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Results: 1 to 20 of 150

1.

Structural consequences of a cancer-causing BRCA1-BRCT missense mutation.

Williams RS, Glover JN.

J Biol Chem. 2003 Jan 24;278(4):2630-5. Epub 2002 Nov 8.

PMID:
12427738
[PubMed - indexed for MEDLINE]
Free Article
2.

Detection of protein folding defects caused by BRCA1-BRCT truncation and missense mutations.

Williams RS, Chasman DI, Hau DD, Hui B, Lau AY, Glover JN.

J Biol Chem. 2003 Dec 26;278(52):53007-16. Epub 2003 Oct 8.

PMID:
14534301
[PubMed - indexed for MEDLINE]
Free Article
3.

Thermal denaturation of the BRCT tandem repeat region of human tumour suppressor gene product BRCA1.

Pyrpassopoulos S, Ladopoulou A, Vlassi M, Papanikolau Y, Vorgias CE, Yannoukakos D, Nounesis G.

Biophys Chem. 2005 Apr 1;114(1):1-12. Epub 2004 Nov 5.

PMID:
15792855
[PubMed - indexed for MEDLINE]
4.

Crystal structure of the BRCT repeat region from the breast cancer-associated protein BRCA1.

Williams RS, Green R, Glover JN.

Nat Struct Biol. 2001 Oct;8(10):838-42.

PMID:
11573086
[PubMed - indexed for MEDLINE]
5.

Structural basis of phosphopeptide recognition by the BRCT domain of BRCA1.

Williams RS, Lee MS, Hau DD, Glover JN.

Nat Struct Mol Biol. 2004 Jun;11(6):519-25. Epub 2004 May 9.

PMID:
15133503
[PubMed - indexed for MEDLINE]
6.

Characterization of cancer-linked BRCA1-BRCT missense variants and their interaction with phosphoprotein targets.

Drikos I, Nounesis G, Vorgias CE.

Proteins. 2009 Nov 1;77(2):464-76. doi: 10.1002/prot.22460.

PMID:
19452558
[PubMed - indexed for MEDLINE]
7.

Structure of the BRCT repeats of BRCA1 bound to a BACH1 phosphopeptide: implications for signaling.

Shiozaki EN, Gu L, Yan N, Shi Y.

Mol Cell. 2004 May 7;14(3):405-12.

PMID:
15125843
[PubMed - indexed for MEDLINE]
8.

Cancer-related mutations in BRCA1-BRCT cause long-range structural changes in protein-protein binding sites: a molecular dynamics study.

Gough CA, Gojobori T, Imanishi T.

Proteins. 2007 Jan 1;66(1):69-86.

PMID:
17063491
[PubMed - indexed for MEDLINE]
9.

Missense mutations of BRCA1 gene affect the binding with p53 both in vitro and in vivo.

Quaresima B, Faniello MC, Baudi F, Crugliano T, Di Sanzo M, Cuda G, Costanzo F, Venuta S.

Oncol Rep. 2006 Oct;16(4):811-5.

PMID:
16969499
[PubMed - indexed for MEDLINE]
10.

Characterisation of the BRCT domains of the breast cancer susceptibility gene product BRCA1.

Ekblad CM, Wilkinson HR, Schymkowitz JW, Rousseau F, Freund SM, Itzhaki LS.

J Mol Biol. 2002 Jul 12;320(3):431-42.

PMID:
12096901
[PubMed - indexed for MEDLINE]
11.

Thermal unfolding of human BRCA1 BRCT-domain variants.

Nikolopoulos G, Pyrpassopoulos S, Thanassoulas A, Klimentzou P, Zikos C, Vlassi M, Vorgias CE, Yannoukakos D, Nounesis G.

Biochim Biophys Acta. 2007 Jun;1774(6):772-80. Epub 2007 Apr 6.

PMID:
17493881
[PubMed - indexed for MEDLINE]
12.

Solution structure, backbone dynamics, and association behavior of the C-terminal BRCT domain from the breast cancer-associated protein BRCA1.

Gaiser OJ, Ball LJ, Schmieder P, Leitner D, Strauss H, Wahl M, Kühne R, Oschkinat H, Heinemann U.

Biochemistry. 2004 Dec 28;43(51):15983-95.

PMID:
15609993
[PubMed - indexed for MEDLINE]
13.

Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer.

Clapperton JA, Manke IA, Lowery DM, Ho T, Haire LF, Yaffe MB, Smerdon SJ.

Nat Struct Mol Biol. 2004 Jun;11(6):512-8. Epub 2004 May 9.

PMID:
15133502
[PubMed - indexed for MEDLINE]
14.

The BRCA1 C-terminal domain: structure and function.

Huyton T, Bates PA, Zhang X, Sternberg MJ, Freemont PS.

Mutat Res. 2000 Aug 30;460(3-4):319-32.

PMID:
10946236
[PubMed - indexed for MEDLINE]
15.

Missense mutations in the BRCT domain of BRCA-1 from high-risk women frequently perturb strongly hydrophobic amino acids conserved among mammals.

Figge MA, Blankenship L.

Cancer Epidemiol Biomarkers Prev. 2004 Jun;13(6):1037-41.

PMID:
15184261
[PubMed - indexed for MEDLINE]
Free Article
16.

Functional assay for BRCA1: mutagenesis of the COOH-terminal region reveals critical residues for transcription activation.

Hayes F, Cayanan C, Barillà D, Monteiro AN.

Cancer Res. 2000 May 1;60(9):2411-8.

PMID:
10811118
[PubMed - indexed for MEDLINE]
Free Article
17.

Structural basis for cell cycle checkpoint control by the BRCA1-CtIP complex.

Varma AK, Brown RS, Birrane G, Ladias JA.

Biochemistry. 2005 Aug 23;44(33):10941-6.

PMID:
16101277
[PubMed - indexed for MEDLINE]
18.

Thermal and chemical denaturation of the BRCT functional module of human 53BP1.

Thanassoulas A, Nomikos M, Theodoridou M, Stavros P, Mastellos D, Nounesis G.

Int J Biol Macromol. 2011 Oct 1;49(3):297-304. doi: 10.1016/j.ijbiomac.2011.05.001. Epub 2011 May 11.

PMID:
21600917
[PubMed - indexed for MEDLINE]
19.

Comparison of BRCT domains of BRCA1 and 53BP1: a biophysical analysis.

Ekblad CM, Friedler A, Veprintsev D, Weinberg RL, Itzhaki LS.

Protein Sci. 2004 Mar;13(3):617-25.

PMID:
14978302
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

BRCT domain interactions in the heterodimeric DNA repair protein XRCC1-DNA ligase III.

Dulic A, Bates PA, Zhang X, Martin SR, Freemont PS, Lindahl T, Barnes DE.

Biochemistry. 2001 May 22;40(20):5906-13.

PMID:
11352725
[PubMed - indexed for MEDLINE]
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