epub 2003 Feb 4.

PMID:
12569090
[PubMed - indexed for MEDLINE]
Free Article
2.

Attenuation of drug-stimulated topoisomerase II-DNA cleavable complex formation in wild-type HL-60 cells treated with an intracellular calcium buffer is correlated with decreased cytotoxicity and site-specific hypophosphorylation of topoisomerase IIalpha.

Aoyama M, Grabowski DR, Dubyak GR, Constantinou AI, Rybicki LA, Bukowski RM, Ganapathi MK, Hickson ID, Ganapathi R.

Biochem J. 1998 Dec 15;336 ( Pt 3):727-33.

PMID:
9841887
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Resistance to etoposide in human leukemia HL-60 cells: reduction in drug-induced DNA cleavage associated with hypophosphorylation of topoisomerase II phosphopeptides.

Ganapathi R, Constantinou A, Kamath N, Dubyak G, Grabowski D, Krivacic K.

Mol Pharmacol. 1996 Aug;50(2):243-8.

PMID:
8700130
[PubMed - indexed for MEDLINE]
4.

Tumor cell resistance to topoisomerase II poisons: role for intracellular free calcium in the sensitization by inhibitors or calcium-calmodulin-dependent enzymes.

Grabowski DR, Dubyak GR, Rybicki L, Hidaka H, Ganapathi R.

Biochem Pharmacol. 1998 Aug 1;56(3):345-9.

PMID:
9744572
[PubMed - indexed for MEDLINE]
5.

Casein kinase I delta/epsilon phosphorylates topoisomerase IIalpha at serine-1106 and modulates DNA cleavage activity.

Grozav AG, Chikamori K, Kozuki T, Grabowski DR, Bukowski RM, Willard B, Kinter M, Andersen AH, Ganapathi R, Ganapathi MK.

Nucleic Acids Res. 2009 Feb;37(2):382-92. doi: 10.1093/nar/gkn934. Epub 2008 Nov 29.

PMID:
19043076
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Altered drug interaction and regulation of topoisomerase IIbeta: potential mechanisms governing sensitivity of HL-60 cells to amsacrine and etoposide.

Grabowski DR, Holmes KA, Aoyama M, Ye Y, Rybicki LA, Bukowski RM, Ganapathi MK, Hickson ID, Ganapathi R.

Mol Pharmacol. 1999 Dec;56(6):1340-5.

PMID:
10570063
[PubMed - indexed for MEDLINE]
Free Article
7.

Phosphorylation-independent stimulation of DNA topoisomerase II alpha activity.

Kimura K, Saijo M, Tanaka M, Enomoto T.

J Biol Chem. 1996 May 3;271(18):10990-5.

PMID:
8631919
[PubMed - indexed for MEDLINE]
Free Article
8.

Human topoisomerase II alpha is phosphorylated in a cell-cycle phase-dependent manner by a proline-directed kinase.

Wells NJ, Hickson ID.

Eur J Biochem. 1995 Jul 15;231(2):491-7.

PMID:
7635160
[PubMed - indexed for MEDLINE]
Free Article
9.

Mitotic phosphorylation of DNA topoisomerase II alpha by protein kinase CK2 creates the MPM-2 phosphoepitope on Ser-1469.

Escargueil AE, Plisov SY, Filhol O, Cochet C, Larsen AK.

J Biol Chem. 2000 Nov 3;275(44):34710-8.

PMID:
10942766
[PubMed - indexed for MEDLINE]
Free Article
10.

Negative regulation of Raf-1 by phosphorylation of serine 621.

Mischak H, Seitz T, Janosch P, Eulitz M, Steen H, Schellerer M, Philipp A, Kolch W.

Mol Cell Biol. 1996 Oct;16(10):5409-18.

PMID:
8816453
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Functions of the C-terminal domain of CTP: phosphocholine cytidylyltransferase. Effects of C-terminal deletions on enzyme activity, intracellular localization and phosphorylation potential.

Cornell RB, Kalmar GB, Kay RJ, Johnson MA, Sanghera JS, Pelech SL.

Biochem J. 1995 Sep 1;310 ( Pt 2):699-708.

PMID:
7654214
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Cell cycle phase-specific phosphorylation of human topoisomerase II alpha. Evidence of a role for protein kinase C.

Wells NJ, Fry AM, Guano F, Norbury C, Hickson ID.

J Biol Chem. 1995 Nov 24;270(47):28357-63.

PMID:
7499337
[PubMed - indexed for MEDLINE]
Free Article
14.

Casein kinase II stabilizes the activity of human topoisomerase IIalpha in a phosphorylation-independent manner.

Redwood C, Davies SL, Wells NJ, Fry AM, Hickson ID.

J Biol Chem. 1998 Feb 6;273(6):3635-42.

PMID:
9452492
[PubMed - indexed for MEDLINE]
Free Article
15.

A novel point mutation in the 3' flanking region of the DNA-binding domain of topoisomerase II alpha associated with acquired resistance to topoisomerase II active agents.

Hashimoto S, Danks MK, Chatterjee S, Beck WT, Berger NA.

Oncol Res. 1995;7(1):21-9.

PMID:
7549041
[PubMed - indexed for MEDLINE]
16.

Transfection of a human topoisomerase II alpha gene into etoposide-resistant human breast tumor cells sensitizes the cells to etoposide.

Asano T, An T, Zwelling LA, Takano H, Fojo AT, Kleinerman ES.

Oncol Res. 1996;8(3):101-10.

PMID:
8823806
[PubMed - indexed for MEDLINE]
17.
18.

Carbamate analogues of amsacrine active against non-cycling cells: relative activity against topoisomerases IIalpha and beta.

Turnbull RM, Meczes EL, Perenna Rogers M, Lock RB, Sullivan DM, Finlay GJ, Baguley BC, Austin CA.

Cancer Chemother Pharmacol. 1999;44(4):275-82.

PMID:
10447574
[PubMed - indexed for MEDLINE]
20.

Serine 1524 is a major site of phosphorylation on human topoisomerase II alpha protein in vivo and is a substrate for casein kinase II in vitro.

Wells NJ, Addison CM, Fry AM, Ganapathi R, Hickson ID.

J Biol Chem. 1994 Nov 25;269(47):29746-51.

PMID:
7961967
[PubMed - indexed for MEDLINE]
Free Article

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