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Items: 1 to 20 of 102


Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation.

Shimaoka M, Xiao T, Liu JH, Yang Y, Dong Y, Jun CD, McCormack A, Zhang R, Joachimiak A, Takagi J, Wang JH, Springer TA.

Cell. 2003 Jan 10;112(1):99-111.


Complex structure of engineered modular domains defining molecular interaction between ICAM-1 and integrin LFA-1.

Kang S, Kim CU, Gu X, Owens RM, van Rijn SJ, Boonyaleepun V, Mao Y, Springer TA, Jin MM.

PLoS One. 2012;7(8):e44124. doi: 10.1371/journal.pone.0044124. Epub 2012 Aug 30.


Ultrastructure and function of dimeric, soluble intercellular adhesion molecule-1 (ICAM-1).

Jun CD, Carman CV, Redick SD, Shimaoka M, Erickson HP, Springer TA.

J Biol Chem. 2001 Aug 3;276(31):29019-27. Epub 2001 Jun 4.


Transition from rolling to firm adhesion is regulated by the conformation of the I domain of the integrin lymphocyte function-associated antigen-1.

Salas A, Shimaoka M, Chen S, Carman CV, Springer T.

J Biol Chem. 2002 Dec 27;277(52):50255-62. Epub 2002 Oct 3.


Rational design of intercellular adhesion molecule-1 (ICAM-1) variants for antagonizing integrin lymphocyte function-associated antigen-1-dependent adhesion.

Song G, Lazar GA, Kortemme T, Shimaoka M, Desjarlais JR, Baker D, Springer TA.

J Biol Chem. 2006 Feb 24;281(8):5042-9. Epub 2005 Dec 14.


Model of the alphaLbeta2 integrin I-domain/ICAM-1 DI interface suggests that subtle changes in loop orientation determine ligand specificity.

Legge GB, Morris GM, Sanner MF, Takada Y, Olson AJ, Grynszpan F.

Proteins. 2002 Aug 1;48(2):151-60.


NMR and mutagenesis evidence for an I domain allosteric site that regulates lymphocyte function-associated antigen 1 ligand binding.

Huth JR, Olejniczak ET, Mendoza R, Liang H, Harris EA, Lupher ML Jr, Wilson AE, Fesik SW, Staunton DE.

Proc Natl Acad Sci U S A. 2000 May 9;97(10):5231-6.


Integrin inside-out signaling and the immunological synapse.

Springer TA, Dustin ML.

Curr Opin Cell Biol. 2012 Feb;24(1):107-15. doi: 10.1016/ Epub 2011 Nov 28. Review.


Importance of force linkage in mechanochemistry of adhesion receptors.

Astrof NS, Salas A, Shimaoka M, Chen J, Springer TA.

Biochemistry. 2006 Dec 19;45(50):15020-8.


Forcing switch from short- to intermediate- and long-lived states of the alphaA domain generates LFA-1/ICAM-1 catch bonds.

Chen W, Lou J, Zhu C.

J Biol Chem. 2010 Nov 12;285(46):35967-78. doi: 10.1074/jbc.M110.155770. Epub 2010 Sep 6. Erratum in: J Biol Chem. 2011 May 20;286(20):18344.


Reversibly locking a protein fold in an active conformation with a disulfide bond: integrin alphaL I domains with high affinity and antagonist activity in vivo.

Shimaoka M, Lu C, Palframan RT, von Andrian UH, McCormack A, Takagi J, Springer TA.

Proc Natl Acad Sci U S A. 2001 May 22;98(11):6009-14. Epub 2001 May 15.


Structural basis and kinetics of force-induced conformational changes of an αA domain-containing integrin.

Xiang X, Lee CY, Li T, Chen W, Lou J, Zhu C.

PLoS One. 2011;6(11):e27946. doi: 10.1371/journal.pone.0027946. Epub 2011 Nov 28.


Crystal structure of ICAM-2 reveals a distinctive integrin recognition surface.

Casasnovas JM, Springer TA, Liu JH, Harrison SC, Wang JH.

Nature. 1997 May 15;387(6630):312-5.


Transition from rolling to firm adhesion can be mimicked by extension of integrin alphaLbeta2 in an intermediate affinity state.

Salas A, Shimaoka M, Phan U, Kim M, Springer TA.

J Biol Chem. 2006 Apr 21;281(16):10876-82. Epub 2006 Feb 27.

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