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Results: 1 to 20 of 270

1.

Contrasting effects of IG20 and its splice isoforms, MADD and DENN-SV, on tumor necrosis factor alpha-induced apoptosis and activation of caspase-8 and -3.

Al-Zoubi AM, Efimova EV, Kaithamana S, Martinez O, El-Idrissi Mel-A, Dogan RE, Prabhakar BS.

J Biol Chem. 2001 Dec 14;276(50):47202-11. Epub 2001 Sep 27.

PMID:
11577081
[PubMed - indexed for MEDLINE]
Free Article
2.

IG20, in contrast to DENN-SV, (MADD splice variants) suppresses tumor cell survival, and enhances their susceptibility to apoptosis and cancer drugs.

Efimova EV, Al-Zoubi AM, Martinez O, Kaithamana S, Lu S, Arima T, Prabhakar BS.

Oncogene. 2004 Feb 5;23(5):1076-87.

PMID:
14716293
[PubMed - indexed for MEDLINE]
3.

IG20, a MADD splice variant, increases cell susceptibility to gamma-irradiation and induces soluble mediators that suppress tumor cell growth.

Efimova E, Martinez O, Lokshin A, Arima T, Prabhakar BS.

Cancer Res. 2003 Dec 15;63(24):8768-76.

PMID:
14695193
[PubMed - indexed for MEDLINE]
Free Article
4.

MADD/DENN splice variant of the IG20 gene is necessary and sufficient for cancer cell survival.

Mulherkar N, Ramaswamy M, Mordi DC, Prabhakar BS.

Oncogene. 2006 Oct 12;25(47):6252-61. Epub 2006 May 8.

PMID:
16682944
[PubMed - indexed for MEDLINE]
5.

MADD/DENN splice variant of the IG20 gene is a negative regulator of caspase-8 activation. Knockdown enhances TRAIL-induced apoptosis of cancer cells.

Mulherkar N, Prasad KV, Prabhakar BS.

J Biol Chem. 2007 Apr 20;282(16):11715-21. Epub 2007 Feb 21.

PMID:
17314102
[PubMed - indexed for MEDLINE]
Free Article
6.

IG20 (MADD splice variant-5), a proapoptotic protein, interacts with DR4/DR5 and enhances TRAIL-induced apoptosis by increasing recruitment of FADD and caspase-8 to the DISC.

Ramaswamy M, Efimova EV, Martinez O, Mulherkar NU, Singh SP, Prabhakar BS.

Oncogene. 2004 Aug 12;23(36):6083-94.

PMID:
15208670
[PubMed - indexed for MEDLINE]
7.

Regulation of apoptosis and caspase-8 expression in neuroblastoma cells by isoforms of the IG20 gene.

Li LC, Sheng JR, Mulherkar N, Prabhakar BS, Meriggioli MN.

Cancer Res. 2008 Sep 15;68(18):7352-61. doi: 10.1158/0008-5472.CAN-07-6311.

PMID:
18794122
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Tumour necrosis factor-induced activation of c-Jun N-terminal kinase is sensitive to caspase-dependent modulation while activation of mitogen-activated protein kinase (MAPK) or p38 MAPK is not.

Mohamed AA, Jupp OJ, Anderson HM, Littlejohn AF, Vandenabeele P, MacEwan DJ.

Biochem J. 2002 Aug 15;366(Pt 1):145-55.

PMID:
11996667
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

MADD, a splice variant of IG20, is indispensable for MAPK activation and protection against apoptosis upon tumor necrosis factor-alpha treatment.

Kurada BR, Li LC, Mulherkar N, Subramanian M, Prasad KV, Prabhakar BS.

J Biol Chem. 2009 May 15;284(20):13533-41. doi: 10.1074/jbc.M808554200. Epub 2009 Mar 16.

PMID:
19289468
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Fas-associated death domain protein and caspase-8 are not recruited to the tumor necrosis factor receptor 1 signaling complex during tumor necrosis factor-induced apoptosis.

Harper N, Hughes M, MacFarlane M, Cohen GM.

J Biol Chem. 2003 Jul 11;278(28):25534-41. Epub 2003 Apr 29.

PMID:
12721308
[PubMed - indexed for MEDLINE]
Free Article
12.

The novel triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO) potently enhances apoptosis induced by tumor necrosis factor in human leukemia cells.

Stadheim TA, Suh N, Ganju N, Sporn MB, Eastman A.

J Biol Chem. 2002 May 10;277(19):16448-55. Epub 2002 Mar 5.

PMID:
11880365
[PubMed - indexed for MEDLINE]
Free Article
13.

Ultraviolet-irradiation-induced apoptosis is mediated via ligand independent activation of tumor necrosis factor receptor 1.

Sheikh MS, Antinore MJ, Huang Y, Fornace AJ Jr.

Oncogene. 1998 Nov 19;17(20):2555-63.

PMID:
9840918
[PubMed - indexed for MEDLINE]
Free Article
14.

Protein kinase C modulates tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by targeting the apical events of death receptor signaling.

Harper N, Hughes MA, Farrow SN, Cohen GM, MacFarlane M.

J Biol Chem. 2003 Nov 7;278(45):44338-47. Epub 2003 Aug 14.

PMID:
12920112
[PubMed - indexed for MEDLINE]
Free Article
15.

Transcription factor AP-2alpha is preferentially cleaved by caspase 6 and degraded by proteasome during tumor necrosis factor alpha-induced apoptosis in breast cancer cells.

Nyormoi O, Wang Z, Doan D, Ruiz M, McConkey D, Bar-Eli M.

Mol Cell Biol. 2001 Aug;21(15):4856-67.

PMID:
11438643
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis.

Razmara M, Srinivasula SM, Wang L, Poyet JL, Geddes BJ, DiStefano PS, Bertin J, Alnemri ES.

J Biol Chem. 2002 Apr 19;277(16):13952-8. Epub 2002 Jan 30.

PMID:
11821383
[PubMed - indexed for MEDLINE]
Free Article
17.

Interferon-gamma differentially regulates monocyte matrix metalloproteinase-1 and -9 through tumor necrosis factor-alpha and caspase 8.

Zhou M, Zhang Y, Ardans JA, Wahl LM.

J Biol Chem. 2003 Nov 14;278(46):45406-13. Epub 2003 Sep 5.

PMID:
12960156
[PubMed - indexed for MEDLINE]
Free Article
20.

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