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Results: 1 to 20 of 236

1.

Biotinylated theta-toxin derivative as a probe to examine intracellular cholesterol-rich domains in normal and Niemann-Pick type C1 cells.

Sugii S, Reid PC, Ohgami N, Shimada Y, Maue RA, Ninomiya H, Ohno-Iwashita Y, Chang TY.

J Lipid Res. 2003 May;44(5):1033-41. Epub 2003 Feb 1.

PMID:
12562855
[PubMed - indexed for MEDLINE]
Free Article
2.

Selective binding of perfringolysin O derivative to cholesterol-rich membrane microdomains (rafts).

Waheed AA, Shimada Y, Heijnen HF, Nakamura M, Inomata M, Hayashi M, Iwashita S, Slot JW, Ohno-Iwashita Y.

Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):4926-31. Epub 2001 Apr 17.

PMID:
11309501
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Reduced sensitivity of Niemann-Pick C1-deficient cells to theta-toxin (perfringolysin O): sequestration of toxin to raft-enriched membrane vesicles.

Ohsaki Y, Sugimoto Y, Suzuki M, Kaidoh T, Shimada Y, Ohno-Iwashita Y, Davies JP, Ioannou YA, Ohno K, Ninomiya H.

Histochem Cell Biol. 2004 Apr;121(4):263-72. Epub 2004 Apr 7.

PMID:
15069562
[PubMed - indexed for MEDLINE]
4.

Niemann-Pick C1 protein: obligatory roles for N-terminal domains and lysosomal targeting in cholesterol mobilization.

Watari H, Blanchette-Mackie EJ, Dwyer NK, Glick JM, Patel S, Neufeld EB, Brady RO, Pentchev PG, Strauss JF 3rd.

Proc Natl Acad Sci U S A. 1999 Feb 2;96(3):805-10.

PMID:
9927649
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Gamma-secretase activity is present in rafts but is not cholesterol-dependent.

Wada S, Morishima-Kawashima M, Qi Y, Misono H, Shimada Y, Ohno-Iwashita Y, Ihara Y.

Biochemistry. 2003 Dec 2;42(47):13977-86.

PMID:
14636066
[PubMed - indexed for MEDLINE]
6.

Trafficking defects in endogenously synthesized cholesterol in fibroblasts, macrophages, hepatocytes, and glial cells from Niemann-Pick type C1 mice.

Reid PC, Sugii S, Chang TY.

J Lipid Res. 2003 May;44(5):1010-9. Epub 2003 Mar 1.

PMID:
12611909
[PubMed - indexed for MEDLINE]
Free Article
7.

Role of Niemann-Pick type C1 protein in intracellular trafficking of low density lipoprotein-derived cholesterol.

Cruz JC, Sugii S, Yu C, Chang TY.

J Biol Chem. 2000 Feb 11;275(6):4013-21.

PMID:
10660558
[PubMed - indexed for MEDLINE]
Free Article
8.

Promotion of tau phosphorylation by MAP kinase Erk1/2 is accompanied by reduced cholesterol level in detergent-insoluble membrane fraction in Niemann-Pick C1-deficient cells.

Sawamura N, Gong JS, Chang TY, Yanagisawa K, Michikawa M.

J Neurochem. 2003 Mar;84(5):1086-96.

PMID:
12603832
[PubMed - indexed for MEDLINE]
9.

Niemann-Pick C variant detection by altered sphingolipid trafficking and correlation with mutations within a specific domain of NPC1.

Sun X, Marks DL, Park WD, Wheatley CL, Puri V, O'Brien JF, Kraft DL, Lundquist PA, Patterson MC, Pagano RE, Snow K.

Am J Hum Genet. 2001 Jun;68(6):1361-72. Epub 2001 May 9.

PMID:
11349231
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Transport of plasma membrane-derived cholesterol and the function of Niemann-Pick C1 Protein.

Wiegand V, Chang TY, Strauss JF 3rd, Fahrenholz F, Gimpl G.

FASEB J. 2003 Apr;17(6):782-4. Epub 2003 Feb 19.

PMID:
12594172
[PubMed - indexed for MEDLINE]
Free Article
11.

Cholesterol overload promotes morphogenesis of a Niemann-Pick C (NPC)-like compartment independent of inhibition of NPC1 or HE1/NPC2 function.

Frolov A, Srivastava K, Daphna-Iken D, Traub LM, Schaffer JE, Ory DS.

J Biol Chem. 2001 Dec 7;276(49):46414-21. Epub 2001 Sep 24.

PMID:
11571306
[PubMed - indexed for MEDLINE]
Free Article
12.

Niemann-Pick C1 functions independently of Niemann-Pick C2 in the initial stage of retrograde transport of membrane-impermeable lysosomal cargo.

Goldman SD, Krise JP.

J Biol Chem. 2010 Feb 12;285(7):4983-94. doi: 10.1074/jbc.M109.037622. Epub 2009 Dec 10.

PMID:
20007703
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Binding between the Niemann-Pick C1 protein and a photoactivatable cholesterol analog requires a functional sterol-sensing domain.

Ohgami N, Ko DC, Thomas M, Scott MP, Chang CC, Chang TY.

Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12473-8. Epub 2004 Aug 16.

PMID:
15314240
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Perfringolysin O, a cholesterol-binding cytolysin, as a probe for lipid rafts.

Ohno-Iwashita Y, Shimada Y, Waheed AA, Hayashi M, Inomata M, Nakamura M, Maruya M, Iwashita S.

Anaerobe. 2004 Apr;10(2):125-34.

PMID:
16701509
[PubMed]
15.

Adenovirus expressing an NPC1-GFP fusion gene corrects neuronal and nonneuronal defects associated with Niemann pick type C disease.

Paul CA, Reid PC, Boegle AK, Karten B, Zhang M, Jiang ZG, Franz D, Lin L, Chang TY, Vance JE, Blanchette-Mackie J, Maue RA.

J Neurosci Res. 2005 Sep 1;81(5):706-19.

PMID:
16015597
[PubMed - indexed for MEDLINE]
16.

Cessation of rapid late endosomal tubulovesicular trafficking in Niemann-Pick type C1 disease.

Zhang M, Dwyer NK, Love DC, Cooney A, Comly M, Neufeld E, Pentchev PG, Blanchette-Mackie EJ, Hanover JA.

Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4466-71.

PMID:
11296289
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Automated microscopy screening for compounds that partially revert cholesterol accumulation in Niemann-Pick C cells.

Pipalia NH, Huang A, Ralph H, Rujoi M, Maxfield FR.

J Lipid Res. 2006 Feb;47(2):284-301. Epub 2005 Nov 15.

PMID:
16288097
[PubMed - indexed for MEDLINE]
Free Article
18.

Type C Niemann-Pick disease. Lysosomal accumulation and defective intracellular mobilization of low density lipoprotein cholesterol.

Sokol J, Blanchette-Mackie J, Kruth HS, Dwyer NK, Amende LM, Butler JD, Robinson E, Patel S, Brady RO, Comly ME, et al.

J Biol Chem. 1988 Mar 5;263(7):3411-7.

PMID:
3277970
[PubMed - indexed for MEDLINE]
Free Article
19.

Localization of the murine Niemann-Pick C1 protein to two distinct intracellular compartments.

Garver WS, Heidenreich RA, Erickson RP, Thomas MA, Wilson JM.

J Lipid Res. 2000 May;41(5):673-87.

PMID:
10787428
[PubMed - indexed for MEDLINE]
Free Article
20.

Depletion of rafts in late endocytic membranes is controlled by NPC1-dependent recycling of cholesterol to the plasma membrane.

Lusa S, Blom TS, Eskelinen EL, Kuismanen E, MÃ¥nsson JE, Simons K, Ikonen E.

J Cell Sci. 2001 May;114(Pt 10):1893-900.

PMID:
11329376
[PubMed - indexed for MEDLINE]
Free Article

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