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Results: 1 to 20 of 109

1.

Expression of simian immunodeficiency virus nef in immune cells of transgenic mice leads to a severe AIDS-like disease.

Simard MC, Chrobak P, Kay DG, Hanna Z, Jothy S, Jolicoeur P.

J Virol. 2002 Apr;76(8):3981-95.

PMID:
11907238
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Activation of p21-activated kinase 2 and its association with Nef are conserved in murine cells but are not sufficient to induce an AIDS-like disease in CD4C/HIV transgenic mice.

Vincent P, Priceputu E, Kay D, Saksela K, Jolicoeur P, Hanna Z.

J Biol Chem. 2006 Mar 17;281(11):6940-54. Epub 2005 Dec 28.

PMID:
16407193
[PubMed - indexed for MEDLINE]
Free Article
4.

Primary human immunodeficiency virus type 1 nef alleles show major differences in pathogenicity in transgenic mice.

Priceputu E, Hanna Z, Hu C, Simard MC, Vincent P, Wildum S, Schindler M, Kirchhoff F, Jolicoeur P.

J Virol. 2007 May;81(9):4677-93. Epub 2007 Feb 21.

PMID:
17314161
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

HIV-1 Nef mutations abrogating downregulation of CD4 affect other Nef functions and show reduced pathogenicity in transgenic mice.

Hanna Z, Priceputu E, Hu C, Vincent P, Jolicoeur P.

Virology. 2006 Mar 1;346(1):40-52. Epub 2005 Nov 28.

PMID:
16310238
[PubMed - indexed for MEDLINE]
Free Article
6.

Adult AIDS-like disease in a novel inducible human immunodeficiency virus type 1 Nef transgenic mouse model: CD4+ T-cell activation is Nef dependent and can occur in the absence of lymphophenia.

Rahim MM, Chrobak P, Hu C, Hanna Z, Jolicoeur P.

J Virol. 2009 Nov;83(22):11830-46. doi: 10.1128/JVI.01466-09. Epub 2009 Sep 9.

PMID:
19740990
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

CD4+ T cells from CD4C/HIVNef transgenic mice show enhanced activation in vivo with impaired proliferation in vitro but are dispensable for the development of a severe AIDS-like organ disease.

Weng X, Priceputu E, Chrobak P, Poudrier J, Kay DG, Hanna Z, Mak TW, Jolicoeur P.

J Virol. 2004 May;78(10):5244-57.

PMID:
15113906
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Immunization of macaques with live simian human immunodeficiency virus (SHIV) vaccines conferred protection against AIDS induced by homologous and heterologous SHIVs and simian immunodeficiency virus.

Kumar A, Mukherjee S, Shen J, Buch S, Li Z, Adany I, Liu Z, Zhuge W, Piatak M Jr, Lifson J, McClure H, Narayan O.

Virology. 2002 Sep 30;301(2):189-205.

PMID:
12359422
[PubMed - indexed for MEDLINE]
Free Article
9.

Selective expression of human immunodeficiency virus Nef in specific immune cell populations of transgenic mice is associated with distinct AIDS-like phenotypes.

Hanna Z, Priceputu E, Chrobak P, Hu C, Dugas V, Goupil M, Marquis M, de Repentigny L, Jolicoeur P.

J Virol. 2009 Oct;83(19):9743-58. doi: 10.1128/JVI.00125-09. Epub 2009 Jul 15.

PMID:
19605470
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

SIV/HIV Nef recombinant virus (SHIVnef) produces simian AIDS in rhesus macaques.

Mandell CP, Reyes RA, Cho K, Sawai ET, Fang AL, Schmidt KA, Luciw PA.

Virology. 1999 Dec 20;265(2):235-51.

PMID:
10600596
[PubMed - indexed for MEDLINE]
Free Article
11.

In vivo mutational analysis of the N-terminal region of HIV-1 Nef reveals critical motifs for the development of an AIDS-like disease in CD4C/HIV transgenic mice.

Hanna Z, Priceputu E, Kay DG, Poudrier J, Chrobak P, Jolicoeur P.

Virology. 2004 Oct 1;327(2):273-86.

PMID:
15351215
[PubMed - indexed for MEDLINE]
Free Article
12.

Normal development and function but impaired memory phenotype of CD8⁺ T cells in transgenic mice expressing HIV-1 Nef in its natural target cells.

Ahmed Rahim MM, Chrobak P, Priceputu E, Hanna Z, Jolicoeur P.

Virology. 2013 Apr 10;438(2):84-97. doi: 10.1016/j.virol.2013.01.008. Epub 2013 Feb 22.

PMID:
23433958
[PubMed - indexed for MEDLINE]
Free Article
13.

Specific suppression of human CD4 surface expression by Nef from the pathogenic simian immunodeficiency virus SIVmac239open.

Foster JL, Anderson SJ, Frazier AL, Garcia JV.

Virology. 1994 Jun;201(2):373-9.

PMID:
8184546
[PubMed - indexed for MEDLINE]
14.

nef gene is required for robust productive infection by simian immunodeficiency virus of T-cell-rich paracortex in lymph nodes.

Sugimoto C, Tadakuma K, Otani I, Moritoyo T, Akari H, Ono F, Yoshikawa Y, Sata T, Izumo S, Mori K.

J Virol. 2003 Apr;77(7):4169-80.

PMID:
12634375
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Could Nef and Vpr proteins contribute to disease progression by promoting depletion of bystander cells and prolonged survival of HIV-infected cells?

Azad AA.

Biochem Biophys Res Commun. 2000 Jan 27;267(3):677-85. Review.

PMID:
10673351
[PubMed - indexed for MEDLINE]
16.

Immunodeficiency viruses. Not enough sans Nef.

Littman DR.

Curr Biol. 1994 Jul 1;4(7):618-20. Review.

PMID:
7953537
[PubMed - indexed for MEDLINE]
17.

Nef harbors a major determinant of pathogenicity for an AIDS-like disease induced by HIV-1 in transgenic mice.

Hanna Z, Kay DG, Rebai N, Guimond A, Jothy S, Jolicoeur P.

Cell. 1998 Oct 16;95(2):163-75.

PMID:
9790524
[PubMed - indexed for MEDLINE]
Free Article
18.

Chronology of genetic changes in the vpu, env, and Nef genes of chimeric simian-human immunodeficiency virus (strain HXB2) during acquisition of virulence for pig-tailed macaques.

McCormick-Davis C, Zhao LJ, Mukherjee S, Leung K, Sheffer D, Joag SV, Narayan O, Stephens EB.

Virology. 1998 Sep 1;248(2):275-83.

PMID:
9721236
[PubMed - indexed for MEDLINE]
Free Article
19.

Simian and human immunodeficiency virus Nef proteins use different surfaces to downregulate class I major histocompatibility complex antigen expression.

Swigut T, Iafrate AJ, Muench J, Kirchhoff F, Skowronski J.

J Virol. 2000 Jun;74(12):5691-701.

PMID:
10823877
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Expression of simian immunodeficiency virus (SIV) nef in astrocytes during acute and terminal infection and requirement of nef for optimal replication of neurovirulent SIV in vitro.

Overholser ED, Coleman GD, Bennett JL, Casaday RJ, Zink MC, Barber SA, Clements JE.

J Virol. 2003 Jun;77(12):6855-66.

PMID:
12768005
[PubMed - indexed for MEDLINE]
Free PMC Article

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