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Pleiotropic defects in TCR signaling in a Vav-1-null Jurkat T-cell line.

Cao Y, Janssen EM, Duncan AW, Altman A, Billadeau DD, Abraham RT.

EMBO J. 2002 Sep 16;21(18):4809-19.


Vav2 activates c-fos serum response element and CD69 expression but negatively regulates nuclear factor of activated T cells and interleukin-2 gene activation in T lymphocyte.

Tartare-Deckert S, Monthouel MN, Charvet C, Foucault I, Van Obberghen E, Bernard A, Altman A, Deckert M.

J Biol Chem. 2001 Jun 15;276(24):20849-57. Epub 2001 Mar 21.


A functional T-cell receptor signaling pathway is required for p95vav activity.

Wu J, Katzav S, Weiss A.

Mol Cell Biol. 1995 Aug;15(8):4337-46.


Tyrosine phosphorylation of adaptor protein 3BP2 induces T cell receptor-mediated activation of transcription factor.

Qu X, Kawauchi-Kamata K, Miah SM, Hatani T, Yamamura H, Sada K.

Biochemistry. 2005 Mar 15;44(10):3891-8.


Vav-induced activation of the human IFN-gamma gene promoter is mediated by upregulation of AP-1 activity.

Kaminuma O, Elly C, Tanaka Y, Mori A, Liu YC, Altman A, Miyatake S.

FEBS Lett. 2002 Mar 13;514(2-3):153-8.


Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction.

Holsinger LJ, Graef IA, Swat W, Chi T, Bautista DM, Davidson L, Lewis RS, Alt FW, Crabtree GR.

Curr Biol. 1998 May 7;8(10):563-72.


Tyrosine phosphorylation of Vav stimulates IL-6 production in mast cells by a Rac/c-Jun N-terminal kinase-dependent pathway.

Song JS, Haleem-Smith H, Arudchandran R, Gomez J, Scott PM, Mill JF, Tan TH, Rivera J.

J Immunol. 1999 Jul 15;163(2):802-10.


Vav1/2/3-null mice define an essential role for Vav family proteins in lymphocyte development and activation but a differential requirement in MAPK signaling in T and B cells.

Fujikawa K, Miletic AV, Alt FW, Faccio R, Brown T, Hoog J, Fredericks J, Nishi S, Mildiner S, Moores SL, Brugge J, Rosen FS, Swat W.

J Exp Med. 2003 Nov 17;198(10):1595-608.


A novel functional interaction between Vav and PKCtheta is required for TCR-induced T cell activation.

Villalba M, Coudronniere N, Deckert M, Teixeiro E, Mas P, Altman A.

Immunity. 2000 Feb;12(2):151-60.


Vav synergizes with protein kinase C theta to mediate IL-4 gene expression in response to CD28 costimulation in T cells.

Hehner SP, Li-Weber M, Giaisi M, Dröge W, Krammer PH, Schmitz ML.

J Immunol. 2000 Apr 1;164(7):3829-36.


hSiah2 is a new Vav binding protein which inhibits Vav-mediated signaling pathways.

Germani A, Romero F, Houlard M, Camonis J, Gisselbrecht S, Fischer S, Varin-Blank N.

Mol Cell Biol. 1999 May;19(5):3798-807.


Vav family proteins couple to diverse cell surface receptors.

Moores SL, Selfors LM, Fredericks J, Breit T, Fujikawa K, Alt FW, Brugge JS, Swat W.

Mol Cell Biol. 2000 Sep;20(17):6364-73.


Rac-1 dependent stimulation of the JNK/SAPK signaling pathway by Vav.

Crespo P, Bustelo XR, Aaronson DS, Coso OA, Lopez-Barahona M, Barbacid M, Gutkind JS.

Oncogene. 1996 Aug 1;13(3):455-60.


Specific subdomains of Vav differentially affect T cell and NK cell activation.

Billadeau DD, Mackie SM, Schoon RA, Leibson PJ.

J Immunol. 2000 Apr 15;164(8):3971-81.

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