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Results: 1 to 20 of 161

1.

The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility.

Liu Y, Fallon L, Lashuel HA, Liu Z, Lansbury PT Jr.

Cell. 2002 Oct 18;111(2):209-18.

PMID:
12408865
[PubMed - indexed for MEDLINE]
2.

UCH-L1 aggresome formation in response to proteasome impairment indicates a role in inclusion formation in Parkinson's disease.

Ardley HC, Scott GB, Rose SA, Tan NG, Robinson PA.

J Neurochem. 2004 Jul;90(2):379-91.

PMID:
15228595
[PubMed - indexed for MEDLINE]
3.

Expression of alpha-synuclein, parkin, and ubiquitin carboxy-terminal hydrolase L1 mRNA in human brain: genes associated with familial Parkinson's disease.

Solano SM, Miller DW, Augood SJ, Young AB, Penney JB Jr.

Ann Neurol. 2000 Feb;47(2):201-10.

PMID:
10665491
[PubMed - indexed for MEDLINE]
4.

Alterations of structure and hydrolase activity of parkinsonism-associated human ubiquitin carboxyl-terminal hydrolase L1 variants.

Nishikawa K, Li H, Kawamura R, Osaka H, Wang YL, Hara Y, Hirokawa T, Manago Y, Amano T, Noda M, Aoki S, Wada K.

Biochem Biophys Res Commun. 2003 Apr 25;304(1):176-83.

PMID:
12705903
[PubMed - indexed for MEDLINE]
5.

Effects of UCH-L1 on alpha-synuclein over-expression mouse model of Parkinson's disease.

Yasuda T, Nihira T, Ren YR, Cao XQ, Wada K, Setsuie R, Kabuta T, Wada K, Hattori N, Mizuno Y, Mochizuki H.

J Neurochem. 2009 Feb;108(4):932-44. doi: 10.1111/j.1471-4159.2008.05827.x. Epub 2009 Jan 7.

PMID:
19141079
[PubMed - indexed for MEDLINE]
6.

The cast of molecular characters in Parkinson's disease: felons, conspirators, and suspects.

Lim KL, Dawson VL, Dawson TM.

Ann N Y Acad Sci. 2003 Jun;991:80-92. Review.

PMID:
12846976
[PubMed - indexed for MEDLINE]
7.

Pathological proteins in Parkinson's disease: focus on the proteasome.

Snyder H, Wolozin B.

J Mol Neurosci. 2004;24(3):425-42. Review.

PMID:
15655264
[PubMed - indexed for MEDLINE]
8.

Genetics of Parkinson's disease and biochemical studies of implicated gene products.

Lansbury PT Jr, Brice A.

Curr Opin Cell Biol. 2002 Oct;14(5):653-60. Review.

PMID:
12231362
[PubMed - indexed for MEDLINE]
9.

Membrane-associated farnesylated UCH-L1 promotes alpha-synuclein neurotoxicity and is a therapeutic target for Parkinson's disease.

Liu Z, Meray RK, Grammatopoulos TN, Fredenburg RA, Cookson MR, Liu Y, Logan T, Lansbury PT Jr.

Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4635-40. doi: 10.1073/pnas.0806474106. Epub 2009 Mar 4.

PMID:
19261853
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Complex interactions in Parkinson's disease: a two-phased approach.

Maraganore DM, de Andrade M, Lesnick TG, Farrer MJ, Bower JH, Hardy JA, Rocca WA.

Mov Disord. 2003 Jun;18(6):631-6.

PMID:
12784265
[PubMed - indexed for MEDLINE]
11.

The ubiquitin carboxy-terminal hydrolase-L1 gene S18Y polymorphism does not confer protection against idiopathic Parkinson's disease.

Mellick GD, Silburn PA.

Neurosci Lett. 2000 Oct 27;293(2):127-30.

PMID:
11027850
[PubMed - indexed for MEDLINE]
12.

Is there a cause-and-effect relationship between alpha-synuclein fibrillization and Parkinson's disease?

Goldberg MS, Lansbury PT Jr.

Nat Cell Biol. 2000 Jul;2(7):E115-9.

PMID:
10878819
[PubMed - indexed for MEDLINE]
13.

Genetics of Parkinson's disease and biochemical studies of implicated gene products.

Lansbury PT Jr, Brice A.

Curr Opin Genet Dev. 2002 Jun;12(3):299-306. Review.

PMID:
12076673
[PubMed - indexed for MEDLINE]
14.

The Ile93Met mutation in the ubiquitin carboxy-terminal-hydrolase-L1 gene is not observed in European cases with familial Parkinson's disease.

Harhangi BS, Farrer MJ, Lincoln S, Bonifati V, Meco G, De Michele G, Brice A, Dürr A, Martinez M, Gasser T, Bereznai B, Vaughan JR, Wood NW, Hardy J, Oostra BA, Breteler MM.

Neurosci Lett. 1999 Jul 23;270(1):1-4.

PMID:
10454131
[PubMed - indexed for MEDLINE]
15.

Importance of familial Parkinson's disease and parkinsonism to the understanding of nigral degeneration in sporadic Parkinson's disease.

Hattori N, Shimura H, Kubo S, Wang M, Shimizu N, Tanaka K, Mizuno Y.

J Neural Transm Suppl. 2000;(60):101-16. Review.

PMID:
11205133
[PubMed - indexed for MEDLINE]
17.

Genetics of Parkinson's disease.

Gasser T.

J Neurol. 2001 Oct;248(10):833-40. Review.

PMID:
11697518
[PubMed - indexed for MEDLINE]
18.

Genetics of Parkinson's disease.

Polymeropoulos MH.

Ann N Y Acad Sci. 2000;920:28-32. Review.

PMID:
11193165
[PubMed - indexed for MEDLINE]
19.

S18Y in ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) associated with decreased risk of Parkinson's disease in Sweden.

Carmine Belin A, Westerlund M, Bergman O, Nissbrandt H, Lind C, Sydow O, Galter D.

Parkinsonism Relat Disord. 2007 Jul;13(5):295-8. Epub 2007 Feb 6.

PMID:
17287139
[PubMed - indexed for MEDLINE]
20.

Linkage exclusion in French families with probable Parkinson' s disease.

Farrer M, Destée T, Becquet E, Wavrant-De Vrièze F, Mouroux V, Richard F, Defebvre L, Lincoln S, Hardy J, Amouyel P, Chartier-Harlin MC.

Mov Disord. 2000 Nov;15(6):1075-83.

PMID:
11104189
[PubMed - indexed for MEDLINE]

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