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Items: 1 to 20 of 85


Hypoxia links ATR and p53 through replication arrest.

Hammond EM, Denko NC, Dorie MJ, Abraham RT, Giaccia AJ.

Mol Cell Biol. 2002 Mar;22(6):1834-43.


Comparison of hypoxia-induced replication arrest with hydroxyurea and aphidicolin-induced arrest.

Hammond EM, Green SL, Giaccia AJ.

Mutat Res. 2003 Nov 27;532(1-2):205-13.


Hypoxia-inducible factor 1alpha is essential for cell cycle arrest during hypoxia.

Goda N, Ryan HE, Khadivi B, McNulty W, Rickert RC, Johnson RS.

Mol Cell Biol. 2003 Jan;23(1):359-69.


ATR controls cellular adaptation to hypoxia through positive regulation of hypoxia-inducible factor 1 (HIF-1) expression.

Fallone F, Britton S, Nieto L, Salles B, Muller C.

Oncogene. 2013 Sep 12;32(37):4387-96. doi: 10.1038/onc.2012.462. Epub 2012 Oct 22.


ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation.

Hammond EM, Dorie MJ, Giaccia AJ.

J Biol Chem. 2003 Apr 4;278(14):12207-13. Epub 2003 Jan 7.


S-phase sensing of DNA-protein crosslinks triggers TopBP1-independent ATR activation and p53-mediated cell death by formaldehyde.

Wong VC, Cash HL, Morse JL, Lu S, Zhitkovich A.

Cell Cycle. 2012 Jul 1;11(13):2526-37. doi: 10.4161/cc.20905. Epub 2012 Jul 1.


Inhibition of ATR leads to increased sensitivity to hypoxia/reoxygenation.

Hammond EM, Dorie MJ, Giaccia AJ.

Cancer Res. 2004 Sep 15;64(18):6556-62.


Dual regulation of Cdc25A by Chk1 and p53-ATF3 in DNA replication checkpoint control.

Demidova AR, Aau MY, Zhuang L, Yu Q.

J Biol Chem. 2009 Feb 13;284(7):4132-9. doi: 10.1074/jbc.M808118200. Epub 2008 Dec 7.


Functional role of Mdm2 phosphorylation by ATR in attenuation of p53 nuclear export.

Shinozaki T, Nota A, Taya Y, Okamoto K.

Oncogene. 2003 Dec 4;22(55):8870-80.


Targeting radiation-resistant hypoxic tumour cells through ATR inhibition.

Pires IM, Olcina MM, Anbalagan S, Pollard JR, Reaper PM, Charlton PA, McKenna WG, Hammond EM.

Br J Cancer. 2012 Jul 10;107(2):291-9. doi: 10.1038/bjc.2012.265. Epub 2012 Jun 19.


BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage.

Fabbro M, Savage K, Hobson K, Deans AJ, Powell SN, McArthur GA, Khanna KK.

J Biol Chem. 2004 Jul 23;279(30):31251-8. Epub 2004 May 24.


ATR is not required for p53 activation but synergizes with p53 in the replication checkpoint.

Nghiem P, Park PK, Kim Ys YS, Desai BN, Schreiber SL.

J Biol Chem. 2002 Feb 8;277(6):4428-34. Epub 2001 Nov 15.


UVC inhibits HIF-1alpha protein translation by a DNA damage- and topoisomerase I-independent pathway.

Rapisarda A, Melillo G.

Oncogene. 2007 Oct 18;26(48):6875-84. Epub 2007 May 14.


Hyperoxia activates the ATR-Chk1 pathway and phosphorylates p53 at multiple sites.

Das KC, Dashnamoorthy R.

Am J Physiol Lung Cell Mol Physiol. 2004 Jan;286(1):L87-97. Epub 2003 Sep 5.


DNA damage induced by temozolomide signals to both ATM and ATR: role of the mismatch repair system.

Caporali S, Falcinelli S, Starace G, Russo MT, Bonmassar E, Jiricny J, D'Atri S.

Mol Pharmacol. 2004 Sep;66(3):478-91.


ATM activation and signaling under hypoxic conditions.

Bencokova Z, Kaufmann MR, Pires IM, Lecane PS, Giaccia AJ, Hammond EM.

Mol Cell Biol. 2009 Jan;29(2):526-37. doi: 10.1128/MCB.01301-08. Epub 2008 Nov 3.


Cell cycle kinase inhibitor expression and hypoxia-induced cell cycle arrest in human cancer cell lines.

Box AH, Demetrick DJ.

Carcinogenesis. 2004 Dec;25(12):2325-35. Epub 2004 Sep 3.


Regulation of p53 by hypoxia: dissociation of transcriptional repression and apoptosis from p53-dependent transactivation.

Koumenis C, Alarcon R, Hammond E, Sutphin P, Hoffman W, Murphy M, Derr J, Taya Y, Lowe SW, Kastan M, Giaccia A.

Mol Cell Biol. 2001 Feb;21(4):1297-310.


Ataxia telangiectasia mutated (ATM) and ATM and Rad3-related protein exhibit selective target specificities in response to different forms of DNA damage.

Helt CE, Cliby WA, Keng PC, Bambara RA, O'Reilly MA.

J Biol Chem. 2005 Jan 14;280(2):1186-92. Epub 2004 Nov 8.

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