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Liver-derived insulin-like growth factor-I is involved in the regulation of blood pressure in mice.

Tivesten A, Bollano E, Andersson I, Fitzgerald S, Caidahl K, Sjögren K, Skøtt O, Liu JL, Mobini R, Isaksson OG, Jansson JO, Ohlsson C, Bergström G, Isgaard J.

Endocrinology. 2002 Nov;143(11):4235-42.


Growth hormone receptor deficiency in mice results in reduced systolic blood pressure and plasma renin, increased aortic eNOS expression, and altered cardiovascular structure and function.

Egecioglu E, Andersson IJ, Bollano E, Palsdottir V, Gabrielsson BG, Kopchick JJ, Skott O, Bie P, Isgaard J, Bohlooly-Y M, Bergström G, Wickman A.

Am J Physiol Endocrinol Metab. 2007 May;292(5):E1418-25. Epub 2007 Jan 23.


Liver-derived IGF-I regulates kidney size, sodium reabsorption, and renal IGF-II expression.

Svensson J, Tivesten A, Sjögren K, Isaksson O, Bergström G, Mohan S, Mölne J, Isgaard J, Ohlsson C.

J Endocrinol. 2007 Jun;193(3):359-66.


Lack of endothelial nitric oxide synthase promotes endothelin-induced hypertension: lessons from endothelin-1 transgenic/endothelial nitric oxide synthase knockout mice.

Quaschning T, Voss F, Relle K, Kalk P, Vignon-Zellweger N, Pfab T, Bauer C, Theilig F, Bachmann S, Kraemer-Guth A, Wanner C, Theuring F, Galle J, Hocher B.

J Am Soc Nephrol. 2007 Mar;18(3):730-40. Epub 2007 Feb 7.


Investigation of vascular responses in endothelial nitric oxide synthase/cyclooxygenase-1 double-knockout mice: key role for endothelium-derived hyperpolarizing factor in the regulation of blood pressure in vivo.

Scotland RS, Madhani M, Chauhan S, Moncada S, Andresen J, Nilsson H, Hobbs AJ, Ahluwalia A.

Circulation. 2005 Feb 15;111(6):796-803. Epub 2005 Feb 7.


Busulphan-cyclophosphamide cause endothelial injury, remodeling of resistance arteries and enhanced expression of endothelial nitric oxide synthase.

Al-Hashmi S, Boels PJ, Zadjali F, Sadeghi B, Sällström J, Hultenby K, Hassan Z, Arner A, Hassan M.

PLoS One. 2012;7(1):e30897. doi: 10.1371/journal.pone.0030897. Epub 2012 Jan 27.


Acetylcholine-induced relaxation in blood vessels from endothelial nitric oxide synthase knockout mice.

Chataigneau T, Félétou M, Huang PL, Fishman MC, Duhault J, Vanhoutte PM.

Br J Pharmacol. 1999 Jan;126(1):219-26.


Endothelial dysfunction and arterial pressure regulation during early diabetes in mice: roles for nitric oxide and endothelium-derived hyperpolarizing factor.

Fitzgerald SM, Kemp-Harper BK, Parkington HC, Head GA, Evans RG.

Am J Physiol Regul Integr Comp Physiol. 2007 Aug;293(2):R707-13. Epub 2007 May 23.


Acetylcholine-induced relaxation of peripheral arteries isolated from mice lacking endothelial nitric oxide synthase.

Waldron GJ, Ding H, Lovren F, Kubes P, Triggle CR.

Br J Pharmacol. 1999 Oct;128(3):653-8.


Age-dependent onset of liver-specific IGF-I gene deficiency and its persistence in old age: implications for postnatal growth and insulin resistance in LID mice.

Tang Z, Yu R, Lu Y, Parlow AF, Liu JL.

Am J Physiol Endocrinol Metab. 2005 Aug;289(2):E288-95. Epub 2005 Mar 15.


Deletion of inducible nitric oxide synthase decreases mesenteric vascular responsiveness in portal hypertensive mice.

Bexis S, Vandeputte C, McCormick PA, Docherty JR.

Eur J Pharmacol. 2004 Sep 24;499(3):325-33.


Short-term insulin treatment and aortic expressions of IGF-1 receptor and VEGF mRNA in diabetic rats.

Kobayashi T, Kamata K.

Am J Physiol Heart Circ Physiol. 2002 Nov;283(5):H1761-8.


Endothelium-specific GTP cyclohydrolase I overexpression attenuates blood pressure progression in salt-sensitive low-renin hypertension.

Du YH, Guan YY, Alp NJ, Channon KM, Chen AF.

Circulation. 2008 Feb 26;117(8):1045-54. doi: 10.1161/CIRCULATIONAHA.107.748236. Epub 2008 Feb 11.


Liver-derived IGF-I is permissive for ovariectomy-induced trabecular bone loss.

Lindberg MK, Svensson J, Venken K, Chavoshi T, Andersson N, Movérare Skrtic S, Isaksson O, Vanderschueren D, Carlsten H, Ohlsson C.

Bone. 2006 Jan;38(1):85-92. Epub 2005 Oct 27.


Influence of type II diabetes on arterial tone and endothelial function in murine mesenteric resistance arteries.

Lagaud GJ, Masih-Khan E, Kai S, van Breemen C, Dubé GP.

J Vasc Res. 2001 Nov-Dec;38(6):578-89.


The inhibition of inducible nitric oxide synthase reverts arthritic-induced decrease in pituitary growth hormone mRNA but not in liver insulin-like growth factor I mRNA expression.

Ibáñez de Cáceres I, Priego T, Martín AI, López-Calderón A, Villanúa MA.

J Neuroendocrinol. 2003 Dec;15(12):1178-84.


Age-dependent impairment of endothelial progenitor cells is corrected by growth-hormone-mediated increase of insulin-like growth-factor-1.

Thum T, Hoeber S, Froese S, Klink I, Stichtenoth DO, Galuppo P, Jakob M, Tsikas D, Anker SD, Poole-Wilson PA, Borlak J, Ertl G, Bauersachs J.

Circ Res. 2007 Feb 16;100(3):434-43. Epub 2007 Jan 18.

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