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Similar articles for PubMed (Select 11691834)


Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN.

Stroschein SL, Bonni S, Wrana JL, Luo K.

Genes Dev. 2001 Nov 1;15(21):2822-36.


Two short segments of Smad3 are important for specific interaction of Smad3 with c-Ski and SnoN.

Mizuide M, Hara T, Furuya T, Takeda M, Kusanagi K, Inada Y, Mori M, Imamura T, Miyazawa K, Miyazono K.

J Biol Chem. 2003 Jan 3;278(1):531-6. Epub 2002 Nov 7.


Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein.

Stroschein SL, Wang W, Zhou S, Zhou Q, Luo K.

Science. 1999 Oct 22;286(5440):771-4.


The transforming activity of Ski and SnoN is dependent on their ability to repress the activity of Smad proteins.

He J, Tegen SB, Krawitz AR, Martin GS, Luo K.

J Biol Chem. 2003 Aug 15;278(33):30540-7. Epub 2003 May 22.


Cytoplasmic SnoN in normal tissues and nonmalignant cells antagonizes TGF-beta signaling by sequestration of the Smad proteins.

Krakowski AR, Laboureau J, Mauviel A, Bissell MJ, Luo K.

Proc Natl Acad Sci U S A. 2005 Aug 30;102(35):12437-42. Epub 2005 Aug 18.


Direct interaction between Smad3, APC10, CDH1 and HEF1 in proteasomal degradation of HEF1.

Nourry C, Maksumova L, Pang M, Liu X, Wang T.

BMC Cell Biol. 2004 May 16;5:20.


Bone morphogenetic protein-7 inhibits proximal tubular epithelial cell Smad3 signaling via increased SnoN expression.

Luo DD, Phillips A, Fraser D.

Am J Pathol. 2010 Mar;176(3):1139-47. doi: 10.2353/ajpath.2010.090459. Epub 2010 Jan 21.


SnoN and Ski protooncoproteins are rapidly degraded in response to transforming growth factor beta signaling.

Sun Y, Liu X, Ng-Eaton E, Lodish HF, Weinberg RA.

Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12442-7.


TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation.

Bonni S, Wang HR, Causing CG, Kavsak P, Stroschein SL, Luo K, Wrana JL.

Nat Cell Biol. 2001 Jun;3(6):587-95.


Downregulation of SnoN expression in obstructive nephropathy is mediated by an enhanced ubiquitin-dependent degradation.

Tan R, Zhang J, Tan X, Zhang X, Yang J, Liu Y.

J Am Soc Nephrol. 2006 Oct;17(10):2781-91. Epub 2006 Sep 7.


Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation.

Levy L, Howell M, Das D, Harkin S, Episkopou V, Hill CS.

Mol Cell Biol. 2007 Sep;27(17):6068-83. Epub 2007 Jun 25.


Sp1 and Smad proteins cooperate to mediate transforming growth factor-beta 1-induced alpha 2(I) collagen expression in human glomerular mesangial cells.

Poncelet AC, Schnaper HW.

J Biol Chem. 2001 Mar 9;276(10):6983-92. Epub 2000 Dec 12. Erratum in: J Biol Chem 2001 Dec 14;276(50):47746.


Differential ubiquitination defines the functional status of the tumor suppressor Smad4.

Morén A, Hellman U, Inada Y, Imamura T, Heldin CH, Moustakas A.

J Biol Chem. 2003 Aug 29;278(35):33571-82. Epub 2003 Jun 5.


The transcriptional co-activator P/CAF potentiates TGF-beta/Smad signaling.

Itoh S, Ericsson J, Nishikawa J, Heldin CH, ten Dijke P.

Nucleic Acids Res. 2000 Nov 1;28(21):4291-8.


Up-regulated transcriptional repressors SnoN and Ski bind Smad proteins to antagonize transforming growth factor-beta signals during liver regeneration.

Macias-Silva M, Li W, Leu JI, Crissey MA, Taub R.

J Biol Chem. 2002 Aug 9;277(32):28483-90. Epub 2002 May 21.


CHIP controls the sensitivity of transforming growth factor-beta signaling by modulating the basal level of Smad3 through ubiquitin-mediated degradation.

Xin H, Xu X, Li L, Ning H, Rong Y, Shang Y, Wang Y, Fu XY, Chang Z.

J Biol Chem. 2005 May 27;280(21):20842-50. Epub 2005 Mar 21.

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