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Deleted in liver cancer (DLC) 2 encodes a RhoGAP protein with growth suppressor function and is underexpressed in hepatocellular carcinoma.

Ching YP, Wong CM, Chan SF, Leung TH, Ng DC, Jin DY, Ng IO.

J Biol Chem. 2003 Mar 21;278(12):10824-30. Epub 2003 Jan 16.


Deleted in liver cancer 2 (DLC2) suppresses cell transformation by means of inhibition of RhoA activity.

Leung TH, Ching YP, Yam JW, Wong CM, Yau TO, Jin DY, Ng IO.

Proc Natl Acad Sci U S A. 2005 Oct 18;102(42):15207-12. Epub 2005 Oct 10.


Rho GTPase-activating protein deleted in liver cancer suppresses cell proliferation and invasion in hepatocellular carcinoma.

Wong CM, Yam JW, Ching YP, Yau TO, Leung TH, Jin DY, Ng IO.

Cancer Res. 2005 Oct 1;65(19):8861-8.


Solution structures, dynamics, and lipid-binding of the sterile alpha-motif domain of the deleted in liver cancer 2.

Li H, Fung KL, Jin DY, Chung SS, Ching YP, Ng IO, Sze KH, Ko BC, Sun H.

Proteins. 2007 Jun 1;67(4):1154-66.


Deleted in liver cancer 2 (DLC2) was dispensable for development and its deficiency did not aggravate hepatocarcinogenesis.

Yau TO, Leung TH, Lam S, Cheung OF, Tung EK, Khong PL, Lam A, Chung S, Ng IO.

PLoS One. 2009 Aug 10;4(8):e6566. doi: 10.1371/journal.pone.0006566.


Cloning, characterization, and chromosomal localization of a gene frequently deleted in human liver cancer (DLC-1) homologous to rat RhoGAP.

Yuan BZ, Miller MJ, Keck CL, Zimonjic DB, Thorgeirsson SS, Popescu NC.

Cancer Res. 1998 May 15;58(10):2196-9.


Mitochondrial targeting of growth suppressor protein DLC2 through the START domain.

Ng DC, Chan SF, Kok KH, Yam JW, Ching YP, Ng IO, Jin DY.

FEBS Lett. 2006 Jan 9;580(1):191-8. Epub 2005 Dec 9.


Genetic and epigenetic alterations of DLC-1 gene in hepatocellular carcinoma.

Wong CM, Lee JM, Ching YP, Jin DY, Ng IO.

Cancer Res. 2003 Nov 15;63(22):7646-51.


A novel growth suppressor gene on chromosome 17p13.3 with a high frequency of mutation in human hepatocellular carcinoma.

Zhao X, Li J, He Y, Lan F, Fu L, Guo J, Zhao R, Ye Y, He M, Chong W, Chen J, Zhang L, Yang N, Xu B, Wu M, Wan D, Gu J.

Cancer Res. 2001 Oct 15;61(20):7383-7.


Deleted in liver cancer 1 isoforms are distinctly expressed in human tissues, functionally different and under differential transcriptional regulation in hepatocellular carcinoma.

Ko FC, Yeung YS, Wong CM, Chan LK, Poon RT, Ng IO, Yam JW.

Liver Int. 2010 Jan;30(1):139-48. doi: 10.1111/j.1478-3231.2009.02133.x. Epub 2009 Oct 27.


DLC1: a significant GAP in the cancer genome.

Lahoz A, Hall A.

Genes Dev. 2008 Jul 1;22(13):1724-30. doi: 10.1101/gad.1691408.


Interaction of deleted in liver cancer 1 with tensin2 in caveolae and implications in tumor suppression.

Yam JW, Ko FC, Chan CY, Jin DY, Ng IO.

Cancer Res. 2006 Sep 1;66(17):8367-72.


LFIRE-1/HFREP-1, a liver-specific gene, is frequently downregulated and has growth suppressor activity in hepatocellular carcinoma.

Yan J, Yu Y, Wang N, Chang Y, Ying H, Liu W, He J, Li S, Jiang W, Li Y, Liu H, Wang H, Xu Y.

Oncogene. 2004 Mar 11;23(10):1939-49.


Deleted in liver cancer 2 suppresses cell growth via the regulation of the Raf-1-ERK1/2-p70S6K signalling pathway.

Leung TH, Yam JW, Chan LK, Ching YP, Ng IO.

Liver Int. 2010 Oct;30(9):1315-23. doi: 10.1111/j.1478-3231.2010.02307.x.


DLC-1:a Rho GTPase-activating protein and tumour suppressor.

Durkin ME, Yuan BZ, Zhou X, Zimonjic DB, Lowy DR, Thorgeirsson SS, Popescu NC.

J Cell Mol Med. 2007 Sep-Oct;11(5):1185-207. Review.


Clinical value of alterations in p73 gene, related to p53 at 1p36, in human hepatocellular carcinoma.

Aoki T, Miyamoto A, Marubashi S, Nagano H, Umeshita K, Fujiwara Y, Dono K, Nakamori S, Sakon M, Monden M.

Int J Oncol. 2004 Feb;24(2):441-6.


A novel strategy for specifically down-regulating individual Rho GTPase activity in tumor cells.

Wang L, Yang L, Luo Y, Zheng Y.

J Biol Chem. 2003 Nov 7;278(45):44617-25. Epub 2003 Aug 25.

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