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Items: 1 to 20 of 95

1.

P2Y(2) receptor agonists: a new class of medication targeted at improved mucociliary clearance.

Kellerman DJ.

Chest. 2002 May;121(5 Suppl):201S-205S. Review.

PMID:
12010852
2.

Inhaled P2Y2 receptor agonists as a treatment for patients with Cystic Fibrosis lung disease.

Kellerman D, Evans R, Mathews D, Shaffer C.

Adv Drug Deliv Rev. 2002 Dec 5;54(11):1463-74. Review.

PMID:
12458155
3.

Aerosolization of P2Y(2)-receptor agonists enhances mucociliary clearance in sheep.

Sabater JR, Mao YM, Shaffer C, James MK, O'Riordan TG, Abraham WM.

J Appl Physiol (1985). 1999 Dec;87(6):2191-6.

4.

Pharmacology of INS37217 [P(1)-(uridine 5')-P(4)- (2'-deoxycytidine 5')tetraphosphate, tetrasodium salt], a next-generation P2Y(2) receptor agonist for the treatment of cystic fibrosis.

Yerxa BR, Sabater JR, Davis CW, Stutts MJ, Lang-Furr M, Picher M, Jones AC, Cowlen M, Dougherty R, Boyer J, Abraham WM, Boucher RC.

J Pharmacol Exp Ther. 2002 Sep;302(3):871-80.

5.

Denufosol: a review of studies with inhaled P2Y(2) agonists that led to Phase 3.

Kellerman D, Rossi Mospan A, Engels J, Schaberg A, Gorden J, Smiley L.

Pulm Pharmacol Ther. 2008 Aug;21(4):600-7. doi: 10.1016/j.pupt.2007.12.003. Epub 2007 Dec 31. Review.

PMID:
18276176
6.
7.

Synthesis and potency of novel uracil nucleotides and derivatives as P2Y2 and P2Y6 receptor agonists.

Ko H, Carter RL, Cosyn L, Petrelli R, de Castro S, Besada P, Zhou Y, Cappellacci L, Franchetti P, Grifantini M, Van Calenbergh S, Harden TK, Jacobson KA.

Bioorg Med Chem. 2008 Jun 15;16(12):6319-32. doi: 10.1016/j.bmc.2008.05.013. Epub 2008 May 9.

8.
9.

Secretion of ATP from Schwann cells in response to uridine triphosphate.

Liu GJ, Werry EL, Bennett MR.

Eur J Neurosci. 2005 Jan;21(1):151-60.

PMID:
15654852
10.

Safety of aerosolized INS 365 in patients with mild to moderate cystic fibrosis: results of a phase I multi-center study.

Noone PG, Hamblett N, Accurso F, Aitken ML, Boyle M, Dovey M, Gibson R, Johnson C, Kellerman D, Konstan MW, Milgram L, Mundahl J, Retsch-Bogort G, Rodman D, Williams-Warren J, Wilmott RW, Zeitlin P, Ramsey B; Cystic Fibrosis Therapeutics Development Research Group.

Pediatr Pulmonol. 2001 Aug;32(2):122-8.

PMID:
11477729
11.

Diquafosol elicits increases in net Cl- transport through P2Y2 receptor stimulation in rabbit conjunctiva.

Murakami T, Fujihara T, Horibe Y, Nakamura M.

Ophthalmic Res. 2004 Mar-Apr;36(2):89-93.

PMID:
15017104
12.
13.

Effect of uridine 5'-triphosphate plus amiloride on mucociliary clearance in adult cystic fibrosis.

Bennett WD, Olivier KN, Zeman KL, Hohneker KW, Boucher RC, Knowles MR.

Am J Respir Crit Care Med. 1996 Jun;153(6 Pt 1):1796-801.

PMID:
8665037
14.

The medicinal chemistry of the P2 receptor family.

Guile SD, Ince F, Ingall AH, Kindon ND, Meghani P, Mortimore MP.

Prog Med Chem. 2001;38:115-87. Review. No abstract available.

PMID:
11774794
15.

Potency and duration of action of synthetic P2Y2 receptor agonists on Schirmer scores in rabbits.

Yerxa BR, Douglass JG, Elena PP, Caillaud T, Amar T, Edick C, Peterson WM.

Adv Exp Med Biol. 2002;506(Pt A):261-5. No abstract available.

PMID:
12613918
16.
17.

P2 receptors activated by uracil nucleotides--an update.

Brunschweiger A, Müller CE.

Curr Med Chem. 2006;13(3):289-312. Review.

PMID:
16475938
18.

Acute safety and effects on mucociliary clearance of aerosolized uridine 5'-triphosphate +/- amiloride in normal human adults.

Olivier KN, Bennett WD, Hohneker KW, Zeman KL, Edwards LJ, Boucher RC, Knowles MR.

Am J Respir Crit Care Med. 1996 Jul;154(1):217-23.

PMID:
8680683
19.

Effect of aerosolized uridine 5'-triphosphate on mucociliary clearance in mild chronic bronchitis.

Bennett WD, Zeman KL, Foy C, Shaffer CL, Johnson FL, Regnis JA, Sannuti A, Johnson J.

Am J Respir Crit Care Med. 2001 Jul 15;164(2):302-6.

PMID:
11463605
20.

Selective P2Y2 receptor agonists stimulate vaginal moisture in ovariectomized rabbits.

Min K, Munarriz R, Yerxa BR, Goldstein I, Shaver SR, Cowlen MS, Traish AM.

Fertil Steril. 2003 Feb;79(2):393-8.

PMID:
12568851
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