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Items: 1 to 20 of 172


PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin.

Steiner H, Winkler E, Edbauer D, Prokop S, Basset G, Yamasaki A, Kostka M, Haass C.

J Biol Chem. 2002 Oct 18;277(42):39062-5. Epub 2002 Aug 26.


Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation.

Edbauer D, Winkler E, Haass C, Steiner H.

Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8666-71. Epub 2002 Jun 4.


Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the gamma-secretase complex.

Prokop S, Shirotani K, Edbauer D, Haass C, Steiner H.

J Biol Chem. 2004 May 28;279(22):23255-61. Epub 2004 Mar 23.


Presenilin modulates Pen-2 levels posttranslationally by protecting it from proteasomal degradation.

Crystal AS, Morais VA, Fortna RR, Carlin D, Pierson TC, Wilson CA, Lee VM, Doms RW.

Biochemistry. 2004 Mar 30;43(12):3555-63.


Characterization of the reconstituted gamma-secretase complex from Sf9 cells co-expressing presenilin 1, nicastrin [correction of nacastrin], aph-1a, and pen-2.

Zhang L, Lee J, Song L, Sun X, Shen J, Terracina G, Parker EM.

Biochemistry. 2005 Mar 22;44(11):4450-7.


gamma-Secretase complexes containing N- and C-terminal fragments of different presenilin origin retain normal gamma-secretase activity.

Strömberg K, Hansson EM, Laudon H, Bergstedt S, Näslund J, Lundkvist J, Lendahl U.

J Neurochem. 2005 Nov;95(3):880-90. Epub 2005 Aug 31.


Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase complexes in mitochondria.

Hansson CA, Frykman S, Farmery MR, Tjernberg LO, Nilsberth C, Pursglove SE, Ito A, Winblad B, Cowburn RF, Thyberg J, Ankarcrona M.

J Biol Chem. 2004 Dec 3;279(49):51654-60. Epub 2004 Sep 28.


Gamma-secretase activity is associated with a conformational change of nicastrin.

Shirotani K, Edbauer D, Capell A, Schmitz J, Steiner H, Haass C.

J Biol Chem. 2003 May 9;278(19):16474-7. Epub 2003 Mar 18.


The transmembrane domain region of nicastrin mediates direct interactions with APH-1 and the gamma-secretase complex.

Morais VA, Crystal AS, Pijak DS, Carlin D, Costa J, Lee VM, Doms RW.

J Biol Chem. 2003 Oct 31;278(44):43284-91. Epub 2003 Aug 12.


PEN-2 enhances gamma-cleavage after presenilin heterodimer formation.

Shiraishi H, Sai X, Wang HQ, Maeda Y, Kurono Y, Nishimura M, Yanagisawa K, Komano H.

J Neurochem. 2004 Sep;90(6):1402-13.


Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components.

Zhang YW, Luo WJ, Wang H, Lin P, Vetrivel KS, Liao F, Li F, Wong PC, Farquhar MG, Thinakaran G, Xu H.

J Biol Chem. 2005 Apr 29;280(17):17020-6. Epub 2005 Feb 11.


Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex.

Fraering PC, LaVoie MJ, Ye W, Ostaszewski BL, Kimberly WT, Selkoe DJ, Wolfe MS.

Biochemistry. 2004 Jan 20;43(2):323-33.


Transition-state analogue gamma-secretase inhibitors stabilize a 900 kDa presenilin/nicastrin complex.

Evin G, Canterford LD, Hoke DE, Sharples RA, Culvenor JG, Masters CL.

Biochemistry. 2005 Mar 22;44(11):4332-41.


Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane.

Kaether C, Lammich S, Edbauer D, Ertl M, Rietdorf J, Capell A, Steiner H, Haass C.

J Cell Biol. 2002 Aug 5;158(3):551-61. Epub 2002 Jul 29.


Nicastrin interacts with gamma-secretase complex components via the N-terminal part of its transmembrane domain.

Capell A, Kaether C, Edbauer D, Shirotani K, Merkl S, Steiner H, Haass C.

J Biol Chem. 2003 Dec 26;278(52):52519-23. Epub 2003 Nov 5.


Pen-2 is incorporated into the gamma-secretase complex through binding to transmembrane domain 4 of presenilin 1.

Watanabe N, Tomita T, Sato C, Kitamura T, Morohashi Y, Iwatsubo T.

J Biol Chem. 2005 Dec 23;280(51):41967-75. Epub 2005 Oct 18.


Positive and negative regulation of the gamma-secretase activity by nicastrin in a murine model.

Li J, Fici GJ, Mao CA, Myers RL, Shuang R, Donoho GP, Pauley AM, Himes CS, Qin W, Kola I, Merchant KM, Nye JS.

J Biol Chem. 2003 Aug 29;278(35):33445-9. Epub 2003 Jun 18.

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