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Items: 1 to 20 of 178


Crystal structure of the dimeric extracellular domain of human carbonic anhydrase XII, a bitopic membrane protein overexpressed in certain cancer tumor cells.

Whittington DA, Waheed A, Ulmasov B, Shah GN, Grubb JH, Sly WS, Christianson DW.

Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9545-50. Epub 2001 Aug 7.


Expression, assay, and structure of the extracellular domain of murine carbonic anhydrase XIV: implications for selective inhibition of membrane-associated isozymes.

Whittington DA, Grubb JH, Waheed A, Shah GN, Sly WS, Christianson DW.

J Biol Chem. 2004 Feb 20;279(8):7223-8. Epub 2003 Dec 3.


Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX.

Alterio V, Hilvo M, Di Fiore A, Supuran CT, Pan P, Parkkila S, Scaloni A, Pastorek J, Pastorekova S, Pedone C, Scozzafava A, Monti SM, De Simone G.

Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16233-8. doi: 10.1073/pnas.0908301106. Epub 2009 Sep 14.


Crystal structure of the secretory form of membrane-associated human carbonic anhydrase IV at 2.8-A resolution.

Stams T, Nair SK, Okuyama T, Waheed A, Sly WS, Christianson DW.

Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):13589-94.


Carbonic anhydrase IX: Biochemical and crystallographic characterization of a novel antitumor target.

De Simone G, Supuran CT.

Biochim Biophys Acta. 2010 Feb;1804(2):404-9. doi: 10.1016/j.bbapap.2009.07.027. Epub 2009 Aug 11. Review.


Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties.

Genis C, Sippel KH, Case N, Cao W, Avvaru BS, Tartaglia LJ, Govindasamy L, Tu C, Agbandje-McKenna M, Silverman DN, Rosser CJ, McKenna R.

Biochemistry. 2009 Feb 17;48(6):1322-31. doi: 10.1021/bi802035f.


Structure determination of murine mitochondrial carbonic anhydrase V at 2.45-A resolution: implications for catalytic proton transfer and inhibitor design.

Boriack-Sjodin PA, Heck RW, Laipis PJ, Silverman DN, Christianson DW.

Proc Natl Acad Sci U S A. 1995 Nov 21;92(24):10949-53.


Crystal structure of carbonic anhydrase from Neisseria gonorrhoeae and its complex with the inhibitor acetazolamide.

Huang S, Xue Y, Sauer-Eriksson E, Chirica L, Lindskog S, Jonsson BH.

J Mol Biol. 1998;283(1):301-10.


Structural studies of β-carbonic anhydrase from the green alga Coccomyxa: inhibitor complexes with anions and acetazolamide.

Huang S, Hainzl T, Grundström C, Forsman C, Samuelsson G, Sauer-Eriksson AE.

PLoS One. 2011;6(12):e28458. doi: 10.1371/journal.pone.0028458. Epub 2011 Dec 5.


Human carbonic anhydrase XII: cDNA cloning, expression, and chromosomal localization of a carbonic anhydrase gene that is overexpressed in some renal cell cancers.

Türeci O, Sahin U, Vollmar E, Siemer S, Göttert E, Seitz G, Parkkila AK, Shah GN, Grubb JH, Pfreundschuh M, Sly WS.

Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7608-13.


Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide.

Di Fiore A, Monti SM, Hilvo M, Parkkila S, Romano V, Scaloni A, Pedone C, Scozzafava A, Supuran CT, De Simone G.

Proteins. 2009 Jan;74(1):164-75. doi: 10.1002/prot.22144.


Drug design studies of the novel antitumor targets carbonic anhydrase IX and XII.

Guler OO, De Simone G, Supuran CT.

Curr Med Chem. 2010;17(15):1516-26. Review.


Carbonic anhydrase inhibitors: X-ray and molecular modeling study for the interaction of a fluorescent antitumor sulfonamide with isozyme II and IX.

Alterio V, Vitale RM, Monti SM, Pedone C, Scozzafava A, Cecchi A, De Simone G, Supuran CT.

J Am Chem Soc. 2006 Jun 28;128(25):8329-35.


Structural basis of the oxidative activation of the carboxysomal gamma-carbonic anhydrase, CcmM.

Peña KL, Castel SE, de Araujo C, Espie GS, Kimber MS.

Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2455-60. doi: 10.1073/pnas.0910866107. Epub 2010 Jan 25.


Cloning and characterization of MN, a human tumor-associated protein with a domain homologous to carbonic anhydrase and a putative helix-loop-helix DNA binding segment.

Pastorek J, Pastoreková S, Callebaut I, Mornon JP, Zelník V, Opavský R, Zat'ovicová M, Liao S, Portetelle D, Stanbridge EJ, et al.

Oncogene. 1994 Oct;9(10):2877-88.


Structures of murine carbonic anhydrase IV and human carbonic anhydrase II complexed with brinzolamide: molecular basis of isozyme-drug discrimination.

Stams T, Chen Y, Boriack-Sjodin PA, Hurt JD, Liao J, May JA, Dean T, Laipis P, Silverman DN, Christianson DW.

Protein Sci. 1998 Mar;7(3):556-63.


Purification and kinetic analysis of recombinant CA XII, a membrane carbonic anhydrase overexpressed in certain cancers.

Ulmasov B, Waheed A, Shah GN, Grubb JH, Sly WS, Tu C, Silverman DN.

Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14212-7.


Reconstitution of carbonic anhydrase activity of the cell-surface-binding protein of vaccinia virus.

Ohradanova A, Vullo D, Kopacek J, Temperini C, Betakova T, Pastorekova S, Pastorek J, Supuran CT.

Biochem J. 2007 Oct 1;407(1):61-7.

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