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Items: 1 to 20 of 107


Chk2 activation and phosphorylation-dependent oligomerization.

Xu X, Tsvetkov LM, Stern DF.

Mol Cell Biol. 2002 Jun;22(12):4419-32.


Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro.

Matsuoka S, Rotman G, Ogawa A, Shiloh Y, Tamai K, Elledge SJ.

Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10389-94.


MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways.

Lou Z, Minter-Dykhouse K, Wu X, Chen J.

Nature. 2003 Feb 27;421(6926):957-61.


Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchange.

Oliver AW, Paul A, Boxall KJ, Barrie SE, Aherne GW, Garrett MD, Mittnacht S, Pearl LH.

EMBO J. 2006 Jul 12;25(13):3179-90. Epub 2006 Jun 22.


Priming phosphorylation of Chk2 by polo-like kinase 3 (Plk3) mediates its full activation by ATM and a downstream checkpoint in response to DNA damage.

Bahassi el M, Myer DL, McKenney RJ, Hennigan RF, Stambrook PJ.

Mutat Res. 2006 Apr 11;596(1-2):166-76. Epub 2006 Feb 14.


Biochemical and cellular characterization of VRX0466617, a novel and selective inhibitor for the checkpoint kinase Chk2.

Carlessi L, Buscemi G, Larson G, Hong Z, Wu JZ, Delia D.

Mol Cancer Ther. 2007 Mar;6(3):935-44.


Structural and functional versatility of the FHA domain in DNA-damage signaling by the tumor suppressor kinase Chk2.

Li J, Williams BL, Haire LF, Goldberg M, Wilker E, Durocher D, Yaffe MB, Jackson SP, Smerdon SJ.

Mol Cell. 2002 May;9(5):1045-54.


Regulation of CHK2 by DNA-dependent protein kinase.

Li J, Stern DF.

J Biol Chem. 2005 Mar 25;280(12):12041-50. Epub 2005 Jan 24.


Structure and activation mechanism of the CHK2 DNA damage checkpoint kinase.

Cai Z, Chehab NH, Pavletich NP.

Mol Cell. 2009 Sep 24;35(6):818-29. doi: 10.1016/j.molcel.2009.09.007.


Suppression of Tousled-like kinase activity after DNA damage or replication block requires ATM, NBS1 and Chk1.

Krause DR, Jonnalagadda JC, Gatei MH, Sillje HH, Zhou BB, Nigg EA, Khanna K.

Oncogene. 2003 Sep 4;22(38):5927-37.


Chk2 oligomerization studied by phosphopeptide ligation: implications for regulation and phosphodependent interactions.

Li J, Taylor IA, Lloyd J, Clapperton JA, Howell S, MacMillan D, Smerdon SJ.

J Biol Chem. 2008 Dec 19;283(51):36019-30. doi: 10.1074/jbc.M804075200. Epub 2008 Oct 23.


Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway.

Chaturvedi P, Eng WK, Zhu Y, Mattern MR, Mishra R, Hurle MR, Zhang X, Annan RS, Lu Q, Faucette LF, Scott GF, Li X, Carr SA, Johnson RK, Winkler JD, Zhou BB.

Oncogene. 1999 Jul 15;18(28):4047-54.


Exploring the intramolecular phosphorylation sites in human Chk2.

Olsen BB, Larsen MR, Boldyreff B, Niefind K, Issinger OG.

Mutat Res. 2008 Nov 10;646(1-2):50-9. doi: 10.1016/j.mrfmmm.2008.09.002. Epub 2008 Sep 11.


Differential roles for checkpoint kinases in DNA damage-dependent degradation of the Cdc25A protein phosphatase.

Jin J, Ang XL, Ye X, Livingstone M, Harper JW.

J Biol Chem. 2008 Jul 11;283(28):19322-8. doi: 10.1074/jbc.M802474200. Epub 2008 May 13.


DNA damage regulates Chk2 association with chromatin.

Li J, Stern DF.

J Biol Chem. 2005 Nov 11;280(45):37948-56. Epub 2005 Sep 8.


Chk2 activation dependence on Nbs1 after DNA damage.

Buscemi G, Savio C, Zannini L, Miccichè F, Masnada D, Nakanishi M, Tauchi H, Komatsu K, Mizutani S, Khanna K, Chen P, Concannon P, Chessa L, Delia D.

Mol Cell Biol. 2001 Aug;21(15):5214-22.


Characterization of tumor-associated Chk2 mutations.

Wu X, Webster SR, Chen J.

J Biol Chem. 2001 Jan 26;276(4):2971-4. Epub 2000 Oct 26.

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