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The Nek2 protein kinase: a novel regulator of centrosome structure.

Fry AM.

Oncogene. 2002 Sep 9;21(40):6184-94. Review.


Nek5 promotes centrosome integrity in interphase and loss of centrosome cohesion in mitosis.

Prosser SL, Sahota NK, Pelletier L, Morrison CG, Fry AM.

J Cell Biol. 2015 May 11;209(3):339-48. doi: 10.1083/jcb.201412099.


The centrosome: a prospective entrant in cancer therapy.

Venghateri JB, Jindal B, Panda D.

Expert Opin Ther Targets. 2015 Jul;19(7):957-72. doi: 10.1517/14728222.2015.1018823. Epub 2015 Mar 18.


A novel bipartite centrosome coordinates the apicomplexan cell cycle.

Suvorova ES, Francia M, Striepen B, White MW.

PLoS Biol. 2015 Mar 3;13(3):e1002093. doi: 10.1371/journal.pbio.1002093. eCollection 2015 Mar.


Cep68 can be regulated by Nek2 and SCF complex.

Man X, Megraw TL, Lim YP.

Eur J Cell Biol. 2015 Mar-Apr;94(3-4):162-72. doi: 10.1016/j.ejcb.2015.01.004. Epub 2015 Feb 4.


Nek2 is a novel regulator of B cell development and immunological response.

Gu Z, Zhou W, Huang J, Yang Y, Wendlandt E, Xu H, He X, Tricot G, Zhan F.

Biomed Res Int. 2014;2014:621082. doi: 10.1155/2014/621082. Epub 2014 Nov 17.


Inhibition of Nek2 by small molecules affects proteasome activity.

Meng L, Carpenter K, Mollard A, Vankayalapati H, Warner SL, Sharma S, Tricot G, Zhan F, Bearss DJ.

Biomed Res Int. 2014;2014:273180. doi: 10.1155/2014/273180. Epub 2014 Sep 17.


Centriolar satellites: key mediators of centrosome functions.

Tollenaere MA, Mailand N, Bekker-Jensen S.

Cell Mol Life Sci. 2015 Jan;72(1):11-23. doi: 10.1007/s00018-014-1711-3. Epub 2014 Aug 31. Review.


The role of mitotic kinases in coupling the centrosome cycle with the assembly of the mitotic spindle.

Wang G, Jiang Q, Zhang C.

J Cell Sci. 2014 Oct 1;127(Pt 19):4111-22. doi: 10.1242/jcs.151753. Epub 2014 Aug 15.


Cell Cycle Regulation of the Centrosome and Cilium.

Avidor-Reiss T, Gopalakrishnan J.

Drug Discov Today Dis Mech. 2013 Dec 1;10(3-4):e119-e124.


The centriolar protein Bld10/Cep135 is required to establish centrosome asymmetry in Drosophila neuroblasts.

Singh P, Ramdas Nair A, Cabernard C.

Curr Biol. 2014 Jul 7;24(13):1548-55. doi: 10.1016/j.cub.2014.05.050. Epub 2014 Jun 19.


"Stop Ne(c)king around": How interactomics contributes to functionally characterize Nek family kinases.

Meirelles GV, Perez AM, de Souza EE, Basei FL, Papa PF, Melo Hanchuk TD, Cardoso VB, Kobarg J.

World J Biol Chem. 2014 May 26;5(2):141-60. doi: 10.4331/wjbc.v5.i2.141. Review.


E2F activators signal and maintain centrosome amplification in breast cancer cells.

Lee MY, Moreno CS, Saavedra HI.

Mol Cell Biol. 2014 Jul;34(14):2581-99.


Multisite phosphorylation of C-Nap1 releases it from Cep135 to trigger centrosome disjunction.

Hardy T, Lee M, Hames RS, Prosser SL, Cheary DM, Samant MD, Schultz F, Baxter JE, Rhee K, Fry AM.

J Cell Sci. 2014 Jun 1;127(Pt 11):2493-506. doi: 10.1242/jcs.142331. Epub 2014 Apr 2.


Novel small molecules disrupting Hec1/Nek2 interaction ablate tumor progression by triggering Nek2 degradation through a death-trap mechanism.

Hu CM, Zhu J, Guo XE, Chen W, Qiu XL, Ngo B, Chien R, Wang YV, Tsai CY, Wu G, Kim Y, Lopez R, Chamberlin AR, Lee EY, Lee WH.

Oncogene. 2015 Mar 5;34(10):1220-30. doi: 10.1038/onc.2014.67. Epub 2014 Mar 24.


Therapeutic melting pot of never in mitosis gene a related kinase 2 (Nek2): a perspective on Nek2 as an oncology target and recent advancements in Nek2 small molecule inhibition.

Frett B, Brown RV, Ma M, Hu W, Han H, Li HY.

J Med Chem. 2014 Jul 24;57(14):5835-44. doi: 10.1021/jm401719n. Epub 2014 Feb 25. Review.


Nek2 phosphorylates and stabilizes β-catenin at mitotic centrosomes downstream of Plk1.

Mbom BC, Siemers KA, Ostrowski MA, Nelson WJ, Barth AI.

Mol Biol Cell. 2014 Apr;25(7):977-91. doi: 10.1091/mbc.E13-06-0349. Epub 2014 Feb 5.


Nek2 and Plk4: prognostic markers, drivers of breast tumorigenesis and drug resistance.

Marina M, Saavedra HI.

Front Biosci (Landmark Ed). 2014 Jan 1;19:352-65. Review.


The centrosomal kinase NEK2 is a novel splicing factor kinase involved in cell survival.

Naro C, Barbagallo F, Chieffi P, Bourgeois CF, Paronetto MP, Sette C.

Nucleic Acids Res. 2014 Mar;42(5):3218-27. doi: 10.1093/nar/gkt1307. Epub 2013 Dec 24.


Nup62: a novel regulator of centrosome integrity and function.

Borlido J, D'Angelo MA.

Cell Cycle. 2014;13(1):14. doi: 10.4161/cc.27299. Epub 2013 Nov 22. No abstract available.

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