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Items: 1 to 20 of 88

1.

A RIP tide in neuronal signal transduction.

Ebinu JO, Yankner BA.

Neuron. 2002 May 16;34(4):499-502. Review.

2.

gamma-Secretase cleavage and binding to FE65 regulate the nuclear translocation of the intracellular C-terminal domain (ICD) of the APP family of proteins.

Walsh DM, Fadeeva JV, LaVoie MJ, Paliga K, Eggert S, Kimberly WT, Wasco W, Selkoe DJ.

Biochemistry. 2003 Jun 10;42(22):6664-73.

PMID:
12779321
3.

Familial Alzheimer's disease mutations inhibit gamma-secretase-mediated liberation of beta-amyloid precursor protein carboxy-terminal fragment.

Wiley JC, Hudson M, Kanning KC, Schecterson LC, Bothwell M.

J Neurochem. 2005 Sep;94(5):1189-201. Epub 2005 Jun 30.

5.

Got RIP? Presenilin-dependent intramembrane proteolysis in growth factor receptor signaling.

Landman N, Kim TW.

Cytokine Growth Factor Rev. 2004 Oct;15(5):337-51. Review.

PMID:
15450250
6.

APP intracellular domain formation and unaltered signaling in the presence of familial Alzheimer's disease mutations.

Bergman A, Religa D, Karlström H, Laudon H, Winblad B, Lannfelt L, Lundkvist J, Näslund J.

Exp Cell Res. 2003 Jul 1;287(1):1-9.

PMID:
12799176
7.
9.

Palmitoylation of the C-terminal fragment of p75(NTR) regulates death signaling and is required for subsequent cleavage by gamma-secretase.

Underwood CK, Reid K, May LM, Bartlett PF, Coulson EJ.

Mol Cell Neurosci. 2008 Feb;37(2):346-58. Epub 2007 Oct 23.

PMID:
18055214
10.
11.

Embryonic stem cell-derived neurons as a cellular system to study gene function: lack of amyloid precursor proteins APP and APLP2 leads to defective synaptic transmission.

Schrenk-Siemens K, Perez-Alcala S, Richter J, Lacroix E, Rahuel J, Korte M, Müller U, Barde YA, Bibel M.

Stem Cells. 2008 Aug;26(8):2153-63. doi: 10.1634/stemcells.2008-0010. Epub 2008 Jun 5.

12.

Ectodomain shedding and intramembrane cleavage of mammalian Notch proteins is not regulated through oligomerization.

Vooijs M, Schroeter EH, Pan Y, Blandford M, Kopan R.

J Biol Chem. 2004 Dec 3;279(49):50864-73. Epub 2004 Sep 23.

13.
14.

Fe65 stimulates proteolytic liberation of the beta-amyloid precursor protein intracellular domain.

Wiley JC, Smith EA, Hudson MP, Ladiges WC, Bothwell M.

J Biol Chem. 2007 Nov 16;282(46):33313-25. Epub 2007 Sep 11.

15.

Notch1 competes with the amyloid precursor protein for gamma-secretase and down-regulates presenilin-1 gene expression.

Lleó A, Berezovska O, Ramdya P, Fukumoto H, Raju S, Shah T, Hyman BT.

J Biol Chem. 2003 Nov 28;278(48):47370-5. Epub 2003 Sep 5.

16.

Regulated intramembrane proteolysis of the p75 neurotrophin receptor modulates its association with the TrkA receptor.

Jung KM, Tan S, Landman N, Petrova K, Murray S, Lewis R, Kim PK, Kim DS, Ryu SH, Chao MV, Kim TW.

J Biol Chem. 2003 Oct 24;278(43):42161-9. Epub 2003 Aug 11.

17.

Release of a membrane-bound death domain by gamma-secretase processing of the p75NTR homolog NRADD.

Gowrishankar K, Zeidler MG, Vincenz C.

J Cell Sci. 2004 Aug 15;117(Pt 18):4099-111. Epub 2004 Jul 27.

19.

The insulin-like growth factor 1 (IGF-1) receptor is a substrate for gamma-secretase-mediated intramembrane proteolysis.

McElroy B, Powell JC, McCarthy JV.

Biochem Biophys Res Commun. 2007 Jul 13;358(4):1136-41. Epub 2007 May 21.

PMID:
17524361
20.

Endocytosis-independent mechanisms of Delta ligand proteolysis.

Delwig A, Bland C, Beem-Miller M, Kimberly P, Rand MD.

Exp Cell Res. 2006 May 1;312(8):1345-60. Epub 2006 Feb 17.

PMID:
16487968
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