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Results: 1 to 20 of 157

1.

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo.

Walsh DM, Klyubin I, Fadeeva JV, Cullen WK, Anwyl R, Wolfe MS, Rowan MJ, Selkoe DJ.

Nature. 2002 Apr 4;416(6880):535-9.

PMID:
11932745
[PubMed - indexed for MEDLINE]
2.

Certain inhibitors of synthetic amyloid beta-peptide (Abeta) fibrillogenesis block oligomerization of natural Abeta and thereby rescue long-term potentiation.

Walsh DM, Townsend M, Podlisny MB, Shankar GM, Fadeeva JV, El Agnaf O, Hartley DM, Selkoe DJ.

J Neurosci. 2005 Mar 9;25(10):2455-62. Erratum in: J Neurosci. 2005 May 4;25(18):4658.

PMID:
15758153
[PubMed - indexed for MEDLINE]
Free Article
3.

Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo.

Klyubin I, Walsh DM, Lemere CA, Cullen WK, Shankar GM, Betts V, Spooner ET, Jiang L, Anwyl R, Selkoe DJ, Rowan MJ.

Nat Med. 2005 May;11(5):556-61. Epub 2005 Apr 17.

PMID:
15834427
[PubMed - indexed for MEDLINE]
4.

Neuronal deficiency of presenilin 1 inhibits amyloid plaque formation and corrects hippocampal long-term potentiation but not a cognitive defect of amyloid precursor protein [V717I] transgenic mice.

Dewachter I, Reversé D, Caluwaerts N, Ris L, Kuipéri C, Van den Haute C, Spittaels K, Umans L, Serneels L, Thiry E, Moechars D, Mercken M, Godaux E, Van Leuven F.

J Neurosci. 2002 May 1;22(9):3445-53.

PMID:
11978821
[PubMed - indexed for MEDLINE]
Free Article
5.

Dynamics of {beta}-amyloid reductions in brain, cerebrospinal fluid, and plasma of {beta}-amyloid precursor protein transgenic mice treated with a {gamma}-secretase inhibitor.

Barten DM, Guss VL, Corsa JA, Loo A, Hansel SB, Zheng M, Munoz B, Srinivasan K, Wang B, Robertson BJ, Polson CT, Wang J, Roberts SB, Hendrick JP, Anderson JJ, Loy JK, Denton R, Verdoorn TA, Smith DW, Felsenstein KM.

J Pharmacol Exp Ther. 2005 Feb;312(2):635-43. Epub 2004 Sep 27.

PMID:
15452193
[PubMed - indexed for MEDLINE]
Free Article
6.

Beta-amyloid peptide in regulated secretory vesicles of chromaffin cells: evidence for multiple cysteine proteolytic activities in distinct pathways for beta-secretase activity in chromaffin vesicles.

Hook VY, Toneff T, Aaron W, Yasothornsrikul S, Bundey R, Reisine T.

J Neurochem. 2002 Apr;81(2):237-56.

PMID:
12064471
[PubMed - indexed for MEDLINE]
7.

The role of cell-derived oligomers of Abeta in Alzheimer's disease and avenues for therapeutic intervention.

Walsh DM, Klyubin I, Shankar GM, Townsend M, Fadeeva JV, Betts V, Podlisny MB, Cleary JP, Ashe KH, Rowan MJ, Selkoe DJ.

Biochem Soc Trans. 2005 Nov;33(Pt 5):1087-90. Review.

PMID:
16246051
[PubMed - indexed for MEDLINE]
8.

Protein kinase C mediates amyloid beta-protein fragment 31-35-induced suppression of hippocampal late-phase long-term potentiation in vivo.

Zhang JF, Qi JS, Qiao JT.

Neurobiol Learn Mem. 2009 Mar;91(3):226-34. doi: 10.1016/j.nlm.2008.11.004. Epub 2008 Dec 23.

PMID:
19061963
[PubMed - indexed for MEDLINE]
9.

Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation.

Qiu WQ, Walsh DM, Ye Z, Vekrellis K, Zhang J, Podlisny MB, Rosner MR, Safavi A, Hersh LB, Selkoe DJ.

J Biol Chem. 1998 Dec 4;273(49):32730-8.

PMID:
9830016
[PubMed - indexed for MEDLINE]
Free Article
10.

Human beta-secretase (BACE) and BACE inhibitors: progress report.

John V.

Curr Top Med Chem. 2006;6(6):569-78. Review.

PMID:
16712492
[PubMed - indexed for MEDLINE]
11.

The oligomerization of amyloid beta-protein begins intracellularly in cells derived from human brain.

Walsh DM, Tseng BP, Rydel RE, Podlisny MB, Selkoe DJ.

Biochemistry. 2000 Sep 5;39(35):10831-9.

PMID:
10978169
[PubMed - indexed for MEDLINE]
12.

NMDA receptor regulation by amyloid-beta does not account for its inhibition of LTP in rat hippocampus.

Raymond CR, Ireland DR, Abraham WC.

Brain Res. 2003 Apr 11;968(2):263-72.

PMID:
12663096
[PubMed - indexed for MEDLINE]
13.

Globular amyloid beta-peptide oligomer - a homogenous and stable neuropathological protein in Alzheimer's disease.

Barghorn S, Nimmrich V, Striebinger A, Krantz C, Keller P, Janson B, Bahr M, Schmidt M, Bitner RS, Harlan J, Barlow E, Ebert U, Hillen H.

J Neurochem. 2005 Nov;95(3):834-47. Epub 2005 Aug 31.

PMID:
16135089
[PubMed - indexed for MEDLINE]
14.

Insulin rescues amyloid beta-induced impairment of hippocampal long-term potentiation.

Lee CC, Kuo YM, Huang CC, Hsu KS.

Neurobiol Aging. 2009 Mar;30(3):377-87. Epub 2007 Aug 10.

PMID:
17692997
[PubMed - indexed for MEDLINE]
15.

In vivo assessment of brain interstitial fluid with microdialysis reveals plaque-associated changes in amyloid-beta metabolism and half-life.

Cirrito JR, May PC, O'Dell MA, Taylor JW, Parsadanian M, Cramer JW, Audia JE, Nissen JS, Bales KR, Paul SM, DeMattos RB, Holtzman DM.

J Neurosci. 2003 Oct 1;23(26):8844-53.

PMID:
14523085
[PubMed - indexed for MEDLINE]
Free Article
16.

beta-Secretase, APP and Abeta in Alzheimer's disease.

Vassar R.

Subcell Biochem. 2005;38:79-103. Review.

PMID:
15709474
[PubMed - indexed for MEDLINE]
17.

Orally available compound prevents deficits in memory caused by the Alzheimer amyloid-beta oligomers.

Townsend M, Cleary JP, Mehta T, Hofmeister J, Lesne S, O'Hare E, Walsh DM, Selkoe DJ.

Ann Neurol. 2006 Dec;60(6):668-76.

PMID:
17192927
[PubMed - indexed for MEDLINE]
18.

Reductions in beta-amyloid concentrations in vivo by the gamma-secretase inhibitors BMS-289948 and BMS-299897.

Anderson JJ, Holtz G, Baskin PP, Turner M, Rowe B, Wang B, Kounnas MZ, Lamb BT, Barten D, Felsenstein K, McDonald I, Srinivasan K, Munoz B, Wagner SL.

Biochem Pharmacol. 2005 Feb 15;69(4):689-98. Epub 2005 Jan 7.

PMID:
15670587
[PubMed - indexed for MEDLINE]
19.

Oral treatment with a gamma-secretase inhibitor improves long-term potentiation in a mouse model of Alzheimer's disease.

Townsend M, Qu Y, Gray A, Wu Z, Seto T, Hutton M, Shearman MS, Middleton RE.

J Pharmacol Exp Ther. 2010 Apr;333(1):110-9. doi: 10.1124/jpet.109.163691. Epub 2010 Jan 7.

PMID:
20056779
[PubMed - indexed for MEDLINE]
Free Article
20.

Reducing amyloid plaque burden via ex vivo gene delivery of an Abeta-degrading protease: a novel therapeutic approach to Alzheimer disease.

Hemming ML, Patterson M, Reske-Nielsen C, Lin L, Isacson O, Selkoe DJ.

PLoS Med. 2007 Aug;4(8):e262.

PMID:
17760499
[PubMed - indexed for MEDLINE]
Free PMC Article

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