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Results: 1 to 20 of 468

1.

A comparison of the receptor binding and HERG channel affinities for a series of antipsychotic drugs.

Kongsamut S, Kang J, Chen XL, Roehr J, Rampe D.

Eur J Pharmacol. 2002 Aug 16;450(1):37-41.

PMID:
12176106
[PubMed - indexed for MEDLINE]
2.

The antipsychotic agent sertindole is a high affinity antagonist of the human cardiac potassium channel HERG.

Rampe D, Murawsky MK, Grau J, Lewis EW.

J Pharmacol Exp Ther. 1998 Aug;286(2):788-93.

PMID:
9694935
[PubMed - indexed for MEDLINE]
Free Article
3.

Interactions of a series of fluoroquinolone antibacterial drugs with the human cardiac K+ channel HERG.

Kang J, Wang L, Chen XL, Triggle DJ, Rampe D.

Mol Pharmacol. 2001 Jan;59(1):122-6.

PMID:
11125032
[PubMed - indexed for MEDLINE]
Free Article
4.

High affinity blockade of the HERG cardiac K(+) channel by the neuroleptic pimozide.

Kang J, Wang L, Cai F, Rampe D.

Eur J Pharmacol. 2000 Mar 31;392(3):137-40.

PMID:
10762666
[PubMed - indexed for MEDLINE]
5.

Interactions of the 5-hydroxytryptamine 3 antagonist class of antiemetic drugs with human cardiac ion channels.

Kuryshev YA, Brown AM, Wang L, Benedict CR, Rampe D.

J Pharmacol Exp Ther. 2000 Nov;295(2):614-20.

PMID:
11046096
[PubMed - indexed for MEDLINE]
Free Article
6.

The inhibitory effect of the antipsychotic drug haloperidol on HERG potassium channels expressed in Xenopus oocytes.

Suessbrich H, Schönherr R, Heinemann SH, Attali B, Lang F, Busch AE.

Br J Pharmacol. 1997 Mar;120(5):968-74.

PMID:
9138706
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Blockade of human cardiac potassium channel human ether-a-go-go-related gene (HERG) by macrolide antibiotics.

Volberg WA, Koci BJ, Su W, Lin J, Zhou J.

J Pharmacol Exp Ther. 2002 Jul;302(1):320-7.

PMID:
12065733
[PubMed - indexed for MEDLINE]
Free Article
8.

The antipsychotic drugs sertindole and pimozide block erg3, a human brain K(+) channel.

Kang J, Chen XL, Rampe D.

Biochem Biophys Res Commun. 2001 Aug 24;286(3):499-504.

PMID:
11511086
[PubMed - indexed for MEDLINE]
9.

The binding site for channel blockers that rescue misprocessed human long QT syndrome type 2 ether-a-gogo-related gene (HERG) mutations.

Ficker E, Obejero-Paz CA, Zhao S, Brown AM.

J Biol Chem. 2002 Feb 15;277(7):4989-98. Epub 2001 Dec 10.

PMID:
11741928
[PubMed - indexed for MEDLINE]
Free Article
10.

Familial and acquired long qt syndrome and the cardiac rapid delayed rectifier potassium current.

Witchel HJ, Hancox JC.

Clin Exp Pharmacol Physiol. 2000 Oct;27(10):753-66. Review.

PMID:
11022966
[PubMed - indexed for MEDLINE]
11.

Interactions of the antimalarial drug mefloquine with the human cardiac potassium channels KvLQT1/minK and HERG.

Kang J, Chen XL, Wang L, Rampe D.

J Pharmacol Exp Ther. 2001 Oct;299(1):290-6.

PMID:
11561091
[PubMed - indexed for MEDLINE]
Free Article
12.

A mechanism for the proarrhythmic effects of cisapride (Propulsid): high affinity blockade of the human cardiac potassium channel HERG.

Rampe D, Roy ML, Dennis A, Brown AM.

FEBS Lett. 1997 Nov 3;417(1):28-32.

PMID:
9395068
[PubMed - indexed for MEDLINE]
Free Article
13.

Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development.

Redfern WS, Carlsson L, Davis AS, Lynch WG, MacKenzie I, Palethorpe S, Siegl PK, Strang I, Sullivan AT, Wallis R, Camm AJ, Hammond TG.

Cardiovasc Res. 2003 Apr 1;58(1):32-45. Review.

PMID:
12667944
[PubMed - indexed for MEDLINE]
Free Article
14.

Blockage of the HERG human cardiac K+ channel by the gastrointestinal prokinetic agent cisapride.

Mohammad S, Zhou Z, Gong Q, January CT.

Am J Physiol. 1997 Nov;273(5 Pt 2):H2534-8.

PMID:
9374794
[PubMed - indexed for MEDLINE]
Free Article
15.

The anti-malarial drug halofantrine and its metabolite N-desbutylhalofantrine block HERG potassium channels.

Mbai M, Rajamani S, January CT.

Cardiovasc Res. 2002 Sep;55(4):799-805.

PMID:
12176129
[PubMed - indexed for MEDLINE]
Free Article
16.

Drug binding to aromatic residues in the HERG channel pore cavity as possible explanation for acquired Long QT syndrome by antiparkinsonian drug budipine.

Scholz EP, Zitron E, Kiesecker C, Lueck S, Kathöfer S, Thomas D, Weretka S, Peth S, Kreye VA, Schoels W, Katus HA, Kiehn J, Karle CA.

Naunyn Schmiedebergs Arch Pharmacol. 2003 Nov;368(5):404-14. Epub 2003 Oct 14.

PMID:
14557918
[PubMed - indexed for MEDLINE]
17.

Comparative evaluation of hERG potassium channel blockade by antipsychotics.

Silvestre JS, Prous JR.

Methods Find Exp Clin Pharmacol. 2007 Sep;29(7):457-65.

PMID:
17982510
[PubMed - indexed for MEDLINE]
18.

Inhibition of cloned HERG potassium channels by the antiestrogen tamoxifen.

Thomas D, Gut B, Karsai S, Wimmer AB, Wu K, Wendt-Nordahl G, Zhang W, Kathöfer S, Schoels W, Katus HA, Kiehn J, Karle CA.

Naunyn Schmiedebergs Arch Pharmacol. 2003 Jul;368(1):41-8. Epub 2003 Jun 25.

PMID:
12827215
[PubMed - indexed for MEDLINE]
19.

Automated electrophysiology in the preclinical evaluation of drugs for potential QT prolongation.

Guo L, Guthrie H.

J Pharmacol Toxicol Methods. 2005 Jul-Aug;52(1):123-35.

PMID:
15936217
[PubMed - indexed for MEDLINE]
20.

Inhibition of HERG potassium channel current by the class 1a antiarrhythmic agent disopyramide.

Paul AA, Witchel HJ, Hancox JC.

Biochem Biophys Res Commun. 2001 Feb 9;280(5):1243-50.

PMID:
11162661
[PubMed - indexed for MEDLINE]
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