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Results: 1 to 20 of 103

1.

Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes.

Mauvais-Jarvis F, Ueki K, Fruman DA, Hirshman MF, Sakamoto K, Goodyear LJ, Iannacone M, Accili D, Cantley LC, Kahn CR.

J Clin Invest. 2002 Jan;109(1):141-9.

PMID:
11781359
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival.

Ueki K, Fruman DA, Brachmann SM, Tseng YH, Cantley LC, Kahn CR.

Mol Cell Biol. 2002 Feb;22(3):965-77.

PMID:
11784871
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Increased P85alpha is a potent negative regulator of skeletal muscle insulin signaling and induces in vivo insulin resistance associated with growth hormone excess.

Barbour LA, Mizanoor Rahman S, Gurevich I, Leitner JW, Fischer SJ, Roper MD, Knotts TA, Vo Y, McCurdy CE, Yakar S, Leroith D, Kahn CR, Cantley LC, Friedman JE, Draznin B.

J Biol Chem. 2005 Nov 11;280(45):37489-94. Epub 2005 Sep 8.

PMID:
16166093
[PubMed - indexed for MEDLINE]
Free Article
4.

Positive and negative roles of p85 alpha and p85 beta regulatory subunits of phosphoinositide 3-kinase in insulin signaling.

Ueki K, Fruman DA, Yballe CM, Fasshauer M, Klein J, Asano T, Cantley LC, Kahn CR.

J Biol Chem. 2003 Nov 28;278(48):48453-66. Epub 2003 Sep 22.

PMID:
14504291
[PubMed - indexed for MEDLINE]
Free Article
5.

Positive and negative regulation of phosphoinositide 3-kinase-dependent signaling pathways by three different gene products of the p85alpha regulatory subunit.

Ueki K, Algenstaedt P, Mauvais-Jarvis F, Kahn CR.

Mol Cell Biol. 2000 Nov;20(21):8035-46.

PMID:
11027274
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Decreased Akt kinase activity and insulin resistance in C57BL/KsJ-Leprdb/db mice.

Shao J, Yamashita H, Qiao L, Friedman JE.

J Endocrinol. 2000 Oct;167(1):107-15.

PMID:
11018758
[PubMed - indexed for MEDLINE]
Free Article
7.

Reduced glucose uptake precedes insulin signaling defects in adipocytes from heterozygous GLUT4 knockout mice.

Li J, Houseknecht KL, Stenbit AE, Katz EB, Charron MJ.

FASEB J. 2000 Jun;14(9):1117-25.

PMID:
10834933
[PubMed - indexed for MEDLINE]
Free Article
8.

Muscle fiber type-specific defects in insulin signal transduction to glucose transport in diabetic GK rats.

Song XM, Kawano Y, Krook A, Ryder JW, Efendic S, Roth RA, Wallberg-Henriksson H, Zierath JR.

Diabetes. 1999 Mar;48(3):664-70.

PMID:
10078575
[PubMed - indexed for MEDLINE]
Free Article
9.

Role of the liver in glucose homeostasis in PI 3-kinase p85alpha-deficient mice.

Aoki K, Matsui J, Kubota N, Nakajima H, Iwamoto K, Takamoto I, Tsuji Y, Ohno A, Mori S, Tokuyama K, Murakami K, Asano T, Aizawa S, Tobe K, Kadowaki T, Terauchi Y.

Am J Physiol Endocrinol Metab. 2009 Apr;296(4):E842-53. doi: 10.1152/ajpendo.90528.2008. Epub 2009 Jan 27.

PMID:
19176357
[PubMed - indexed for MEDLINE]
Free Article
10.

The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex.

Luo J, Field SJ, Lee JY, Engelman JA, Cantley LC.

J Cell Biol. 2005 Aug 1;170(3):455-64. Epub 2005 Jul 25.

PMID:
16043515
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

The p85alpha regulatory subunit of phosphoinositide 3-kinase potentiates c-Jun N-terminal kinase-mediated insulin resistance.

Taniguchi CM, Aleman JO, Ueki K, Luo J, Asano T, Kaneto H, Stephanopoulos G, Cantley LC, Kahn CR.

Mol Cell Biol. 2007 Apr;27(8):2830-40. Epub 2007 Feb 5.

PMID:
17283057
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Insulin signaling in insulin receptor substrate (IRS)-1-deficient brown adipocytes: requirement of IRS-1 for lipid synthesis.

Valverde AM, Kahn CR, Benito M.

Diabetes. 1999 Nov;48(11):2122-31.

PMID:
10535444
[PubMed - indexed for MEDLINE]
Free Article
13.

Phosphoinositide 3-kinase catalytic subunit deletion and regulatory subunit deletion have opposite effects on insulin sensitivity in mice.

Brachmann SM, Ueki K, Engelman JA, Kahn RC, Cantley LC.

Mol Cell Biol. 2005 Mar;25(5):1596-607.

PMID:
15713620
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Growth hormone regulation of p85alpha expression and phosphoinositide 3-kinase activity in adipose tissue: mechanism for growth hormone-mediated insulin resistance.

del Rincon JP, Iida K, Gaylinn BD, McCurdy CE, Leitner JW, Barbour LA, Kopchick JJ, Friedman JE, Draznin B, Thorner MO.

Diabetes. 2007 Jun;56(6):1638-46. Epub 2007 Mar 15.

PMID:
17363744
[PubMed - indexed for MEDLINE]
Free Article
15.

Effects of streptozocin diabetes and diabetes treatment by islet transplantation on in vivo insulin signaling in rat heart.

Laviola L, Belsanti G, Davalli AM, Napoli R, Perrini S, Weir GC, Giorgino R, Giorgino F.

Diabetes. 2001 Dec;50(12):2709-20.

PMID:
11723053
[PubMed - indexed for MEDLINE]
Free Article
16.

Altered signaling and cell cycle regulation in embryonal stem cells with a disruption of the gene for phosphoinositide 3-kinase regulatory subunit p85alpha.

Hallmann D, Trümper K, Trusheim H, Ueki K, Kahn CR, Cantley LC, Fruman DA, Hörsch D.

J Biol Chem. 2003 Feb 14;278(7):5099-108. Epub 2002 Nov 14.

PMID:
12435753
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Phosphoinositide 3-kinase regulatory subunit p85alpha suppresses insulin action via positive regulation of PTEN.

Taniguchi CM, Tran TT, Kondo T, Luo J, Ueki K, Cantley LC, Kahn CR.

Proc Natl Acad Sci U S A. 2006 Aug 8;103(32):12093-7. Epub 2006 Jul 31.

PMID:
16880400
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Growth hormone induces cellular insulin resistance by uncoupling phosphatidylinositol 3-kinase and its downstream signals in 3T3-L1 adipocytes.

Takano A, Haruta T, Iwata M, Usui I, Uno T, Kawahara J, Ueno E, Sasaoka T, Kobayashi M.

Diabetes. 2001 Aug;50(8):1891-900.

PMID:
11473053
[PubMed - indexed for MEDLINE]
Free Article
19.

Diversification of cardiac insulin signaling involves the p85 alpha/beta subunits of phosphatidylinositol 3-kinase.

Kessler A, Uphues I, Ouwens DM, Till M, Eckel J.

Am J Physiol Endocrinol Metab. 2001 Jan;280(1):E65-74.

PMID:
11120660
[PubMed - indexed for MEDLINE]
Free Article
20.

Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase.

Ueki K, Yballe CM, Brachmann SM, Vicent D, Watt JM, Kahn CR, Cantley LC.

Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):419-24. Epub 2001 Dec 18.

PMID:
11752399
[PubMed - indexed for MEDLINE]
Free PMC Article

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