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Shear stress stimulates phosphorylation of endothelial nitric-oxide synthase at Ser1179 by Akt-independent mechanisms: role of protein kinase A.

Boo YC, Sorescu G, Boyd N, Shiojima I, Walsh K, Du J, Jo H.

J Biol Chem. 2002 Feb 1;277(5):3388-96. Epub 2001 Nov 29.


Shear stress stimulates phosphorylation of eNOS at Ser(635) by a protein kinase A-dependent mechanism.

Boo YC, Hwang J, Sykes M, Michell BJ, Kemp BE, Lum H, Jo H.

Am J Physiol Heart Circ Physiol. 2002 Nov;283(5):H1819-28.


Modulation by peroxynitrite of Akt- and AMP-activated kinase-dependent Ser1179 phosphorylation of endothelial nitric oxide synthase.

Zou MH, Hou XY, Shi CM, Nagata D, Walsh K, Cohen RA.

J Biol Chem. 2002 Sep 6;277(36):32552-7. Epub 2002 Jul 9.


Reciprocal phosphorylation and regulation of endothelial nitric-oxide synthase in response to bradykinin stimulation.

Harris MB, Ju H, Venema VJ, Liang H, Zou R, Michell BJ, Chen ZP, Kemp BE, Venema RC.

J Biol Chem. 2001 May 11;276(19):16587-91. Epub 2001 Feb 28.


TNF-alpha inhibits flow and insulin signaling leading to NO production in aortic endothelial cells.

Kim F, Gallis B, Corson MA.

Am J Physiol Cell Physiol. 2001 May;280(5):C1057-65.


Endothelial NO synthase phosphorylated at SER635 produces NO without requiring intracellular calcium increase.

Boo YC, Sorescu GP, Bauer PM, Fulton D, Kemp BE, Harrison DG, Sessa WC, Jo H.

Free Radic Biol Med. 2003 Oct 1;35(7):729-41.


Gab1, SHP2, and protein kinase A are crucial for the activation of the endothelial NO synthase by fluid shear stress.

Dixit M, Loot AE, Mohamed A, Fisslthaler B, Boulanger CM, Ceacareanu B, Hassid A, Busse R, Fleming I.

Circ Res. 2005 Dec 9;97(12):1236-44. Epub 2005 Nov 10.


Phosphorylation of Thr(495) regulates Ca(2+)/calmodulin-dependent endothelial nitric oxide synthase activity.

Fleming I, Fisslthaler B, Dimmeler S, Kemp BE, Busse R.

Circ Res. 2001 Jun 8;88(11):E68-75.


Vanadate is a potent activator of endothelial nitric-oxide synthase: evidence for the role of the serine/threonine kinase Akt and the 90-kDa heat shock protein.

Papapetropoulos A, Fulton D, Lin MI, Fontana J, McCabe TJ, Zoellner S, García-Cardeña G, Zhou Z, Gratton JP, Sessa WC.

Mol Pharmacol. 2004 Feb;65(2):407-15.


Adiponectin stimulates production of nitric oxide in vascular endothelial cells.

Chen H, Montagnani M, Funahashi T, Shimomura I, Quon MJ.

J Biol Chem. 2003 Nov 7;278(45):45021-6. Epub 2003 Aug 27.

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