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Items: 1 to 20 of 89

1.

Akt regulates growth by directly phosphorylating Tsc2.

Potter CJ, Pedraza LG, Xu T.

Nat Cell Biol. 2002 Sep;4(9):658-65.

PMID:
12172554
2.

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling.

Inoki K, Li Y, Zhu T, Wu J, Guan KL.

Nat Cell Biol. 2002 Sep;4(9):648-57.

PMID:
12172553
3.

Tsc2 is not a critical target of Akt during normal Drosophila development.

Dong J, Pan D.

Genes Dev. 2004 Oct 15;18(20):2479-84. Epub 2004 Oct 1.

4.
5.

Regulation of TSC2 by 14-3-3 binding.

Li Y, Inoki K, Yeung R, Guan KL.

J Biol Chem. 2002 Nov 22;277(47):44593-6. Epub 2002 Oct 2.

6.

Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin.

Dan HC, Sun M, Yang L, Feldman RI, Sui XM, Ou CC, Nellist M, Yeung RS, Halley DJ, Nicosia SV, Pledger WJ, Cheng JQ.

J Biol Chem. 2002 Sep 20;277(38):35364-70. Epub 2002 Jul 11.

7.

Tumour suppressors hamartin and tuberin: intracellular signalling.

Krymskaya VP.

Cell Signal. 2003 Aug;15(8):729-39. Review.

PMID:
12781866
8.

TSC1-TSC2: a complex tale of PKB-mediated S6K regulation.

McManus EJ, Alessi DR.

Nat Cell Biol. 2002 Sep;4(9):E214-6. No abstract available.

PMID:
12205484
9.

Akt phosphorylates both Tsc1 and Tsc2 in Drosophila, but neither phosphorylation is required for normal animal growth.

Schleich S, Teleman AA.

PLoS One. 2009 Jul 17;4(7):e6305. doi: 10.1371/journal.pone.0006305.

10.

Signaling from Akt to FRAP/TOR targets both 4E-BP and S6K in Drosophila melanogaster.

Miron M, Lasko P, Sonenberg N.

Mol Cell Biol. 2003 Dec;23(24):9117-26.

11.

Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR.

Zhang H, Cicchetti G, Onda H, Koon HB, Asrican K, Bajraszewski N, Vazquez F, Carpenter CL, Kwiatkowski DJ.

J Clin Invest. 2003 Oct;112(8):1223-33.

12.

The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3.

Li Y, Inoki K, Vacratsis P, Guan KL.

J Biol Chem. 2003 Apr 18;278(16):13663-71. Epub 2003 Feb 11.

13.

Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase.

Roux PP, Ballif BA, Anjum R, Gygi SP, Blenis J.

Proc Natl Acad Sci U S A. 2004 Sep 14;101(37):13489-94. Epub 2004 Sep 1.

14.

The mTOR/S6K signalling pathway: the role of the TSC1/2 tumour suppressor complex and the proto-oncogene Rheb.

Nobukini T, Thomas G.

Novartis Found Symp. 2004;262:148-54; discussion 154-9, 265-8. Review.

PMID:
15562827
15.

Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling.

Gao X, Zhang Y, Arrazola P, Hino O, Kobayashi T, Yeung RS, Ru B, Pan D.

Nat Cell Biol. 2002 Sep;4(9):699-704.

PMID:
12172555
16.

Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity.

Hahn-Windgassen A, Nogueira V, Chen CC, Skeen JE, Sonenberg N, Hay N.

J Biol Chem. 2005 Sep 16;280(37):32081-9. Epub 2005 Jul 15.

17.

A complex interplay between Akt, TSC2 and the two mTOR complexes.

Huang J, Manning BD.

Biochem Soc Trans. 2009 Feb;37(Pt 1):217-22. doi: 10.1042/BST0370217. Review.

18.

Phosphorylation of insulin receptor substrate-1 (IRS-1) by protein kinase B positively regulates IRS-1 function.

Paz K, Liu YF, Shorer H, Hemi R, LeRoith D, Quan M, Kanety H, Seger R, Zick Y.

J Biol Chem. 1999 Oct 1;274(40):28816-22.

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20.

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.

Sarbassov DD, Guertin DA, Ali SM, Sabatini DM.

Science. 2005 Feb 18;307(5712):1098-101.

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