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Results: 1 to 20 of 133

1.

Benzylidene analogs of anabaseine display partial agonist and antagonist properties at the mouse 5-hydroxytryptamine(3A) receptor.

Machu TK, Hamilton ME, Frye TF, Shanklin CL, Harris MC, Sun H, Tenner TE Jr, Soti FS, Kem WR.

J Pharmacol Exp Ther. 2001 Dec;299(3):1112-9.

PMID:
11714901
[PubMed - indexed for MEDLINE]
Free Article
2.

N-terminal domains in mouse and human 5-hydroxytryptamine3A receptors confer partial agonist and antagonist properties to benzylidene analogs of anabaseine.

Zhang R, White NA, Soti FS, Kem WR, Machu TK.

J Pharmacol Exp Ther. 2006 Jun;317(3):1276-84. Epub 2006 Mar 21.

PMID:
16551836
[PubMed - indexed for MEDLINE]
Free Article
3.

Hydroxy metabolites of the Alzheimer's drug candidate 3-[(2,4-dimethoxy)benzylidene]-anabaseine dihydrochloride (GTS-21): their molecular properties, interactions with brain nicotinic receptors, and brain penetration.

Kem WR, Mahnir VM, Prokai L, Papke RL, Cao X, LeFrancois S, Wildeboer K, Prokai-Tatrai K, Porter-Papke J, Soti F.

Mol Pharmacol. 2004 Jan;65(1):56-67.

PMID:
14722237
[PubMed - indexed for MEDLINE]
Free Article
4.

Analysis of 3-(4-hydroxy, 2-Methoxybenzylidene)anabaseine selectivity and activity at human and rat alpha-7 nicotinic receptors.

Meyer EM, Kuryatov A, Gerzanich V, Lindstrom J, Papke RL.

J Pharmacol Exp Ther. 1998 Dec;287(3):918-25.

PMID:
9864273
[PubMed - indexed for MEDLINE]
Free Article
5.

Nicotinic agonists competitively antagonize serotonin at mouse 5-HT3 receptors expressed in Xenopus oocytes.

Gurley DA, Lanthorn TH.

Neurosci Lett. 1998 May 15;247(2-3):107-10.

PMID:
9655604
[PubMed - indexed for MEDLINE]
6.

Interaction of benzylidene-anabaseine analogues with agonist and allosteric sites on muscle nicotinic acetylcholine receptors.

Arias HR, Xing H, Macdougall K, Blanton MP, Soti F, Kem WR.

Br J Pharmacol. 2009 May;157(2):320-30. doi: 10.1111/j.1476-5381.2009.00156.x. Epub 2009 Mar 26.

PMID:
19338581
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Effects at a distance in alpha 7 nAChR selective agonists: benzylidene substitutions that regulate potency and efficacy.

Papke RL, Meyer EM, Lavieri S, Bollampally SR, Papke TA, Horenstein NA, Itoh Y, Porter Papke JK.

Neuropharmacology. 2004 Jun;46(7):1023-38.

PMID:
15081799
[PubMed - indexed for MEDLINE]
8.

Nicotinic agonist modulation of neurotransmitter levels in the rat frontoparietal cortex.

Summers KL, Kem WR, Giacobini E.

Jpn J Pharmacol. 1997 Jun;74(2):139-46.

PMID:
9243321
[PubMed - indexed for MEDLINE]
Free Article
9.

alpha7 receptor-selective agonists and modes of alpha7 receptor activation.

Papke RL, Meyer E, Nutter T, Uteshev VV.

Eur J Pharmacol. 2000 Mar 30;393(1-3):179-95.

PMID:
10771012
[PubMed - indexed for MEDLINE]
10.

The structural basis for GTS-21 selectivity between human and rat nicotinic alpha7 receptors.

Stokes C, Papke JK, Horenstein NA, Kem WR, McCormack TJ, Papke RL.

Mol Pharmacol. 2004 Jul;66(1):14-24.

PMID:
15213292
[PubMed - indexed for MEDLINE]
Free Article
11.

Reversal of agonist selectivity by mutations of conserved amino acids in the binding site of nicotinic acetylcholine receptors.

Horenstein NA, McCormack TJ, Stokes C, Ren K, Papke RL.

J Biol Chem. 2007 Feb 23;282(8):5899-909. Epub 2006 Dec 21.

PMID:
17189260
[PubMed - indexed for MEDLINE]
Free Article
12.

Anabaseine is a potent agonist on muscle and neuronal alpha-bungarotoxin-sensitive nicotinic receptors.

Kem WR, Mahnir VM, Papke RL, Lingle CJ.

J Pharmacol Exp Ther. 1997 Dec;283(3):979-92.

PMID:
9399967
[PubMed - indexed for MEDLINE]
Free Article
13.

Direct activation by dopamine of recombinant human 5-HT1A receptors: comparison with human 5-HT2C and 5-HT3 receptors.

Oz M, Zhang L, Rotondo A, Sun H, Morales M.

Synapse. 2003 Dec 15;50(4):303-13.

PMID:
14556235
[PubMed - indexed for MEDLINE]
14.
15.

Bicuculline antagonizes 5-HT(3A) and alpha2 glycine receptors expressed in Xenopus oocytes.

Sun H, Machu TK.

Eur J Pharmacol. 2000 Mar 17;391(3):243-9.

PMID:
10729364
[PubMed - indexed for MEDLINE]
16.

Antiemetics of the 5-hydroxytryptamine 3A antagonist class inhibit muscle nicotinic acetylcholine receptors.

Paul M, Callahan R, Au J, Kindler CH, Yost CS.

Anesth Analg. 2005 Sep;101(3):715-21, table of contents.

PMID:
16115980
[PubMed - indexed for MEDLINE]
17.
18.

Alzheimer's drug design based upon an invertebrate toxin (anabaseine) which is a potent nicotinic receptor agonist.

Kem WR.

Invert Neurosci. 1997 Sep-Dec;3(2-3):251-9. Review.

PMID:
9783447
[PubMed - indexed for MEDLINE]
20.

Pharmacological characterization of a rat 5-hydroxytryptamine type3 receptor subunit (r5-HT3A(b)) expressed in Xenopus laevis oocytes.

Mair ID, Lambert JJ, Yang J, Dempster J, Peters JA.

Br J Pharmacol. 1998 Aug;124(8):1667-74.

PMID:
9756382
[PubMed - indexed for MEDLINE]
Free PMC Article

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