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Results: 1 to 20 of 197

1.

Reversion of RhoC GTPase-induced inflammatory breast cancer phenotype by treatment with a farnesyl transferase inhibitor.

van Golen KL, Bao L, DiVito MM, Wu Z, Prendergast GC, Merajver SD.

Mol Cancer Ther. 2002 Jun;1(8):575-83.

PMID:
12479217
[PubMed - indexed for MEDLINE]
Free Article
2.

RhoC GTPase, a novel transforming oncogene for human mammary epithelial cells that partially recapitulates the inflammatory breast cancer phenotype.

van Golen KL, Wu ZF, Qiao XT, Bao LW, Merajver SD.

Cancer Res. 2000 Oct 15;60(20):5832-8.

PMID:
11059780
[PubMed - indexed for MEDLINE]
Free Article
3.

Farnesyl transferase inhibitor treatment of breast cancer cells leads to altered RhoA and RhoC GTPase activity and induces a dormant phenotype.

Chatterjee M, van Golen KL.

Int J Cancer. 2011 Jul 1;129(1):61-9. doi: 10.1002/ijc.25655. Epub 2010 Oct 26.

PMID:
20824700
[PubMed - indexed for MEDLINE]
4.

WISP3 and RhoC guanosine triphosphatase cooperate in the development of inflammatory breast cancer.

Kleer CG, Zhang Y, Pan Q, Gallagher G, Wu M, Wu ZF, Merajver SD.

Breast Cancer Res. 2004;6(1):R110-5.

PMID:
14696649
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Mitogen activated protein kinase pathway is involved in RhoC GTPase induced motility, invasion and angiogenesis in inflammatory breast cancer.

van Golen KL, Bao LW, Pan Q, Miller FR, Wu ZF, Merajver SD.

Clin Exp Metastasis. 2002;19(4):301-11.

PMID:
12090470
[PubMed - indexed for MEDLINE]
6.

WISP3 and RhoC guanosine triphosphatase cooperate in the development of inflammatory breast cancer.

Kleer CG, Zhang Y, Pan Q, Gallagher G, Wu M, Wu ZF, Merajver SD.

Breast Cancer Res. 2004;6(2):R110-5.

PMID:
15602803
[PubMed - indexed for MEDLINE]
7.

Cell growth inhibition by farnesyltransferase inhibitors is mediated by gain of geranylgeranylated RhoB.

Du W, Lebowitz PF, Prendergast GC.

Mol Cell Biol. 1999 Mar;19(3):1831-40.

PMID:
10022870
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

A novel strategy for specifically down-regulating individual Rho GTPase activity in tumor cells.

Wang L, Yang L, Luo Y, Zheng Y.

J Biol Chem. 2003 Nov 7;278(45):44617-25. Epub 2003 Aug 25.

PMID:
12939257
[PubMed - indexed for MEDLINE]
Free Article
9.

Overexpression of caveolin-1 and -2 in cell lines and in human samples of inflammatory breast cancer.

Van den Eynden GG, Van Laere SJ, Van der Auwera I, Merajver SD, Van Marck EA, van Dam P, Vermeulen PB, Dirix LY, van Golen KL.

Breast Cancer Res Treat. 2006 Feb;95(3):219-28. Epub 2005 Oct 22.

PMID:
16244790
[PubMed - indexed for MEDLINE]
10.

Transformation-selective apoptotic program triggered by farnesyltransferase inhibitors requires Bin1.

DuHadaway JB, Du W, Donover S, Baker J, Liu AX, Sharp DM, Muller AJ, Prendergast GC.

Oncogene. 2003 Jun 5;22(23):3578-88.

PMID:
12789266
[PubMed - indexed for MEDLINE]
11.

RhoC GTPase overexpression modulates induction of angiogenic factors in breast cells.

van Golen KL, Wu ZF, Qiao XT, Bao L, Merajver SD.

Neoplasia. 2000 Sep-Oct;2(5):418-25.

PMID:
11191108
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Geranylgeranylated RhoB mediates suppression of human tumor cell growth by farnesyltransferase inhibitors.

Du W, Prendergast GC.

Cancer Res. 1999 Nov 1;59(21):5492-6.

PMID:
10554025
[PubMed - indexed for MEDLINE]
Free Article
13.

Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models.

Lobell RB, Omer CA, Abrams MT, Bhimnathwala HG, Brucker MJ, Buser CA, Davide JP, deSolms SJ, Dinsmore CJ, Ellis-Hutchings MS, Kral AM, Liu D, Lumma WC, Machotka SV, Rands E, Williams TM, Graham SL, Hartman GD, Oliff AI, Heimbrook DC, Kohl NE.

Cancer Res. 2001 Dec 15;61(24):8758-68.

PMID:
11751396
[PubMed - indexed for MEDLINE]
Free Article
14.

Role for RhoB and PRK in the suppression of epithelial cell transformation by farnesyltransferase inhibitors.

Zeng PY, Rane N, Du W, Chintapalli J, Prendergast GC.

Oncogene. 2003 Feb 27;22(8):1124-34.

PMID:
12606940
[PubMed - indexed for MEDLINE]
15.
16.

Inhibition of transendothelial migration and invasion of human breast cancer cells by preventing geranylgeranylation of Rho.

Kusama T, Mukai M, Tatsuta M, Nakamura H, Inoue M.

Int J Oncol. 2006 Jul;29(1):217-23.

PMID:
16773203
[PubMed - indexed for MEDLINE]
17.

Farnesyltransferase inhibitor (L-744,832) restores TGF-beta type II receptor expression and enhances radiation sensitivity in K-ras mutant pancreatic cancer cell line MIA PaCa-2.

Alcock RA, Dey S, Chendil D, Inayat MS, Mohiuddin M, Hartman G, Chatfield LK, Gallicchio VS, Ahmed MM.

Oncogene. 2002 Nov 7;21(51):7883-90.

PMID:
12420225
[PubMed - indexed for MEDLINE]
Free Article
18.

Mouse mammary tumor virus-Ki-rasB transgenic mice develop mammary carcinomas that can be growth-inhibited by a farnesyl:protein transferase inhibitor.

Omer CA, Chen Z, Diehl RE, Conner MW, Chen HY, Trumbauer ME, Gopal-Truter S, Seeburger G, Bhimnathwala H, Abrams MT, Davide JP, Ellis MS, Gibbs JB, Greenberg I, Koblan KS, Kral AM, Liu D, Lobell RB, Miller PJ, Mosser SD, O'Neill TJ, Rands E, Schaber MD, Senderak ET, Oliff A, Kohl NE.

Cancer Res. 2000 May 15;60(10):2680-8.

PMID:
10825141
[PubMed - indexed for MEDLINE]
Free Article
19.

Treatment with farnesyl-protein transferase inhibitor induces regression of mammary tumors in transforming growth factor (TGF) alpha and TGF alpha/neu transgenic mice by inhibition of mitogenic activity and induction of apoptosis.

Nørgaard P, Law B, Joseph H, Page DL, Shyr Y, Mays D, Pietenpol JA, Kohl NE, Oliff A, Coffey RJ Jr, Poulsen HS, Moses HL.

Clin Cancer Res. 1999 Jan;5(1):35-42.

PMID:
9918200
[PubMed - indexed for MEDLINE]
Free Article
20.

A peptidomimetic inhibitor of farnesyl:protein transferase blocks the anchorage-dependent and -independent growth of human tumor cell lines.

Sepp-Lorenzino L, Ma Z, Rands E, Kohl NE, Gibbs JB, Oliff A, Rosen N.

Cancer Res. 1995 Nov 15;55(22):5302-9.

PMID:
7585592
[PubMed - indexed for MEDLINE]
Free Article

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